Effect of Anaesthesia on ER Stress in Cancer Patients

Sponsor

Konkuk University Medical Center (Other)

Overall Status

Completed

CT.gov ID

NCT03561831

Collaborator

(none)

Enrollment

Location

Arms

11.8

Actual Duration (Months)

4.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Condition or Disease	Intervention/Treatment	Phase
Endoplasmic Reticulum Stress	Drug: Propofol Drug: Sevoflurane	N/A

Detailed Description

We hypothesize propofol and sevoflurane based anesthesia would show different pattern of endoplasmic reticulum stress after cancer surgery in patients with cancer

Study Design

Study Type:

Interventional

Actual Enrollment :

53 participants

Allocation:

Randomized

Intervention Model:

Factorial Assignment

Masking:

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Basic Science

Official Title:

Evaluation the Effects of Anaesthetic Agents on Endoplasmic Reticulum Stress During Cancer Surgery

Actual Study Start Date :

Jun 5, 2018

Actual Primary Completion Date :

May 29, 2019

Actual Study Completion Date :

May 29, 2019

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: propofol group patients who anesthesized by propofol	Drug: Propofol propofol based anesthesia
Active Comparator: sevoflurane group patients who anesthesized by sevoflurane	Drug: Sevoflurane sevoflurane based anesthesia

Arm

Intervention/Treatment

Active Comparator: propofol group

patients who anesthesized by propofol

Drug: Propofol

propofol based anesthesia

Active Comparator: sevoflurane group

patients who anesthesized by sevoflurane

Drug: Sevoflurane

sevoflurane based anesthesia

Outcome Measures

Primary Outcome Measures

Change in endoplasmic reticulum stress [baseline, postoperative 1 hours and 24 hours]
Change in endoplasmic reticulum stress

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years and Older

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Inclusion Criteria:

patients with cancer

Exclusion Criteria:

age under 19 years old
allergy history to propofol or sevoflurane
history of previous cancer

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Konkuk University Medical Center	Seoul		Korea, Republic of	05030

Sponsors and Collaborators

Konkuk University Medical Center

Investigators

Principal Investigator: Seong-Hyop Kim, Professor, Konkuk University Medical Center

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Seong-Hyop Kim, Professor, Konkuk University Medical Center

ClinicalTrials.gov Identifier:

NCT03561831

Other Study ID Numbers:

KUH1160108

First Posted:

Jun 19, 2018

Last Update Posted:

Oct 15, 2021

Last Verified:

Oct 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Propofol

Sevoflurane

Study Results

No Results Posted as of Oct 15, 2021