Epileptic Seizures in Intensive Care Units

• Sponsor: University Hospital, Basel, Switzerland (Other)
• Overall Status: Completed
• CT.gov ID: NCT03860467
• Collaborator: (none)
• Enrollment: 200
• Location: 1
• Actual Duration (Months): 28.9
• Patients Per Site Per Month: 6.9

Study Details

Study Description

Brief Summary

This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to subsequently compare their characteristics with ICU-patients with status epilepticus (SE).

Condition or Disease	Intervention/Treatment	Phase
Epileptic Seizure	Other: collection of patient data

Detailed Description

The aim of this retrospective observational cohort study is to get further insight into adult patients with epileptic seizures in ICUs in an academic tertiary medical care center regarding frequency, clinical and electroencephalogram (EEG) characteristics, treatment, course and outcome. This data could help understanding the epidemiology (including risk factors, influence of EEG), and to guide management and improve outcomes of affected patients.

Study Design

• Study Type: Observational
• Actual Enrollment: 200 participants
• Observational Model: Cohort
• Time Perspective: Retrospective
• Official Title: Epileptic Seizures in Intensive Care Units
• Actual Study Start Date: Dec 1, 2019
• Actual Primary Completion Date: Apr 30, 2022
• Actual Study Completion Date: Apr 30, 2022

Outcome Measures

Primary Outcome Measures

1. Frequency of epileptic seizures [between 01.01.2005 and 19.12.2018]

   Frequency of all epileptic seizures in the ICU

Secondary Outcome Measures

1. Number of epileptic seizures captured by EEG [between 01.01.2005 and 19.12.2018]

   Number of epileptic seizures captured by EEG without overt clinical seizure presentation in the ICU

2. Number of epileptic seizures diagnosed on the basis of clinical symptoms alone [between 01.01.2005 and 19.12.2018]

   Number of epileptic seizures diagnosed on the basis of clinical symptoms alone in the ICU

3. Length of epileptic seizure (time) [between 01.01.2005 and 19.12.2018]

   Duration of epileptic seizure

4. Semiological feature of epileptic seizure (i.e. seizure types) [between 01.01.2005 and 19.12.2018]

   Semiological feature of epileptic seizure (i.e. seizure types) emerging in ICU-patients

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• admitted to the ICU at the University Hospital Basel

• suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay

Exclusion Criteria:

• patients with epileptic seizures transforming into Status epilepticus (SE)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Clinic for Intensive Care Medicine, University Hospital Basel	Basel		Switzerland	4031

Sponsors and Collaborators

• University Hospital, Basel, Switzerland

Investigators

• Principal Investigator: Raoul Sutter, PD Dr. med, Clinic for Intensive Care Medicine, University Hospital Basel

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University Hospital, Basel, Switzerland
• ClinicalTrials.gov Identifier: NCT03860467
• Other Study ID Numbers: 2018-02361; me19Sutter
• First Posted: Mar 4, 2019
• Last Update Posted: Jun 2, 2022
• Last Verified: Jun 1, 2022

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by University Hospital, Basel, Switzerland: Status epilepticus; Electroencephalogram; Intensive Care Unit
• Additional relevant MeSH terms: Seizures; Epilepsy

Study Results

No Results Posted as of Jun 2, 2022