The Epidemiology of Aortic Diameter in China

Sponsor

Zhejiang University (Other)

Overall Status

Unknown status

CT.gov ID

NCT00820378

Collaborator

Taizhou Hospital (Other)

2,000

Enrollment

Locations

Duration (Months)

1000

Patients Per Site

12.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Aortic aneurysms are the major disease processes affecting the aorta and becoming a relatively common cause of death because of rupture or dissection. The most common location for aneurysms is the infrarenal abdominal aorta, followed by the ascending thoracic aorta. Unlike coronary heart disease, the incidence of abdominal aortic aneurysm (AAA) in the United States and Europe has been increasing, and this increase may not be due to higher levels of screening for this condition alone. Aortic diameter is central to the diagnosis of aortic aneurysm. Furthermore, it was demonstrated that non-AAA patients with an enlarged diameter of the infrarenal aortic diameter are also at high risk for all-cause mortality. And aortic root dimension was associated with several coronary artery disease (CHD) risk factors and measures of subclinical disease and was predictive of incident congestive heart failure (CHF), stroke, cardiovascular disease (CVD) mortality, and all-cause mortality, but not of incident MI. Up to now, there are limited studies on the epidemiology of aortic diameter, especially in Chinese population.

Condition or Disease	Intervention/Treatment	Phase
Vascular Disease Diabetes Hypertension Hyperlipidemia	Other: No special interventioin

Detailed Description

The purpose of this study was to analyze the size of the entire aorta at different anatomic levels in a large group of Chinese population with clinically evident arterial disease or cardiovascular risk factors to further explored the risk factors and potential alternative pathomechanisms for the development of aortic dilatation. Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels: (1) the annulus, (2) the mid-point of the sinuses of Valsalva, (3) the sinotubular junction, (4) the ascending aorta at the level of its largest diameter, (5) the transverse arch, (6) the descending aorta posterior to the left atrium, and (7) the abdominal aorta just distal to the origin of the renal arteries. The extension of dilation is defined as the number of dilated aortic segments. The relations among aortic dimensions and clinical characteristics will be assessed by multiple regression analysis. The current study was to determine the association of risk factors of CVD and atherosclerosis diseases with aortic dimension in Chinese patients with clinical event atherosclerotic disease or risk factors of atherosclerotic disease.

Study Design

Study Type:

Observational

Anticipated Enrollment :

2000 participants

Observational Model:

Case-Crossover

Time Perspective:

Cross-Sectional

Official Title:

Epidemiology of Aortic Dimensions in Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors

Study Start Date :

Jan 1, 2009

Anticipated Primary Completion Date :

Dec 1, 2010

Anticipated Study Completion Date :

Dec 1, 2015

Arms and Interventions

Arm	Intervention/Treatment
atherosclerosis Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors	Other: No special interventioin Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels:

Arm

Intervention/Treatment

atherosclerosis

Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors

Other: No special interventioin

Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels:

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

40 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients aged 40 to 100 were referred to the hospital with a recent diagnosis of clinically evident arterial disease or a cardiovascular risk factor.

Exclusion Criteria:

Those with connective tissue disease, congenital heart disease, cardiomyopathy, congestive heart failure,rheumatic arthritis, secondary causes of hypertension, or active cancer.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Second Affiliated Hospital of Zhejiang University College of Medicine	Hangzhou	Zhejiang	China	317000
2	Taizhou Hospital, Wenzhou Medical College	Taizhou	Zhejiang	China	317000

Sponsors and Collaborators

Zhejiang University
Taizhou Hospital

Investigators

Study Chair: Jian-an Wang, Second Affiliated Hospital, School of Medicine, Zhejiang University
Principal Investigator: Li-jiang Tang, Taizhou Hospital, Wenzhou Medical College
Principal Investigator: Xiao-feng Chen, Second Affiliated Hospital, School of Medicine, Zhejiang University
Principal Investigator: Zhao-xia Pu, Second Affiliated Hospital, School of Medicine, Zhejiang University
Principal Investigator: Xian-fang Lin, Taizhou Hospital, Wenzhou Medical College