Clincosm LogoSign in Get a demo

Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

Sponsor
Samsung Medical Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT00516230
Collaborator
(none)
200
Enrollment
1
Location
71
Duration (Months)
2.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    200 participants
    Observational Model:
    Defined Population
    Time Perspective:
    Prospective
    Official Title:
    Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
    Study Start Date :
    Jan 1, 2006
    Anticipated Study Completion Date :
    Dec 1, 2011

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • Colorectal cancer
      Exclusion Criteria:
      • Histology showing other than adenocarcinoma

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Samsung Medical Center Seoul Gangnam-gu Korea, Republic of 135-710

      Sponsors and Collaborators

      • Samsung Medical Center

      Investigators

      • Principal Investigator: Dong Kyung Chang, M.D. Ph.D, Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00516230
      Other Study ID Numbers:
      • SMC-2007-04-080
      First Posted:
      Aug 15, 2007
      Last Update Posted:
      Aug 15, 2007
      Last Verified:
      Aug 1, 2007
      Keywords provided by , ,
      Colonic Neoplasms
      Lynch syndrome
      Additional relevant MeSH terms:
      Colonic Neoplasms

      Study Results

      No Results Posted as of Aug 15, 2007