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Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards

Sponsor
Association Pour le Recherche en Infectiologie et en Médecine Interne (Other)
Overall Status
Completed
CT.gov ID
NCT00520715
Collaborator
Pr Bruno Fantin (Other)
640
Enrollment
1
Location
6
Duration (Months)
106.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Emergence of bacterial resistance to antibiotics, which is a major public health issue, appears to involve predominantly commensal flora. No data exists concerning risk factors for the carriage of fluoroquinolone resistant bacteria in the flora of hospitalised patients. We will conduct a prospective open study including all unselected patients hospitalised in medical wards of one hospital. Nasal, pharyngeal and rectal swabs will be performed upon admission as well as a review of potential risk factors, after patient's information and acceptance. Resistance testing aiming 3 pathogens (Staphylococcus, Streptococcus and E. coli) will be performed on all specimens, and a case control study will compare risk factors from the resistant and non-resistant groups, for each pathogen. A thousand patients should be included in a year's time. This work could help understand risk factors involved in the carriage of fluoroquinolone resistant pathogens, potentially responsible for invasive infections and inter-patient transmission of resistance. Limiting bacterial resistance and transmission is a goal that can be successfully undertaken only if resistance mechanisms, but also risk factors of acquiring resistant bacteria are better understood.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    640 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Epidemiology and Risk Factors Study of the Carriage of Fluoroquinolone Resistant Bacteria in the Commensal Flora of Patients Hospitalised in Medical Wards
    Study Start Date :
    Jun 1, 2007
    Actual Primary Completion Date :
    Nov 1, 2007
    Actual Study Completion Date :
    Dec 1, 2007

    Arms and Interventions

    Arm Intervention/Treatment
    Patients at hospital admission

    Patients at hospital admission in medical wards on our tertiray care hospital (Hôpital Beaujon, Clichy, France).

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • all adult patients admitted to the internal medicine, oncology, cardiology and geriatric unit of Beaujon Hospital, Clichy, France.

      • patient agreement

      Exclusion Criteria:

      • Age < 18

      • patient refusal or incapable

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Hôpital Beaujon Clichy Ile de France France 92110

      Sponsors and Collaborators

      • Association Pour le Recherche en Infectiologie et en Médecine Interne
      • Pr Bruno Fantin

      Investigators

      • Principal Investigator: Victoire de Lastours, MD,

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Dr Victoire de Lastours, MD, Association Pour le Recherche en Infectiologie et en Médecine Interne
      ClinicalTrials.gov Identifier:
      NCT00520715
      Other Study ID Numbers:
      • FQ/EPI
      First Posted:
      Aug 24, 2007
      Last Update Posted:
      Jun 23, 2015
      Last Verified:
      Jun 1, 2015
      Keywords provided by Dr Victoire de Lastours, MD, Association Pour le Recherche en Infectiologie et en Médecine Interne
      fluoroquinolone resistance
      commensal flora
      carriage

      Study Results

      No Results Posted as of Jun 23, 2015