Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia
Study Details
Study Description
Brief Summary
Background: Dexmedetomidine (DEX) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting analgesia of Dexmedetomidine. Methods: Select 12 patients with the proposed intraoperative MR-guided radiofrequency ablation of epilepsy. The subjects were randomized into the Dexmedetomidine group (DEX group) (n=6) and the Opioid group (OPI group) (n=6). DEX group: continuous intravenously administered 1.5 µg kg-1 h-1 dexmedetomidine 15min before anesthesia induction, continuous infusion for 15min after anesthesia induction, and then Intraoperative functional magnetic resonance imaging scanning was started. OPI group: the equivalent administered speed 0.9% sodium chloride was continuously pumped for 15min before anesthesia induction, then induce and intraoperative fMRI scanning started after continuous 30min infusion. The intraoperative fMIR scan results were compared and analyzed to find the unique analgesic brain regions of DEX, and the differences of the functional neuronal network of analgesia effect between the two groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 4 |
Detailed Description
Background: Dexmedetomidine (DEX) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting analgesia of Dexmedetomidine. Methods: Select 12 patients with the proposed intraoperative MR-guided radiofrequency ablation of epilepsy. The subjects were randomized into the Dexmedetomidine group (DEX group) (n=6) and the Opioid group (OPI group) (n=6). DEX group: continuous intravenously administered 1.5 µg kg-1 h-1 dexmedetomidine 15min before anesthesia induction, continuous infusion for 15min after anesthesia induction, and then Intraoperative functional magnetic resonance imaging scanning was started. OPI group: the equivalent administered speed 0.9% sodium chloride was continuously pumped for 15min before anesthesia induction, then induce and intraoperative fMRI scanning started after continuous 30min infusion. The intraoperative fMIR scan results were compared and analyzed to find the unique analgesic brain regions of DEX, and the differences of the functional neuronal network of analgesia effect between the two groups.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Dexmedetomidine group
|
Drug: Dexmedetomidine Injectable Solution
continuous pump of 1.5ug / kg / h Dexmedetomidine 15min before anesthesia induction, continuous infusion for 30min after anesthesia induction, and then nuclear magnetic scanning was started.
|
| Active Comparator: Opioid group
|
Drug: Sodium Chloride 0.9% Inj
the equivalent Sodium Chloride 0.9% Inj was continuously pumped before anesthesia induction, induced by opioids for 15min, and intraoperative fMRI scanning was started after continuous infusion for 30min.
|
Outcome Measures
Primary Outcome Measures
- Measurement of analgesia relative brain regions assessed by BOLD under fMRI scanning [during operation]
Measurement of analgesia relative brain regions inDexmedetomidine group (DEX group) and the Opioid group (OPI group) assessed by BOLD under fMRI scanning, and compare the two group different at the same time
Secondary Outcome Measures
- Measurement of analgesia relative brain regions assessed by T1-MPRAGE under fMRI scanning [during operation]
Measurement of analgesia relative brain regions inDexmedetomidine group (DEX group) and the Opioid group (OPI group) assessed by T1-MPRAGE under fMRI scanning, and compare the two group different at the same time
- Measurement of analgesia relative brain regions assessed by T2-SPACE under fMRI scanning [during operation]
Measurement of analgesia relative brain regions inDexmedetomidine group (DEX group) and the Opioid group (OPI group) assessed by T2-SPACE under fMRI scanning, and compare the two group different at the same time
- systolic blood pressure (SBP) [during operation]
hemodynamic change of the two groups included systolic blood pressure (SBP)
- diastolic blood pressure (DBP) [during operation]
hemodynamic change of the two groups included diastolic blood pressure (DBP)
- mean arterial pressure (MAP) [during operation]
hemodynamic change of the two groups included mean arterial pressure (MAP)
- heart rate (HR) [during operation]
hemodynamic change of the two groups included heart rate (HR)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Clinical diagnosis of epilepsy and eligible for radiofrequency ablation
-
20-50 years old;
-
American Society of Anesthesiologists rated (ASA) I-II
-
body mass index (BMI)18.5~27.9 kg·m2.
Exclusion Criteria:
-
pre-existing neuropsychiatric disorders;
-
emergency surgery;
-
coma;
-
depression;
-
cognitive impairment;
-
implanted with metal devices.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- China International Neuroscience Institution
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CINI-AD-20220706