Clincosm LogoSign in Get a demo

Multiple Respiration-Correlated Cone Beam Computed Tomography (CT) Scans to Reduce Target Positioning Errors in Radiotherapy Treatment of Thoracic Cancer

Sponsor
Memorial Sloan Kettering Cancer Center (Other)
Overall Status
Completed
CT.gov ID
NCT00722605
Collaborator
(none)
16
Enrollment
1
Location
1
Arm
54
Duration (Months)
0.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to use cone-beam CT scans to more accurately position the tumor during radiation and to see whether this method is more effective than the standard method of using 2D images (portal images), which is a type of X-ray. Cone-beam CT is a type of CT scanner attached to the treatment accelerator that produces 3D images of the patient.

The ability to eliminate the tumor with radiation depends in part on the accuracy of delivering the radiation to the lung. The position of the tumor changes because of normal breathing. Therefore, we want to improve the accuracy of the way the radiation is delivered to the tumor. With cone-beam CT scans taken before and during your treatment, we will be able to determine the location of the tumor with 3D images, measure how much the tumor moves as you breathe, and then position you so that the tumor will get the best delivery of radiation.

Condition or Disease Intervention/Treatment Phase
  • Procedure: cone-beam CT
 Phase 1/Phase 2

Study Design

Study Type:
Interventional
Actual Enrollment :
16 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Diagnostic
Official Title:
The Use of Multiple Respiration-Correlated Cone Beam CT Scans to Reduce Target Positioning Errors in Radiotherapy Treatment of Thoracic Cancer.
Study Start Date :
Jul 1, 2008
Actual Primary Completion Date :
Jan 1, 2013
Actual Study Completion Date :
Jan 1, 2013

Arms and Interventions

Arm Intervention/Treatment
Experimental: 1

cone-beam CT based

Procedure: cone-beam CT
You will have the following CT scans along with the standard weekly portal images:Before treatment you will have a CT scan (a respiratory-correlated CT scan) at the time of the radiation planning, or simulation planning.During the first week of treatment - you will have 5 cone-beam CT scans at days 1 through 5 of your radiation treatment schedule. During the remaining weeks of treatment - you will have a cone-beam CT scan every week. Depending on the number of treatments that your study doctor has prescribed for you, the number of weekly scans can be between 3 and 7. For all scans, an external monitor will be used to record your breathing. If needed, you will be repositioned by adjusting the radiation machine's treatment couch position.
Other Names:
  • The total number of cone-beam CT scans can be between 8 and 10. The scans will take about 15
  • minutes and will occur before your treatment. The scans will help determine whether the
  • radiation is being delivered accurately to the tumor and whether adjustments need to be made.

    		•

    Outcome Measures

    Primary Outcome Measures

    1. To enhance the accuracy of treatment delivery by using a cone-beam CT guided patient positioning procedure, relative to the standard portal image guided procedure. [conclusion of the study]

    Secondary Outcome Measures

    1. To determine the reduction in the proportion of patients with large target positioning errors using the cone-beam CT guided procedure. [conclusion of the study]

    2. To gather data on organ motion and setup errors in the thorax and how they vary over the treatment course, in order to develop efficient clinical correction strategies. [conclusion of the study]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patients must have histologic proof of a thoracic malignancy, confirmed at MSKCC and suitable for radiation therapy, in order to be eligible for this study.

    • Patients must be older than 18 years of age

    • At least part of the tumor must be visible as observed in a diagnostic or planning CT. Patients must have Karnofsky Performance Status ≥ 70%

    Exclusion Criteria:
    • Pregnant Women

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Memorial Sloan Kettering Cancer Center New York New York United States 10065

    Sponsors and Collaborators

    • Memorial Sloan Kettering Cancer Center

    Investigators

    • Principal Investigator: Andreas Rimner, MD, Memorial Sloan Kettering Cancer Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    Memorial Sloan Kettering Cancer Center
    ClinicalTrials.gov Identifier:
    NCT00722605
    Other Study ID Numbers:
    • 08-080
    First Posted:
    Jul 25, 2008
    Last Update Posted:
    Jan 24, 2013
    Last Verified:
    Jan 1, 2013
    Keywords provided by Memorial Sloan Kettering Cancer Center
    lung
    esophageal
    cone beam ct scan

    Study Results

    No Results Posted as of Jan 24, 2013