Environmental Contaminants and Infant Development
Study Details
Study Description
Brief Summary
This study is designed to examine the effects of prenatal exposure to environmental contaminants on cognitive and behavioral development and physical growth in two groups of Inuit infants-one in Northern Quebec; the other in Greenland.
| Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Due to prevailing weather patterns and ocean currents, certain environmental contaminants are transported to the Arctic region. The Inuit are among the most heavily exposed populations on earth due to the prevalence of these contaminants in traditional foods that comprise a large portion of their diet. The contaminants assessed in this study include polychlorinated biphenyls (PCBs), methylmercury, selenium, organochlorine pesticides, and lead. These contaminants are measured in umbilical cord blood samples obtained at birth, milk samples obtained from breast-feeding mothers and, in the case of mercury, hair samples obtained from the mothers. Omega-3 and omega-6 fatty acids are also assessed in these samples to examine the degree to which these nutrients may protect against adverse effects attributable to these contaminants.
Study Design
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
infant born during recruitment period to a mother who is a resident of Povungnituk, Inukjuak, and Kuujjuarapik, Quebec or Nuuk, Greenland
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Public Health Centre of Quebec | Beauport | Quebec | Canada |
Sponsors and Collaborators
- National Institute of Environmental Health Sciences (NIEHS)
- Indian and Northern Affairs, Canada
- Health Canada
- Danish Institute for Public Health
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Dewailly E, Ayotte P, Bruneau S, Laliberté C, Muir DC, Norstrom RJ. Inuit exposure to organochlorines through the aquatic food chain in arctic québec. Environ Health Perspect. 1993 Dec;101(7):618-20.
- Dewailly, E., Bruneau, S., Ayotte, P., Liliberte, C., Gingras, S. Belander, D. and Ferron, L. Health status at birth of Inuit newborn prenatally exposed to organochlorines - Chemosphre, 1993, 27: 359-366.
- Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783-9.
- Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853-60.
- 7902-CP-001