Epicardial Adipose Tissue Thickness and the Related Factors in Patients With Ankylosing Spondylitis
Study Details
Study Description
Brief Summary
The aim of this study was to assess the EATT and the related factors in patients with AS and to compare the results with that of the healthy controls'
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The aim of this study was to investigate the epicardial adipose tissue thickness (EATT) and the related factors in patients with ankylosing spondylitis (AS) and to compare the results with those of the healthy controls. This cross-sectional study comprised thirty patients diagnosed with AS based on the modified New York criteria. The control group consisted of 31 healthy volunteers. Demographic characteristics were recorded. EATT was measured via transthoracic echocardiography. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Ankylosing Spondylitis Quality of Life (ASQoL), International Physical Activity Questionnaire Short Form (IPAQ-Short Form) were used. Functional capacity assessment was conducted using the six-minute walk test (6MWT).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Ankylosing spondylitis group Thirty patients with AS according to the modified New York criteria were included in this cross-sectional study. |
Diagnostic Test: epicardial adipose tissue thickness
EATT measured via transthoracic echocardiography
|
| Healthy volunteers Control group was consisted of 31 healthy volunteers |
Diagnostic Test: epicardial adipose tissue thickness
EATT measured via transthoracic echocardiography
|
Outcome Measures
Primary Outcome Measures
- Epicardial adipose tissue thickness [through study completion, an average of 5 months]
Epicardial adipose tissue thickness is measured via transthoracic echocardiography
Secondary Outcome Measures
- Bath Ankylosing Spondylitis Disease Activity Index [through study completion, an average of 5 months]
The index indicates that disease activity of AS patients. Higher scores indicate that higher activity
- Bath Ankylosing Spondylitis Functional Index [through study completion, an average of 5 months]
The index helps to evaluate disease activity of AS patients. High scores indicate that worse functional status.
- Bath Ankylosing Spondylitis Metrology Index [through study completion, an average of 5 months]
The index helps to evaluate spinal mobility of AS patients. Higher scores indicate more limited mobility.
- Ankylosing Spondylitis Disease Activity Score [through study completion, an average of 5 months]
This score is used to evaluate disease activity of AS patients. Higher scores indicate that higher activity.
- Six minute walk test [through study completion, an average of 5 months]
This test is used to evaluate the patient's functional capacity. In case of low functional capacity, lower scores are observed. Higher scores indicate that higher activity.
- Ankylosing Spondylitis Quality of Life [through study completion, an average of 5 months]
it is used for evaluate quality of life of AS patients. A lower score indicates better quality of life
- International Physical Activity Questionnaire Short Form [through study completion, an average of 5 months]
it is used for evaluate patient's physical activity. Scoring a high level of physical activity on the IPAQ means your physical activity levels equate to approximately one hour of activity per day or more at least a moderate intensity activity level.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Disease duration >1 year,
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Being ≥18 years
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AS diagnosis according to modified New York Criteria
Exclusion Criteria:
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Being illiterate,
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65 years,
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History of ischemic heart disease,
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Cerebrovascular disease,
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Hypertension,
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Chronic kidney failure,
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endocrinopathies like diabetes mellitus,
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hypothyroidism,
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Cushing syndrome and primary hyperlipidemia.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | Istanbul | Turkey |
Sponsors and Collaborators
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Investigators
- Study Chair: Nur Kesiktas, MD, Prof, Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IstPRMTRH5