The Acute Effect of Vaping on Food Intake
Study Details
Study Description
Brief Summary
This study assesses the acute effects of a standardized 20-minute vaping episode compared to a non-vaping control condition on ad libitum food intake during a 30-minute buffet meal, occurring approximately 45 minutes after the vaping episode
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Weight control is a common motive for cigarette smoking and nicotine has been shown to suppress appetite and increase resting metabolic rate, and also serves as a behavioral alternative to eating or a distraction from hunger or food craving. Data on the acute effect of e-cigarette use ('vaping') on ad libitum food intake are non-existent. Given that many e-cigarette users report vaping for weight control and that certain e-cigarettes are being actively marketed for weight management and/or suppression of food cravings, addressing this research gap is of the utmost importance.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Vaping to Control Group Participants in this arm will undergo the vaping condition during the first visit and the control condition during the second visit. |
Other: Vaping condition
Participants will be asked to use a JUUL device to vape 20 puffs over 20 minutes. Participants will use JUUL pods with ~5% nicotine by weight. The anticipated amount of nicotine that will be absorbed with 20 puffs is approximately 1.6 mg, which is equal to approximately 1.5 cigarettes.
Other: Control condition
Participants will have access to an uncharged JUUL device with an empty pod for 20 minutes.
|
| Experimental: Control to Vaping Group Participants in this arm will undergo the control condition during the first visit and the vaping condition during the second visit. |
Other: Vaping condition
Participants will be asked to use a JUUL device to vape 20 puffs over 20 minutes. Participants will use JUUL pods with ~5% nicotine by weight. The anticipated amount of nicotine that will be absorbed with 20 puffs is approximately 1.6 mg, which is equal to approximately 1.5 cigarettes.
Other: Control condition
Participants will have access to an uncharged JUUL device with an empty pod for 20 minutes.
|
Outcome Measures
Primary Outcome Measures
- Energy Intake [30 minutes]
Energy intake in kilocalories (kcal) during the ad libitum buffet meal will be measured via directly weighed food provision and waste (food/energy intake is calculated by difference).
Secondary Outcome Measures
- Dietary Fat Intake [30 minutes]
Dietary fat intake in kilocalories (kcal) during the ad libitum buffet meal will be measured via directly weighed dietary fat provision and waste (dietary fat intake is calculated by difference).
- Carbohydrate Intake [30 minutes]
Carbohydrate intake in kilocalories (kcal) during the ad libitum buffet meal will be measured via directly weighed carbohydrate provision and waste (carbohydrate intake is calculated by difference).
- Protein Intake [30 minutes]
Protein intake in kilocalories (kcal) during the ad libitum buffet meal will be measured via directly weighed protein provision and waste (protein intake is calculated by difference).
- Difference in Food Cravings [Visit 1 to visit 2 (1 week)]
Total score in the Food Cravings Questionnaire State after the vaping vs after the non-vaping condition. Fifteen items are rated on a 5-point Likert Scale (Strongly Disagree=1, Disagree=2, Neutral=3, Agree=4, Strongly Agree=5) with higher scores indicating higher food cravings.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
18 - 65 years of age (ID card verified)
-
Reports using an e-cigarette containing at least 3% (30 mg/ml) nicotine on a frequent basis - defined as at least 3 days per week for the past 30 days
Exclusion Criteria:
-
being unwilling to consume the foods provided due to: a) dietary limitations or preferences or b) allergies to the foods provided.
-
being unwilling to take 20 puffs from a JUUL device containing a 5% nicotine pod
-
self-reported current, diagnosed medical condition(s) will be excluded automatically: heart-related conditions (e.g., recent heart attack/stroke, coronary heart disease), severe immune system disorders (e.g., HIV/AIDS, multiple sclerosis), respiratory disorders (e.g., COPD, asthma), kidney diseases, liver diseases (e.g., cirrhosis), or seizures
-
observed high blood pressure at screening (systolic >140; diastolic >90)
-
other self-reported current, diagnosed medical conditions (e.g., specific food allergies, diabetes, thyroid disease, lyme disease) will be considered for exclusion after consultation with the PI and medical monitor
-
self-reported current, diagnosed psychiatric conditions or who report current psychiatric treatment or psychotropic medication use
-
past month use of cocaine, opioids, benzodiazepines, methamphetamine, or other (non-cannabis) illicit drugs
-
self-report of >25 days out of the past 30 for alcohol use or >20 days out of the past 30 for cannabis use.
-
women who are breast-feeding or test positive for pregnancy (by urinalysis at screening)
-
women using progestin-IUDS for birth control
-
women using birth control injections (e.g., Depo-Provera)
-
women who received a hysterectomy and still have ovaries present
-
self-report intending to quit tobacco/nicotine products in the next 30 days
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Center for the Study of Tobacco Products | Richmond | Virginia | United States | 23220 |
Sponsors and Collaborators
- Virginia Commonwealth University
- Pennington Biomedical Research Center
- National Institute on Drug Abuse (NIDA)
Investigators
- Principal Investigator: Caroline Cobb (Amey), PhD, Virginia Commonwealth University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HM20018382
- 2019-066-PBRC
- U54DA036105