A Pilot Study to Evaluate Multi-Spectral Imaging and Laser Speckle Imaging During Vascular Occlusion

Sponsor

University of California, Irvine (Other)

Overall Status

Withdrawn

CT.gov ID

NCT01484730

Collaborator

Beckman Laser Institute University of California Irvine (Other)

Enrollment

Location

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this research is to evaluate and validate the performance of non-invasive imaging modalities for assessment of skin. A pressure cuff occlusion will be used to stimulate blood flow dynamic that these instruments are designed to sense. The researcher currently plan to assess only basic feasibility of the imaging instruments.

Condition or Disease	Intervention/Treatment	Phase
Abnormal Vascular Flow	Device: Multi-Spectral & Laser Speckle Imaging

Detailed Description

The primary reason for including pressure cuff occlusion in this protocol is to test the performance of Multi-Spectral Imaging and Laser Speckle Imaging can measure in the full range of vascular conditions ranging from ischemic (under-perfused or unsaturated) to hyperemic (over-perfused and over-saturated).

.Modulated Imaging a non-contact optical imaging technology can detect the concentration of total hemoglobin, deoxygenated and oxygenated hemoglobin in absolute amounts in units of millimoles / unit volume of tissue measured.
. Laser Speckle Imaging a non-contact optical imaging technology consists of a coherent light source, camera, and image acquisition system. This image device can measure and compare relative flow in vasculature at varied time points.

Study Design

Study Type:

Observational

Actual Enrollment :

0 participants

Observational Model:

Case-Only

Time Perspective:

Cross-Sectional

Official Title:

A Pilot Study to Evaluate Multi-Spectral Imaging and Laser Speckle Imaging During Vascular Occlusion

Study Start Date :

Nov 1, 2011

Anticipated Primary Completion Date :

Nov 1, 2018

Anticipated Study Completion Date :

Nov 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
Vascular Occulsion Multi-Spectral & Laser Speckle Imaging	Device: Multi-Spectral & Laser Speckle Imaging Changes in skin tissue and blood flow.

Arm

Intervention/Treatment

Vascular Occulsion

Multi-Spectral & Laser Speckle Imaging

Device: Multi-Spectral & Laser Speckle Imaging

Changes in skin tissue and blood flow.

Outcome Measures

Primary Outcome Measures

Skin blood flow [4 weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Male and female adult 18 years and older

Exclusion Criteria:

Younger than 18 years of age
Pregnant women

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Beckman Laser Institute, UCI	Irvine	California	United States	92612

Sponsors and Collaborators

University of California, Irvine
Beckman Laser Institute University of California Irvine

Investigators

Principal Investigator: Anthony Durkin, PhD, Beckman Laser Institute, UCI

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Beckman Laser Institute and Medical Center, Anthony Durkin, Ph.D. Associate Professor, Director, Laboratory for Functional Imaging and Spectroscopy of Superficial Tissues, University of California, Irvine

ClinicalTrials.gov Identifier:

NCT01484730

Other Study ID Numbers:

NIH/LAMMP-2011-8370

First Posted:

Dec 2, 2011

Last Update Posted:

Sep 19, 2017

Last Verified:

Sep 1, 2017

Study Results

No Results Posted as of Sep 19, 2017