Estimation of Dynamics of Humoral and Cellular Immunity in COVID-19 Patients
Study Details
Study Description
Brief Summary
The goal of the project: to study the dynamics of the humoral and cellular immunity in patients after pneumonia caused by the SARS-CoV-2 virus at different time intervals, in order to predict the duration of immune protection
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
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to form study groups of patients (at least 60 patients in total) who have recovered from pneumonia of varying severity caused by the SARS-CoV-2 virus (at least 30 patients in each of the groups of patients who have had pneumonia in moderate and severe forms);
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to investigate the parameters of cellular immunity (the content of antigen-specific T-cells to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia;
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to investigate the indicators of humoral immunity (the content of IgG to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| COVID-19 moderate moderate COVID-19 associated pneumonia |
Diagnostic Test: Humoral and cellular immunity
Humoral (IgG) and cellular (antigen-specific cells) immunity
|
| COVID-19 severe severe COVID-19 associated pneumonia |
Diagnostic Test: Humoral and cellular immunity
Humoral (IgG) and cellular (antigen-specific cells) immunity
|
Outcome Measures
Primary Outcome Measures
- The dynamics of humoral and cellular immunity [1 year]
The dynamics of both humoral and cellular immunity in response to COVID-19 infection
Eligibility Criteria
Criteria
Inclusion Criteria:
- patients recovered from the COVID-19 associated pneumonia (moderate and severe) in 1-3 month interval before inclusion into the trial;
Exclusion Criteria:
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cancer;
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drug and alcohol addiction;
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autoimmune diseases.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | Minsk | Belarus | 220072 |
Sponsors and Collaborators
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
- Belarusian State Medical University
- The Republican Research and Practical Center for Epidemiology and Microbiology
Investigators
- Study Director: Andrei Hancharou, MD, PHD, Director
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IBCE_COVID19_Immunity