Epicardial Fat, Visceral Fat and Coronary Atherosclerosis

Sponsor

Ziv Hospital (Other)

Overall Status

Unknown status

CT.gov ID

NCT01344694

Collaborator

(none)

110

Enrollment

Location

Duration (Months)

13.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Condition or Disease	Intervention/Treatment	Phase
Epicardial Fat Visceral Fat Atherosclerosis	Other: patient with liver fat Other: pts. with excess of visceral fat Other: control

Detailed Description

Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease. The independent role of epicardial fat deposition in cardiovascular risk remains unclear. Aim: Evaluate the link between epicardial fat, visceral fat, liver fat accumulation and cardiovascular diseases and carotis atherosclerosis in patients with the major cardiovascular risk factors and with or without metabolic syndrome.

Study Design

Study Type:

Observational

Anticipated Enrollment :

110 participants

Time Perspective:

Retrospective

Official Title:

Association Between Epicardial Fat, Visceral Fat Accumulation & Cardiovascular Atherosclerosis

Study Start Date :

Jul 1, 2011

Anticipated Primary Completion Date :

Feb 1, 2012

Anticipated Study Completion Date :

Mar 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
patient with liver fat 30 patients with liver fat	Other: patient with liver fat 30 patient with liver fat
excess of visceral fat 50 pts. with excess of visceral fat	Other: pts. with excess of visceral fat pts. with excess of visceral fat
control 30 control subjects	Other: control 30 control subjects

Arm

Intervention/Treatment

patient with liver fat

30 patients with liver fat

Other: patient with liver fat

30 patient with liver fat

excess of visceral fat

50 pts. with excess of visceral fat

Other: pts. with excess of visceral fat

pts. with excess of visceral fat

control

30 control subjects

Other: control

30 control subjects

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

40 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Patients referred to cardiac CT will be the source of recruitment.
patients with excess of visceral fat,
30 patients with liver fat accumulation
30 sex-age-matched individual (controls) will be enrolled. All patients will undergo a complete family history, personal clinical history, physical examination and blood sampling for biochemical analysis.
Informed consent will be obtained from each individual.

Exclusion Criteria:

subjects with severe morbid obesity (body mass index [BMI] > 40),
recent history of acute illness,
clinical history of ischemic heart disease and cerebrovascular disease,
typical chest pain,
previous coronary artery disease,
conventional coronary angiography, percutaneous interventions, coronary by pass grafting, renal failure, cancer patients,
subjects who take drugs that induces hepatic steatosis ( corticosteroids, estrogens, methotrexate, amiodarone and others)