Effects of Breaking Sitting on Human Behaviour and Metabolic Health

Sponsor

National Taiwan Normal University (Other)

Overall Status

Completed

CT.gov ID

NCT05911490

Collaborator

Division of Endocrinology and Metabolism, Tri-Service General Hospital (Other)

Enrollment

Location

Arms

9.3

Actual Duration (Months)

2.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study primarily aimed to investigate effects of breaking up prolonged sitting with intermittent brisk walking in healthy young individuals on (1) post-trial human behaviours including energy intake and physical activity under free-living conditions and (2) cognitive performance in a simulated workplace environment.

Condition or Disease	Intervention/Treatment	Phase
Energy Balance Physical Activity Level Cognition Metabolic Health	Behavioral: Prolonged sitting Behavioral: Breaking prolonged sitting	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

24 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Effects of Breaking Prolonged Sitting on 24-h Human Behaviours, Self-feelings, Metabolic Health and Cognition in Healthy Adults

Actual Study Start Date :

Dec 20, 2019

Actual Primary Completion Date :

Sep 29, 2020

Actual Study Completion Date :

Sep 29, 2020

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Prolonged sitting Participants sat on a chair during the trial in the laboratory.	Behavioral: Prolonged sitting In the laboratory, after consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.
Experimental: Breaking prolonged sitting Participants walked regularly during the trial in the laboratory.	Behavioral: Breaking prolonged sitting In the laboratory, after consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

Arm

Intervention/Treatment

Active Comparator: Prolonged sitting

Participants sat on a chair during the trial in the laboratory.

Behavioral: Prolonged sitting

In the laboratory, after consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

Experimental: Breaking prolonged sitting

Participants walked regularly during the trial in the laboratory.

Behavioral: Breaking prolonged sitting

In the laboratory, after consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

Outcome Measures

Primary Outcome Measures

Physical activity level [480 minutes]
Changes in physical activity level (steps) in the free-living conditions
Energy intake [480 minutes]
Changes in energy intake (kcal) in the free-living conditions
Cognitive performance [320 minutes]
Changes in cognitive performance (% changes in accuracy) including Task Switching and Flanker tasks
Cognitive function [320 minutes]
Changes in cognitive performance (% changes in reaction time) Task Switching and Flanker tasks

Secondary Outcome Measures

Postprandial glucose concentrations [320 minutes]
Changes in postprandial finger pricking glucose concentrations
Blood pressure [320 minutes]
Changes in systolic blood pressure and diastolic blood pressure
Visual analogue scale (VAS) [320 minutes]
Changes in self-perceived sensations including appetite, energy and mood (score from 0-100)
Continuous glucose monitoring [320 minutes]
Changes in different depots of adipose tissue interstitial glucose concentrations

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 45 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Without current and any history of brain injury, neurological disorder, cardiometabolic related diseases, diabetes or cancers.
Weight stable (not self-reported weight change ± 3 kg at least 3 months)
Body mass index (BMI) ranging between 18.5 to 27 kg/m2
Can walk safely on a treadmill

Exclusion Criteria:

Smokers, post-menopausal female, and volunteers who used any medications that could influence metabolic and inflammatory responses.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	National Taiwan Normal University	Taipei		Taiwan

Sponsors and Collaborators

National Taiwan Normal University
Division of Endocrinology and Metabolism, Tri-Service General Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Yung-Chih Chen, Principal Investigator, National Taiwan Normal University

ClinicalTrials.gov Identifier:

NCT05911490

Other Study ID Numbers:

2-108-05-151

First Posted:

Jun 22, 2023

Last Update Posted:

Jun 22, 2023

Last Verified:

Jun 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Yung-Chih Chen, Principal Investigator, National Taiwan Normal University

Breaking up sitting

Eating behaviour

Spontaneous physical activity

Executive function

Energy balance

Study Results

No Results Posted as of Jun 22, 2023