Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery

• Sponsor: Alliance for Clinical Trials in Oncology (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT01953588
• Collaborator: National Cancer Institute (NCI) (NIH)
• Enrollment: 1,473
• Locations: 860
• Arms: 3
• Patients Per Site: 1.7

Study Details

Study Description

Brief Summary

The study is being conducted to determine whether neoadjuvant endocrine therapy with fulvestrant or the combination of anastrozole and fulvestrant, is better than anastrozole when given before surgery to shrink the cancer and stop it from growing. Anastrozole inhibits tumor growth by reducing the levels of estrogen and has been approved by the Food and Drug Administration (FDA) of the United States for use after surgery for postmenopausal women with estrogen receptor positive breast cancer. It is also considered a standard of care to give anastrozole for a few months before surgery to shrink the tumor. Fulvestrant inhibits tumor cell growth by reducing the levels of estrogen receptor in the tumor cell. It is not approved by the FDA for use in women with early stage breast cancer before or after surgery, but is approved by the FDA for patients with advanced (Stage 4) estrogen receptor positive breast cancer that has spread to other parts of the body.

Condition or Disease	Intervention/Treatment	Phase
Estrogen Receptor-positive Breast Cancer; HER2-negative Breast Cancer; Invasive Ductal Breast Carcinoma; Invasive Lobular Breast Carcinoma; Recurrent Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer	Drug: fulvestrant; Drug: anastrozole	Phase 3

Detailed Description

This clinical trial was designed to examine the pathologic outcomes of patients whose neoadjuvant treatment course is determined using an early marker of endocrine resistance (namely, Ki67 after 4 or 12 weeks of neoadjuvant therapy) as well as assessing clinical outcome of patients whose disease burden after completing neoadjuvant endocrine therapy is classified as Modified PEPI 0.

The primary and secondary objectives for the study are described below.

Primary Objectives:

1. To determine whether fulvestrant administered for 24 weeks as neoadjuvant endocrine treatment decreases the proportion of endocrine resistant tumors* relative to patients treated with anastrozole.

2. To determine whether fulvestrant in combination with anastrozole, administered for 24 weeks as neoadjuvant endocrine treatment, decreases the proportion of endocrine resistant tumors* relative to patients treated with anastrozole.

3. To assess whether the 5 year RFS rate among women with a modified preoperative endocrine prognostic index (PEPI) score of 0 following 24 weeks of neoadjuvant anastrozole treatment is at least 95%.

4. To assess whether the 5 year RFS rate among women with a modified PEPI score of 0 following 24 weeks of neoadjuvant fulvestrant, or fulvestrant in combination with anastrozole, is at least 95%. Note that this objective will only be tested if the selected fulvestrant arm was shown to be superior to anastrozole in objective 1 or 2.

Endocrine resistant tumor is defined by any one of the following criteria*:

• Ki67> 10% after 4 weeks on neoadjuvant endocrine therapy

• Ki67> 10% after 12 weeks on neoadjuvant endocrine therapy

• Progressive disease is documented anytime during neoadjuvant endocrine therapy

• Surgical findings at 22-24 weeks post neoadjuvant endocrine therapy are such that:

• pT stage is 3/4

• positive lymph nodes are present or Ki67 > 2.7% (ie modified PEPI score of not being 0)

• Discontinued neoadjuvant endocrine treatment for any reason

Secondary Objectives:

1. To assess whether the 5 year RFS rate among women with a preoperative endocrine prognostic index PEPI score of 0 following 24 weeks of neoadjuvant anastrozole treatment is at least 95%.

2. To examine the differences in surgical outcome, clinical and radiological response rates, and safety profile between the fulvestrant arm and the anastrozole arm.

3. To examine the differences in surgical outcome, clinical and radiological response rates, and safety profile between patients randomized to fulvestrant in combination with anastrozole and those randomized to anastrozole.

4. To examine the rate of pathologic complete response (pCR) of 12 weeks of neoadjuvant paclitaxel in patients with endocrine resistant disease following 4 weeks or 12 weeks of neoadjuvant endocrine therapy (with either fulvestrant or anastrozole or the combination of fulvestrant and anastrozole).

5. To examine the rate of pathologic complete response (pCR) among those patients with endocrine resistant disease, following 4 weeks or 12 weeks of neoadjuvant endocrine therapy (with either fulvestrant or anastrozole or the combination of fulvestrant and anastrozole), who choose not to receive neoadjuvant paclitaxel, but another standard neoadjuvant taxane and/or anthracycline containing regimen or CMF.

6. To summarize the frequency of severe (NCI CTCAE grade > 3) adverse events encountered with administration of paclitaxel in the neoadjuvant setting.

7. To assess RFS for patients with endocrine resistant tumors defined as: 1) Ki67 > 10% at week 4, 2) Ki67 > 10% at week 12 and 3) modified PEPI score of non-zero on neoadjuvant endocrine therapy, with all three groups combined or separated.

Study Design

• Study Type: Interventional
• Actual Enrollment: 1473 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment (ALTERNATE) in Postmenopausal Women: A Phase III Study
• Actual Study Start Date: Dec 13, 2013
• Anticipated Primary Completion Date: Aug 31, 2025

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Arm I (anastrozole) Patients receive anastrozole daily for 6 cycles followed by surgery. A treatment cycle is 4 weeks in length. After completion of analysis of endocrine resistant data, patients will continue treatment as defined in the protocol.	Drug: anastrozole; Anastrozole 1 mg oral tablet; Other Names: Arimidex®
Active Comparator: Arm II (fulvestrant) Patients receive fulvestrant on days 1 and 15 of cycle 1 and day 1 of cycles 2-6 followed by surgery. A treatment cycle is 4 weeks in length. After completion of analysis of endocrine resistant data, patients will continue treatment as defined in the protocol.	Drug: fulvestrant; Fulvestrant 500 mg IM; Other Names: Faslodex®
Active Comparator: Arm III (anastrozole and fulvestrant) Patients receive anastrozole daily in combination with fulvestrant on days 1 and 15 of cycle 1, and on day 1 of cycles 2-6 followed by surgery. A treatment cycle is 4 weeks in length. After completion of analysis of endocrine resistant data, patients will continue treatment as defined in the protocol.	Drug: fulvestrant; Fulvestrant 500 mg IM; Other Names: Faslodex® ; Drug: anastrozole; Anastrozole 1 mg oral tablet; Other Names: Arimidex®

Outcome Measures

Primary Outcome Measures

1. Rate of endocrine resistant disease-(First Phase) [Up to 24 weeks]

2. Pathologic complete response rate-(pCR rate) [Up to 24 weeks]

3. Recurrence-free survival (RFS)-(Second Phase) [Up to 5 years]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1. Female ≥18 years of age

2. Eastern Cooperative Oncology Group (ECOG) performance status 0-2

3. Postmenopausal, verified by:

• post bilateral surgical oophorectomy or

• no spontaneous menses ≥ 1 year or

• no menses for < 1 year with follicle-stimulating hormone (FSH) and estradiol levels in postmenopausal range, according to institutional standards

1. Pathologic confirmation of invasive breast cancer diagnosed by core needle biopsy

2. Clinical T2-T4c, any N, M0 invasive breast cancer, by AJCC 7th edition clinical staging, with the goal being surgery to complete excision of the tumor in the breast and the lymph node. Primary tumor must be:

• palpable

• its largest diameters is at least 2.0 cm by physical examination or by radiological assessment

Note:

• Patients with contralateral ductal carcinoma in situ and/or invasive breast cancer are not eligible.

• Patients with multi-centric breast cancer (defined as more than one lesion is invasive breast cancer in the same breast separated by ≥ 2 cm of normal breast tissue are not eligible.

1. Invasive breast cancer is estrogen receptor positive with an Allred score of 6, 7 or 8 by local institution standard protocol. If an Allred Score is not reported on the diagnostic pathology report, ER positivity in > 66% cells is eligible. If ER positivity is ≤ 66%, the staining intensity (weak, intermediate, strong) is needed to calculate the Allred Score to determine eligibility.

2. Invasive breast cancer is Human Epidermal Growth Factor Receptor 2 (HER2)- A patient is considered to have HER2 negative breast cancer if one of the following applies:

• 0 or 1+ by immunohistochemistry (IHC) and ISH not done

• 0 or 1+ by IHC and ISH ratio (HER2 gene copy/chromosome 17) < 2

• 2+ by IHC and ISH ratio (HER2 gene copy/chromosome 17) < 2

1. Documentation of mammogram and ultrasound (including ductal carcinoma in situ (DCIS) and invasive cancer) of the diseased breast performed within 56 days prior to registration. Mammogram for the unaffected contralateral breast is required within 12 months prior to registration.

2. Laboratory values (≤ 14 days prior to registration):

3. Absolute Neutrophil Count (ANC) > 1000/mm^3

4. Platelet Count > 100,000/mm^3

5. Total Bilirubin < 1.5 x upper limits of normal (ULN)

6. Creatinine < 1.5 x ULN

7. Serum alanine transaminase (ALT) < 2.5 x ULN

8. Tissue acquisition: Patient must agree to provide the required research biopsies at baseline, week 4 and at surgery for integral and integrated biomarker and correlative studies.

Exclusion Criteria:

1. Premenopausal status

2. Inflammatory breast cancer defined as clinically significant erythema of the breast and/or documented dermal lymphatic invasion (not direct skin invasion by tumor or peau d' orange without erythema).

3. An excisional biopsy of this breast cancer.

4. Hormone replacement therapy of any type, megestrol acetate, or raloxifene within one week prior to registration.

5. Tumor estrogen receptor (ER) Allred score between 0-5 or HER2 positive by IHC (3+) or amplified by FISH > 2.0.

6. Surgical axillary staging procedure prior to study entry. Note: Fine needle aspiration (FNA) or core needle biopsy of axillary node is permitted.

7. Clinical or radiographic evidence of metastatic disease. Metastatic workup is not required, but is recommended for patients with clinical stage III disease. Note: Isolated ipsilateral supraclavicular node involvement is permitted.

8. Breast implants are contraindicated only if the implant precludes the required research biopsies or interferes with palpating the breast lesion.

9. Treatment for this cancer including surgery, radiation therapy, chemotherapy, biotherapy, hormonal therapy or investigational agent prior to study entry.

10. History of invasive breast cancer or contralateral DCIS.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	University of South Alabama Mitchell Cancer Institute	Mobile	Alabama	United States	36688
3	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
4	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
5	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
6	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
7	Alaska Regional Hospital	Anchorage	Alaska	United States	99508
8	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
9	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
10	Katmai Oncology Group	Anchorage	Alaska	United States	99508
11	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
12	University of Arizona Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
13	Mayo Clinic Hospital	Phoenix	Arizona	United States	85054
14	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
15	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
16	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
17	Yuma Cancer Center	Yuma	Arizona	United States	85364
18	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
19	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
20	Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
21	Highlands Oncology Group-Rogers	Rogers	Arkansas	United States	72758
22	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
23	PCR Oncology	Arroyo Grande	California	United States	93420
24	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
25	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
26	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
27	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
28	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
29	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
30	East Bay Radiation Oncology Center	Castro Valley	California	United States	94546
31	Eden Hospital Medical Center	Castro Valley	California	United States	94546
32	Valley Medical Oncology Consultants-Castro Valley	Castro Valley	California	United States	94546
33	Community Cancer Institute	Clovis	California	United States	93611
34	University Oncology Associates	Clovis	California	United States	93611
35	Sutter Davis Hospital	Davis	California	United States	95616
36	Epic Care-Dublin	Dublin	California	United States	94568
37	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
38	Epic Care Partners in Cancer Care	Emeryville	California	United States	94608
39	Kaiser Permanente-Fremont	Fremont	California	United States	94538
40	Palo Alto Medical Foundation-Fremont	Fremont	California	United States	94538
41	Valley Medical Oncology Consultants-Fremont	Fremont	California	United States	94538
42	Kaiser Permanente-Fresno	Fresno	California	United States	93720
43	Saint Jude Medical Center	Fullerton	California	United States	92835
44	Loma Linda University Medical Center	Loma Linda	California	United States	92354
45	Cedars Sinai Medical Center	Los Angeles	California	United States	90048
46	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
47	Memorial Medical Center	Modesto	California	United States	95355
48	Kaiser Permanente-Modesto	Modesto	California	United States	95356
49	El Camino Hospital	Mountain View	California	United States	94040
50	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
51	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
52	Sutter Cancer Research Consortium	Novato	California	United States	94945
53	Highland General Hospital	Oakland	California	United States	94602
54	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
55	Bay Area Tumor Institute	Oakland	California	United States	94609
56	Hematology and Oncology Associates-Oakland	Oakland	California	United States	94609
57	Tom K Lee Inc	Oakland	California	United States	94609
58	Kaiser Permanente-Oakland	Oakland	California	United States	94611
59	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
60	East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill	Pleasant Hill	California	United States	94523
61	Valley Medical Oncology Consultants	Pleasanton	California	United States	94588
62	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
63	Kaiser Permanente-Richmond	Richmond	California	United States	94801
64	Kaiser Permanente-Roseville	Roseville	California	United States	95661
65	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
66	Sutter Roseville Medical Center	Roseville	California	United States	95661
67	Kaiser Permanente Downtown Commons	Sacramento	California	United States	95814
68	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
69	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
70	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
71	Saint Helena Hospital	Saint Helena	California	United States	94574
72	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
73	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
74	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
75	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
76	Doctors Medical Center- JC Robinson Regional Cancer Center	San Pablo	California	United States	94806
77	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
78	Kaiser San Rafael-Gallinas	San Rafael	California	United States	94903
79	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
80	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
81	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
82	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
83	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
84	Kaiser Permanente-Stockton	Stockton	California	United States	95210
85	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
86	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
87	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
88	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
89	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
90	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
91	Epic Care Cyberknife Center	Walnut Creek	California	United States	94597
92	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
93	The Medical Center of Aurora	Aurora	Colorado	United States	80012
94	University of Colorado Hospital	Aurora	Colorado	United States	80045
95	Boulder Community Hospital	Boulder	Colorado	United States	80301
96	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
97	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
98	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
99	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
100	Memorial Hospital North	Colorado Springs	Colorado	United States	80920
101	Denver Health Medical Center	Denver	Colorado	United States	80204
102	The Women's Imaging Center	Denver	Colorado	United States	80209
103	Porter Adventist Hospital	Denver	Colorado	United States	80210
104	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
105	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
106	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
107	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
108	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
109	Rose Medical Center	Denver	Colorado	United States	80220
110	Mercy Medical Center	Durango	Colorado	United States	81301
111	Southwest Oncology PC	Durango	Colorado	United States	81301
112	Comprehensive Cancer Care and Research Institute of Colorado LLC	Englewood	Colorado	United States	80113
113	Swedish Medical Center	Englewood	Colorado	United States	80113
114	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
115	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
116	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
117	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
118	North Colorado Medical Center	Greeley	Colorado	United States	80631
119	Rocky Mountain Cancer Centers-Greenwood Village	Greenwood Village	Colorado	United States	80111
120	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
121	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
122	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
123	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
124	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
125	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
126	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
127	Longmont United Hospital	Longmont	Colorado	United States	80501
128	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
129	McKee Medical Center	Loveland	Colorado	United States	80539
130	Parker Adventist Hospital	Parker	Colorado	United States	80138
131	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
132	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
133	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
134	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
135	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
136	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
137	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
138	Yale-New Haven Shoreline Medical Center	Guilford	Connecticut	United States	06437
139	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
140	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
141	Yale University	New Haven	Connecticut	United States	06520
142	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
143	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
144	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
145	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
146	Lawrence and Memorial Cancer Center	Waterford	Connecticut	United States	06385
147	Beebe Medical Center	Lewes	Delaware	United States	19958
148	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
149	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
150	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
151	Regional Hematology and Oncology PA	Newark	Delaware	United States	19713
152	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
153	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
154	Nanticoke Memorial Hospital	Seaford	Delaware	United States	19973
155	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
156	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
157	MedStar Washington Hospital Center	Washington	District of Columbia	United States	20010
158	Morton Plant Hospital	Clearwater	Florida	United States	33756
159	Baptist MD Anderson Cancer Center	Jacksonville	Florida	United States	32207
160	University Cancer and Blood Center LLC	Athens	Georgia	United States	30607
161	Augusta Oncology Associates PC-D'Antignac	Augusta	Georgia	United States	30901
162	Augusta Oncology Associates PC-Wheeler	Augusta	Georgia	United States	30909
163	Augusta University Medical Center	Augusta	Georgia	United States	30912
164	John B Amos Cancer Center	Columbus	Georgia	United States	31904
165	Dekalb Medical Center	Decatur	Georgia	United States	30033
166	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
167	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
168	Saint Luke's Mountain States Tumor Institute	Boise	Idaho	United States	83712
169	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
170	Kootenai Medical Center	Coeur d'Alene	Idaho	United States	83814
171	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
172	Saint Luke's Mountain States Tumor Institute - Fruitland	Fruitland	Idaho	United States	83619
173	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
174	Saint Luke's Mountain States Tumor Institute - Meridian	Meridian	Idaho	United States	83642
175	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
176	Saint Luke's Mountain States Tumor Institute - Nampa	Nampa	Idaho	United States	83686
177	Kootenai Cancer Center	Post Falls	Idaho	United States	83854
178	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
179	Saint Luke's Mountain States Tumor Institute-Twin Falls	Twin Falls	Idaho	United States	83301
180	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
181	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
182	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
183	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
184	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
185	SIH Cancer Institute	Carterville	Illinois	United States	62918
186	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
187	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
188	Mount Sinai Hospital Medical Center	Chicago	Illinois	United States	60608
189	University of Illinois	Chicago	Illinois	United States	60612
190	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
191	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
192	Advocate Illinois Masonic Medical Center	Chicago	Illinois	United States	60657
193	Carle on Vermilion	Danville	Illinois	United States	61832
194	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
195	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
196	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
197	Crossroads Cancer Center	Effingham	Illinois	United States	62401
198	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
199	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
200	Saint Francis Hospital	Evanston	Illinois	United States	60202
201	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
202	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
203	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
204	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
205	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
206	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
207	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
208	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
209	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
210	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
211	Loyola University Medical Center	Maywood	Illinois	United States	60153
212	Illinois CancerCare-Monmouth	Monmouth	Illinois	United States	61462
213	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
214	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
215	Community Cancer Center Foundation	Normal	Illinois	United States	61761
216	Advocate Christ Medical Center	Oak Lawn	Illinois	United States	60453-2699
217	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
218	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
219	Ottawa Regional Hospital and Healthcare Center	Ottawa	Illinois	United States	61350
220	Radiation Oncology of Northern Illinois	Ottawa	Illinois	United States	61350
221	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
222	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
223	Proctor Hospital	Peoria	Illinois	United States	61614
224	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
225	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
226	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
227	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
228	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
229	Valley Radiation Oncology	Peru	Illinois	United States	61354
230	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
231	SwedishAmerican Regional Cancer Center/ACT	Rockford	Illinois	United States	61114
232	North Shore Medical Center	Skokie	Illinois	United States	60076
233	Central Illinois Hematology Oncology Center	Springfield	Illinois	United States	62702
234	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
235	Springfield Clinic	Springfield	Illinois	United States	62702
236	Memorial Medical Center	Springfield	Illinois	United States	62781
237	Cancer Care Specialists of Illinois-Swansea	Swansea	Illinois	United States	62226
238	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
239	Carle Cancer Center	Urbana	Illinois	United States	61801
240	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
241	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
242	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
243	IU Health North Hospital	Carmel	Indiana	United States	46032
244	Michiana Hematology Oncology PC-Crown Point	Crown Point	Indiana	United States	46307
245	Elkhart Clinic	Elkhart	Indiana	United States	46514-2098
246	Michiana Hematology Oncology PC-Elkhart	Elkhart	Indiana	United States	46514
247	Elkhart General Hospital	Elkhart	Indiana	United States	46515
248	Deaconess Clinic Downtown	Evansville	Indiana	United States	47713
249	IU Health Central Indiana Cancer Centers-Fishers	Fishers	Indiana	United States	46037
250	Parkview Hospital Randallia	Fort Wayne	Indiana	United States	46805
251	Parkview Regional Medical Center	Fort Wayne	Indiana	United States	46845
252	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
253	IU Health Methodist Hospital	Indianapolis	Indiana	United States	46202
254	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
255	IU Health Central Indiana Cancer Centers-East	Indianapolis	Indiana	United States	46219
256	Springmill Medical Center	Indianapolis	Indiana	United States	46290
257	Community Howard Regional Health	Kokomo	Indiana	United States	46904
258	IU Health La Porte Hospital	La Porte	Indiana	United States	46350
259	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
260	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
261	Memorial Regional Cancer Center Day Road	Mishawaka	Indiana	United States	46545
262	Michiana Hematology Oncology PC-Mishawaka	Mishawaka	Indiana	United States	46545
263	Saint Joseph Regional Medical Center-Mishawaka	Mishawaka	Indiana	United States	46545
264	Chancellor Center for Oncology	Newburgh	Indiana	United States	47630
265	Michiana Hematology Oncology PC-Plymouth	Plymouth	Indiana	United States	46563
266	Reid Health	Richmond	Indiana	United States	47374
267	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
268	Michiana Hematology Oncology PC-South Bend	South Bend	Indiana	United States	46601
269	Michiana Hematology Oncology PC-Westville	Westville	Indiana	United States	46391
270	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
271	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
272	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
273	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
274	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
275	Greater Regional Medical Center	Creston	Iowa	United States	50801
276	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
277	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
278	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
279	Mercy Medical Center-Sioux City	Sioux City	Iowa	United States	51102
280	Saint Luke's Regional Medical Center	Sioux City	Iowa	United States	51104
281	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
282	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
283	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
284	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
285	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
286	Menorah Medical Center	Overland Park	Kansas	United States	66209
287	Saint Luke's South Hospital	Overland Park	Kansas	United States	66213
288	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
289	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
290	Baptist Health Corbin	Corbin	Kentucky	United States	40701
291	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
292	Oncology Hematology Care Inc-Crestview	Crestview Hills	Kentucky	United States	41017
293	Saint Elizabeth Medical Center South	Edgewood	Kentucky	United States	41017
294	Saint Elizabeth Fort Thomas	Fort Thomas	Kentucky	United States	41075
295	Baptist Health Lexington	Lexington	Kentucky	United States	40503
296	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
297	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
298	Saint Joseph London	London	Kentucky	United States	40741
299	Jewish Hospital	Louisville	Kentucky	United States	40202
300	Baptist Health Louisville	Louisville	Kentucky	United States	40207
301	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
302	Jewish Hospital Medical Center Northeast	Louisville	Kentucky	United States	40245
303	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
304	Baptist Health Paducah	Paducah	Kentucky	United States	42003
305	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
306	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
307	Eastern Maine Medical Center	Bangor	Maine	United States	04401
308	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
309	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
310	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
311	Sinai Hospital of Baltimore	Baltimore	Maryland	United States	21215
312	MedStar Union Memorial Hospital	Baltimore	Maryland	United States	21218
313	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
314	MedStar Good Samaritan Hospital	Baltimore	Maryland	United States	21239
315	Walter Reed National Military Medical Center	Bethesda	Maryland	United States	20889-5600
316	Western Maryland Regional Medical Center	Cumberland	Maryland	United States	21502
317	UM Baltimore Washington Medical Center/Tate Cancer Center	Glen Burnie	Maryland	United States	21061
318	Northwest Hospital Center	Randallstown	Maryland	United States	21133
319	Peninsula Regional Medical Center	Salisbury	Maryland	United States	21801
320	Holy Cross Hospital	Silver Spring	Maryland	United States	20910
321	William E Kahlert Regional Cancer Center/Sinai Hospital	Westminster	Maryland	United States	21157
322	Brigham and Women's Hospital	Boston	Massachusetts	United States	02115
323	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
324	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
325	MetroWest Medical Center-Framingham Union Hospital	Framingham	Massachusetts	United States	01702
326	Mercy Medical Center	Springfield	Massachusetts	United States	01104
327	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
328	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
329	IHA Hematology Oncology Consultants-Brighton	Brighton	Michigan	United States	48114
330	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
331	IHA Hematology Oncology Consultants-Canton	Canton	Michigan	United States	48188
332	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
333	Caro Cancer Center	Caro	Michigan	United States	48723
334	IHA Hematology Oncology Consultants-Chelsea	Chelsea	Michigan	United States	48118
335	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
336	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
337	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
338	Beaumont Hospital ? Dearborn	Dearborn	Michigan	United States	48124
339	Henry Ford Hospital	Detroit	Michigan	United States	48202
340	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
341	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
342	Beaumont Hospital - Farmington Hills	Farmington Hills	Michigan	United States	48336
343	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
344	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
345	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
346	Hurley Medical Center	Flint	Michigan	United States	48503
347	Helen DeVos Children's Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
348	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
349	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
350	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
351	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
352	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
353	William Beaumont Hospital-Grosse Point	Grosse Pointe	Michigan	United States	48230
354	Allegiance Health	Jackson	Michigan	United States	49201
355	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
356	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
357	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
358	Sparrow Hospital	Lansing	Michigan	United States	48912
359	Hope Cancer Clinic	Livonia	Michigan	United States	48154
360	Saint Mary Mercy Hospital	Livonia	Michigan	United States	48154
361	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
362	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
363	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
364	Mid-Michigan Medical Center - Midland	Midland	Michigan	United States	48670
365	Monroe Cancer Center	Monroe	Michigan	United States	48162
366	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
367	Lakeland Hospital Niles	Niles	Michigan	United States	49120
368	Ascension Providence Hospitals - Novi	Novi	Michigan	United States	48374
369	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
370	Hope Cancer Center	Pontiac	Michigan	United States	48341
371	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
372	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
373	Huron Medical Center PC	Port Huron	Michigan	United States	48060
374	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
375	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
376	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
377	Michigan Cancer Specialists	Roseville	Michigan	United States	48066
378	Oakland Colon and Rectal Association	Royal Oak	Michigan	United States	48067
379	Cancer Care Associates PC	Royal Oak	Michigan	United States	48073
380	Comprehensive Medical Center PLLC	Royal Oak	Michigan	United States	48073
381	Hematology Oncology Consultants PC	Royal Oak	Michigan	United States	48073
382	Oakland Medical Group	Royal Oak	Michigan	United States	48073
383	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
384	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
385	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
386	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
387	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
388	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
389	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
390	Premier Hematology Oncology Care	Sterling Heights	Michigan	United States	48312
391	Mitchell Folbe MD PC	Sterling Heights	Michigan	United States	48314
392	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
393	Munson Medical Center	Traverse City	Michigan	United States	49684
394	Michigan Institute of Urology-Town Center	Troy	Michigan	United States	48084
395	Claudia BR Herke MD PC	Troy	Michigan	United States	48085
396	William Beaumont Hospital - Troy	Troy	Michigan	United States	48085
397	Hematology Oncology Consultants PC-Troy	Troy	Michigan	United States	48098
398	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
399	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
400	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
401	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
402	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
403	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
404	Metro Health Hospital	Wyoming	Michigan	United States	49519
405	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
406	IHA Hematology Oncology Consultants-Ann Arbor	Ypsilanti	Michigan	United States	48197
407	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
408	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
409	Fairview-Southdale Hospital	Edina	Minnesota	United States	55435
410	Unity Hospital	Fridley	Minnesota	United States	55432
411	Hutchinson Area Health Care	Hutchinson	Minnesota	United States	55350
412	Fairview Maple Grove Medical Center	Maple Grove	Minnesota	United States	55369
413	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
414	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
415	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
416	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
417	Health Partners Inc	Minneapolis	Minnesota	United States	55454
418	Monticello Cancer Center	Monticello	Minnesota	United States	55362
419	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
420	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
421	Mayo Clinic	Rochester	Minnesota	United States	55905
422	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
423	Regions Hospital	Saint Paul	Minnesota	United States	55101
424	United Hospital	Saint Paul	Minnesota	United States	55102
425	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
426	Lakeview Hospital	Stillwater	Minnesota	United States	55082
427	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
428	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
429	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
430	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
431	Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	United States	39705
432	Baptist Cancer Center-Grenada	Grenada	Mississippi	United States	38901
433	Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	United States	38652
434	Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	United States	38655
435	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	United States	38671
436	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
437	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
438	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
439	Cox Cancer Center Branson	Branson	Missouri	United States	65616
440	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
441	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
442	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
443	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
444	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
445	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
446	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
447	Freeman Health System	Joplin	Missouri	United States	64804
448	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
449	Saint Luke's Hospital of Kansas City	Kansas City	Missouri	United States	64111
450	Heartland Hematology and Oncology Associates Incorporated	Kansas City	Missouri	United States	64118
451	Research Medical Center	Kansas City	Missouri	United States	64132
452	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
453	Liberty Radiation Oncology Center	Liberty	Missouri	United States	64068
454	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
455	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
456	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64507
457	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
458	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
459	Mercy Hospital South	Saint Louis	Missouri	United States	63128
460	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
461	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
462	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
463	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
464	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
465	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
466	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
467	CoxHealth South Hospital	Springfield	Missouri	United States	65807
468	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
469	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
470	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
471	Billings Clinic Cancer Center	Billings	Montana	United States	59101
472	Saint Vincent Healthcare	Billings	Montana	United States	59101
473	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
474	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
475	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
476	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
477	Great Falls Clinic	Great Falls	Montana	United States	59405
478	Saint Peter's Community Hospital	Helena	Montana	United States	59601
479	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
480	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
481	Community Medical Hospital	Missoula	Montana	United States	59804
482	Nebraska Medicine-Bellevue	Bellevue	Nebraska	United States	68123
483	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
484	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
485	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
486	Nebraska Hematology and Oncology	Lincoln	Nebraska	United States	68506
487	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
488	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
489	Southeast Nebraska Cancer Center	Lincoln	Nebraska	United States	68510
490	Faith Regional Health Services Carson Cancer Center	Norfolk	Nebraska	United States	68701
491	Great Plains Health Callahan Cancer Center	North Platte	Nebraska	United States	69101
492	Nebraska Medicine-Village Pointe	Omaha	Nebraska	United States	68118
493	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
494	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
495	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
496	Nebraska Cancer Specialists - Omaha	Omaha	Nebraska	United States	68124
497	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
498	Oncology Hematology West PC	Omaha	Nebraska	United States	68130
499	Creighton University Medical Center	Omaha	Nebraska	United States	68131
500	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
501	Midlands Community Hospital	Papillion	Nebraska	United States	68046
502	Regional West Medical Center Cancer Center	Scottsbluff	Nebraska	United States	69361
503	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
504	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
505	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
506	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
507	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
508	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
509	21st Century Oncology-Henderson	Henderson	Nevada	United States	89074
510	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
511	Desert West Surgery	Las Vegas	Nevada	United States	89102
512	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
513	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
514	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
515	OptumCare Cancer Care at Oakey	Las Vegas	Nevada	United States	89106
516	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
517	21st Century Oncology	Las Vegas	Nevada	United States	89109
518	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
519	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
520	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
521	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
522	Cancer Therapy and Integrative Medicine	Las Vegas	Nevada	United States	89121
523	21st Century Oncology-Vegas Tenaya	Las Vegas	Nevada	United States	89128
524	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
525	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
526	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
527	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
528	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
529	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
530	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
531	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
532	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
533	21st Century Oncology-Fort Apache	Las Vegas	Nevada	United States	89148
534	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
535	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
536	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
537	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
538	University Cancer Center	Las Vegas	Nevada	United States	89169
539	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
540	Renown Regional Medical Center	Reno	Nevada	United States	89502
541	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
542	Radiation Oncology Associates	Reno	Nevada	United States	89509
543	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
544	New Hampshire Oncology Hematology PA-Hooksett	Hooksett	New Hampshire	United States	03106
545	LRGHealthcare-Lakes Region General Hospital	Laconia	New Hampshire	United States	03246
546	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
547	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
548	Virtua Memorial	Mount Holly	New Jersey	United States	08060
549	Kennedy Health Systems-Cancer Center	Sewell	New Jersey	United States	08080
550	Holy Name Hospital	Teaneck	New Jersey	United States	07666
551	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
552	Virtua Voorhees	Voorhees	New Jersey	United States	08043
553	Inspira Medical Center Woodbury	Woodbury	New Jersey	United States	08096
554	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
555	New Mexico Oncology Hematology Consultants	Albuquerque	New Mexico	United States	87109
556	Presbyterian Kaseman Hospital	Albuquerque	New Mexico	United States	87110
557	Presbyterian Rust Medical Center/Jorgensen Cancer Center	Rio Rancho	New Mexico	United States	87124
558	Christus Saint Vincent Regional Cancer Center	Santa Fe	New Mexico	United States	87505
559	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
560	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
561	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
562	State University of New York Downstate Medical Center	Brooklyn	New York	United States	11203
563	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
564	Arnot Ogden Medical Center/Falck Cancer Center	Elmira	New York	United States	14905
565	Glens Falls Hospital	Glens Falls	New York	United States	12801
566	Mount Sinai Union Square	New York	New York	United States	10003
567	Mount Sinai West	New York	New York	United States	10019
568	Mount Sinai Hospital	New York	New York	United States	10029
569	University of Rochester	Rochester	New York	United States	14642
570	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
571	SUNY Upstate Medical Center-Community Campus	Syracuse	New York	United States	13215
572	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
573	AdventHealth Infusion Center Asheville	Asheville	North Carolina	United States	28803
574	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
575	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
576	Carolina Surgical Clinic of Charlotte PA	Charlotte	North Carolina	United States	28207
577	Oncology Specialists of Charlotte	Charlotte	North Carolina	United States	28207
578	Southern Oncology Specialists-Charlotte	Charlotte	North Carolina	United States	28262
579	Sampson Radiation Oncology	Clinton	North Carolina	United States	28328
580	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
581	AdventHealth Infusion Center Haywood	Clyde	North Carolina	United States	28721
582	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
583	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
584	Wayne Radiation Oncology	Goldsboro	North Carolina	United States	27534
585	East Carolina University	Greenville	North Carolina	United States	27834
586	AdventHealth Hendersonville	Hendersonville	North Carolina	United States	28792
587	University of North Carolina-Hillsborough Campus	Hillsborough	North Carolina	United States	27278
588	Lake Norman Hematology Oncology Specialists-Huntersville	Huntersville	North Carolina	United States	28078
589	Southern Oncology Specialists-Huntersville	Huntersville	North Carolina	United States	28078
590	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
591	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
592	Vidant Oncology-Kenansville	Kenansville	North Carolina	United States	28349
593	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
594	Matthews Radiation Oncology Center	Matthews	North Carolina	United States	28105
595	Novant Health Cancer Specialists-Matthews	Matthews	North Carolina	United States	28105
596	Lake Norman Hematology Oncology Specialists-Mooresville	Mooresville	North Carolina	United States	28117
597	Vidant Oncology-Richlands	Richlands	North Carolina	United States	28574
598	Iredell Memorial Hospital	Statesville	North Carolina	United States	28677
599	Southeastern Medical Oncology Center-Wilson	Wilson	North Carolina	United States	27893
600	Wake Forest University Health Sciences	Winston-Salem	North Carolina	United States	27157
601	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
602	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
603	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
604	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
605	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
606	Miami Valley Hospital South	Centerville	Ohio	United States	45459
607	Geauga Hospital	Chardon	Ohio	United States	44024
608	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
609	Oncology Hematology Care Inc-Eden Park	Cincinnati	Ohio	United States	45202
610	Oncology Hematology Care Inc-Mercy West	Cincinnati	Ohio	United States	45211
611	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
612	Oncology Hematology Care Inc - Anderson	Cincinnati	Ohio	United States	45230
613	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
614	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
615	Oncology Hematology Care Inc-Blue Ash	Cincinnati	Ohio	United States	45242
616	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
617	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
618	Case Western Reserve University	Cleveland	Ohio	United States	44106
619	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
620	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
621	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
622	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
623	Grant Medical Center	Columbus	Ohio	United States	43215
624	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
625	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
626	Doctors Hospital	Columbus	Ohio	United States	43228
627	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
628	Miami Valley Hospital	Dayton	Ohio	United States	45409
629	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
630	Miami Valley Hospital North	Dayton	Ohio	United States	45415
631	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
632	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
633	Grady Memorial Hospital	Delaware	Ohio	United States	43015
634	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
635	Oncology Hematology Care Inc-Healthplex	Fairfield	Ohio	United States	45014
636	Armes Family Cancer Center	Findlay	Ohio	United States	45840
637	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
638	Orion Cancer Care	Findlay	Ohio	United States	45840
639	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
640	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
641	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
642	Wayne Hospital	Greenville	Ohio	United States	45331
643	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
644	First Dayton Cancer Care	Kettering	Ohio	United States	45420
645	Kettering Medical Center	Kettering	Ohio	United States	45429
646	Fairfield Medical Center	Lancaster	Ohio	United States	43130
647	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
648	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
649	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
650	UH Seidman Cancer Center at Landerbrook Health Center	Mayfield Heights	Ohio	United States	44124
651	UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	United States	44060
652	UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	United States	44130
653	Dayton Physicians LLC-Signal Point	Middletown	Ohio	United States	45042
654	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
655	Licking Memorial Hospital	Newark	Ohio	United States	43055
656	Newark Radiation Oncology	Newark	Ohio	United States	43055
657	University Hospitals Parma Medical Center	Parma	Ohio	United States	44129
658	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
659	UH Seidman Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
660	Dayton Physicians LLC-Wilson	Sidney	Ohio	United States	45365
661	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
662	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
663	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
664	The Toledo Hospital/Toledo Children's Hospital	Toledo	Ohio	United States	43606
665	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
666	Upper Valley Medical Center	Troy	Ohio	United States	45373
667	University Hospitals Sharon Health Center	Wadsworth	Ohio	United States	44281
668	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
669	Saint Ann's Hospital	Westerville	Ohio	United States	43081
670	UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	United States	44145
671	UHHS-Westlake Medical Center	Westlake	Ohio	United States	44145
672	Wright-Patterson Medical Center	Wright-Patterson Air Force Base	Ohio	United States	45433-5529
673	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
674	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
675	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
676	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
677	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
678	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
679	Saint Charles Health System	Bend	Oregon	United States	97701
680	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
681	Providence Oncology and Hematology Care Southeast	Clackamas	Oregon	United States	97015
682	Bay Area Hospital	Coos Bay	Oregon	United States	97420
683	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
684	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
685	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
686	Providence Willamette Falls Medical Center	Oregon City	Oregon	United States	97045
687	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
688	Providence Portland Medical Center	Portland	Oregon	United States	97213
689	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
690	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
691	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
692	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
693	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
694	UPMC-Heritage Valley Health System Beaver	Beaver	Pennsylvania	United States	15009
695	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
696	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
697	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
698	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
699	UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	United States	15601
700	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
701	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
702	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
703	UPMC-Johnstown/John P. Murtha Regional Cancer Center	Johnstown	Pennsylvania	United States	15901
704	Armstrong Center for Medicine and Health	Kittanning	Pennsylvania	United States	16201
705	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
706	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
707	UPMC Cancer Center at UPMC McKeesport	McKeesport	Pennsylvania	United States	15132
708	Forbes Hospital	Monroeville	Pennsylvania	United States	15146
709	UPMC-Coraopolis/Heritage Valley Radiation Oncology	Moon	Pennsylvania	United States	15108
710	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
711	UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	United States	15213
712	UPMC-Presbyterian Hospital	Pittsburgh	Pennsylvania	United States	15213
713	UPMC-Saint Margaret	Pittsburgh	Pennsylvania	United States	15215
714	West Penn Hospital	Pittsburgh	Pennsylvania	United States	15224
715	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
716	UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	United States	15232
717	UPMC Jefferson Regional Radiation Oncology	Pittsburgh	Pennsylvania	United States	15236
718	UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	United States	15237
719	UPMC-Saint Clair Hospital Cancer Center	Pittsburgh	Pennsylvania	United States	15243
720	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
721	Community Medical Center	Scranton	Pennsylvania	United States	18510
722	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
723	UPMC Cancer Center at UPMC Northwest	Seneca	Pennsylvania	United States	16346
724	Geisinger Medical Group	State College	Pennsylvania	United States	16801
725	UPMC Uniontown Hospital Radiation Oncology	Uniontown	Pennsylvania	United States	15401
726	UPMC Washington Hospital Radiation Oncology	Washington	Pennsylvania	United States	15301
727	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
728	Women and Infants Hospital	Providence	Rhode Island	United States	02905
729	Kent Hospital	Warwick	Rhode Island	United States	02886
730	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
731	Roper Hospital	Charleston	South Carolina	United States	29401
732	Charleston Hematology Oncology Associates-Roper	Charleston	South Carolina	United States	29403
733	Lowcountry Hematology Oncology PA-North Charleston	Charleston	South Carolina	United States	29406
734	Bon Secours Saint Francis Hospital	Charleston	South Carolina	United States	29414
735	Charleston Hematology Oncology Associates PA-Saint Francis	Charleston	South Carolina	United States	29414
736	Lowcountry Hematology Oncology PA-West Ashley	Charleston	South Carolina	United States	29414
737	Medical University of South Carolina	Charleston	South Carolina	United States	29425
738	Greenville Health System Cancer Institute-Easley	Easley	South Carolina	United States	29640
739	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
740	Greenville Health System Cancer Institute-Andrews	Greenville	South Carolina	United States	29601
741	Saint Francis Hospital	Greenville	South Carolina	United States	29601
742	Greenville Health System Cancer Institute-Butternut	Greenville	South Carolina	United States	29605
743	Greenville Health System Cancer Institute-Faris	Greenville	South Carolina	United States	29605
744	Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
745	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
746	Greenville Health System Cancer Institute-Eastside	Greenville	South Carolina	United States	29615
747	Greenville Health System Cancer Institute-Greer	Greer	South Carolina	United States	29650
748	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
749	Carolina Blood and Cancer Care Associates PA-Lancaster	Lancaster	South Carolina	United States	29720
750	Lowcountry Hematology Oncology PA-Mount Pleasant	Mount Pleasant	South Carolina	United States	29464
751	Carolina Blood and Cancer Care Associates PA	Rock Hill	South Carolina	United States	29732
752	Greenville Health System Cancer Institute-Seneca	Seneca	South Carolina	United States	29672
753	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
754	Greenville Health System Cancer Institute-Spartanburg	Spartanburg	South Carolina	United States	29307
755	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
756	Memorial Hospital	Chattanooga	Tennessee	United States	37404
757	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
758	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	United States	38120
759	Baptist Memorial Hospital for Women	Memphis	Tennessee	United States	38120
760	Family Cancer Center-Memphis	Memphis	Tennessee	United States	38120
761	Nashville Breast Center	Nashville	Tennessee	United States	37203
762	Meharry Medical College	Nashville	Tennessee	United States	37208
763	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
764	Hendrick Medical Center	Abilene	Texas	United States	79601
765	Austin Cancer Centers-Central Austin	Austin	Texas	United States	78702
766	Austin Cancer Centers-Central Park	Austin	Texas	United States	78705
767	Austin Cancer Centers-Saint David's	Austin	Texas	United States	78705
768	Austin Cancer Centers-Northwest	Austin	Texas	United States	78759
769	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
770	Parkland Memorial Hospital	Dallas	Texas	United States	75235
771	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
772	Texas Tech University Health Sciences Center-El Paso	El Paso	Texas	United States	79905
773	UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	United States	76104
774	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
775	Ben Taub General Hospital	Houston	Texas	United States	77030
776	M D Anderson Cancer Center	Houston	Texas	United States	77030
777	MD Anderson in Katy	Houston	Texas	United States	77094
778	Doctor's Hospital of Laredo	Laredo	Texas	United States	78041
779	MD Anderson League City	Nassau Bay	Texas	United States	77058
780	MD Anderson in Sugar Land	Sugar Land	Texas	United States	77478
781	MD Anderson in The Woodlands	The Woodlands	Texas	United States	77384
782	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
783	University of Vermont Medical Center	Burlington	Vermont	United States	05401
784	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
785	IMG Hematology Oncology 8501	Fairfax	Virginia	United States	22031
786	Hematology Oncology Associates of Fredericksburg Inc	Fredericksburg	Virginia	United States	22408
787	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
788	Shenandoah Oncology PC	Winchester	Virginia	United States	22601
789	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
790	Cancer Care Center at Island Hospital	Anacortes	Washington	United States	98221
791	Swedish Cancer Institute-Eastside Oncology Hematology	Bellevue	Washington	United States	98005
792	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
793	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
794	Harrison Medical Center	Bremerton	Washington	United States	98310
795	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
796	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
797	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
798	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
799	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
800	Saint Francis Hospital	Federal Way	Washington	United States	98003
801	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
802	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
803	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
804	Saint Clare Hospital	Lakewood	Washington	United States	98499
805	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
806	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
807	Minor and James Medical PLLC	Seattle	Washington	United States	98104
808	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
809	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
810	Kaiser Permanente Washington	Seattle	Washington	United States	98112
811	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
812	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
813	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
814	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
815	Rockwood Clinic Cancer Treatment Center-Valley	Spokane Valley	Washington	United States	99216
816	Rockwood Cancer Treatment Center-DHEC-Downtown	Spokane	Washington	United States	99204
817	Evergreen Hematology and Oncology PS	Spokane	Washington	United States	99218
818	Rockwood North Cancer Treatment Center	Spokane	Washington	United States	99218
819	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
820	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
821	Madigan Army Medical Center	Tacoma	Washington	United States	98431
822	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
823	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
824	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
825	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
826	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
827	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
828	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
829	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
830	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
831	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
832	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
833	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
834	Mercy Health System	Janesville	Wisconsin	United States	53547
835	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
836	University of Wisconsin Hospital and Clinics	Madison	Wisconsin	United States	53792
837	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
838	Bay Area Medical Center	Marinette	Wisconsin	United States	54143
839	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
840	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
841	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
842	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
843	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
844	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
845	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
846	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
847	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
848	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
849	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
850	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
851	Aspirus UW Cancer Center	Wisconsin Rapids	Wisconsin	United States	54494
852	Rocky Mountain Oncology	Casper	Wyoming	United States	82609
853	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
854	Big Horn Basin Cancer Center	Cody	Wyoming	United States	82414
855	Billings Clinic-Cody	Cody	Wyoming	United States	82414
856	Welch Cancer Center	Sheridan	Wyoming	United States	82801
857	Cancer Center-Metro Medical Center Bayamon	Bayamon		Puerto Rico	00959-5060
858	Doctors Cancer Center	Manati		Puerto Rico	00674
859	San Juan Community Oncology Group	San Juan		Puerto Rico	00917
860	San Juan City Hospital	San Juan		Puerto Rico	00936

Sponsors and Collaborators

• Alliance for Clinical Trials in Oncology
• National Cancer Institute (NCI)

Investigators

• Study Chair: Cynthia Ma, MD, PhD, Washington University School of Medicine

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Alliance for Clinical Trials in Oncology
• ClinicalTrials.gov Identifier: NCT01953588
• Other Study ID Numbers: A011106; NCI-2013-01340; U10CA031946
• First Posted: Oct 1, 2013
• Last Update Posted: Jul 20, 2021
• Last Verified: Jul 1, 2021

• Additional relevant MeSH terms: Carcinoma; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Fulvestrant; Anastrozole

Study Results

No Results Posted as of Jul 20, 2021