The Endothelial Count in Pxf

Sponsor

Assiut University (Other)

Overall Status

Unknown status

CT.gov ID

NCT03265457

Collaborator

(none)

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.

Condition or Disease	Intervention/Treatment	Phase
Pseudoexfoliation Syndrome	Other: Specular microscopy

Detailed Description

The corneal Endothelium is essential for the maintenance of normal corneal hydration, thickness, and transparency.

In patients with pseudoexfoliation syndrome , quantitative and qualitative morphological changes of the corneal endothelium have been demonstrated in specular and electron microscopic studies.

Specular microscopy is a non-invasive technique to access the structure and function of the corneal endothelium.

Our research question is to study Endothelial cell count in patients with pseudoexfoliation syndrome & compare it to age matched group.

Study Design

Study Type:

Observational

Anticipated Enrollment :

20 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

The Corneal Endothelial Cell Count in Eyes With Pseudoexfoliation Syndrome

Anticipated Study Start Date :

Oct 1, 2018

Anticipated Primary Completion Date :

Oct 1, 2019

Anticipated Study Completion Date :

Oct 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
patient with pseudoexfoliation syndrome The corneal Endothelial cell count will be measured by specular microscopy	Other: Specular microscopy Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group
Normal people at same age	Other: Specular microscopy Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Arm

Intervention/Treatment

patient with pseudoexfoliation syndrome

The corneal Endothelial cell count will be measured by specular microscopy

Other: Specular microscopy

Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Normal people at same age

Other: Specular microscopy

Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Outcome Measures

Primary Outcome Measures

Comparison between endothelial cell count in patients with Pseudoexfoliation syndrome and age matched controls. [One year]
The corneal Endothelial cell count in patients with pseudoexfoliation syndrome will be measured by the specular microscopy & compared with the normal endothelial count in people at the same group

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Patients with pseudoexfoliation syndrome

Exclusion Criteria:

Patients with previous intra ocular surgeries.
Patients with uveitis
Patients with fuck's endothelial dystrophy

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Assiut University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

Miyake K, Matsuda M, Inaba M. Corneal endothelial changes in pseudoexfoliation syndrome. Am J Ophthalmol. 1989 Jul 15;108(1):49-52.

Responsible Party:

Amira Asem, Principal investigator, Assiut University

ClinicalTrials.gov Identifier:

NCT03265457

Other Study ID Numbers:

First Posted:

Aug 29, 2017

Last Update Posted:

Jun 26, 2018

Last Verified:

Jun 1, 2018

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Exfoliation Syndrome

Syndrome

Study Results

No Results Posted as of Jun 26, 2018