Evolution of a Novel Optical Coherence Tomography Based Index in Diagnosing Keratoconus
Study Details
Study Description
Brief Summary
Comparison of corneal topography based on oct OCT principle (CASIA2) with Pentacam and Scheimpflug-based biomechanical devices (Corvis ST) in screening and diagnosing keratoconus; and evaluation of the consistency with Pentacam in measuring corneal parameters (such as curvature and thickness).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Normal control group
|
Other: Pentacam, Corvis ST and CASIA2
morphological and biomechanical parameters of corneal were obtain by CASIA2, Pentacam and Corvis ST
|
| Subclinical keratoconus
|
Other: Pentacam, Corvis ST and CASIA2
morphological and biomechanical parameters of corneal were obtain by CASIA2, Pentacam and Corvis ST
|
| Keratoconus
|
Other: Pentacam, Corvis ST and CASIA2
morphological and biomechanical parameters of corneal were obtain by CASIA2, Pentacam and Corvis ST
|
Outcome Measures
Primary Outcome Measures
- screening and diagnosis ability [one year]
Evaluate the sensitivity and specificity of parameters measured by CASIA2, Pentacam in diagnosing keratoconus using Receiver operating characteristic curves (ROC), and compare the Ectasia Screening Similarity（ESS）and D-value diagnostic efficacy using Area under the ROC curve (AUROC). Use the Delong test to compare the accuracy of various parameters in diagnosing early keratoconus.
Secondary Outcome Measures
- Measurement consistency [one year]
The independent sample T-test is used to compare inter- group differences in baseline data. Use independent sample T-test and One-way ANOVA to evaluate the consistency of the measurement results (anterior and posterior corneal curvature, corneal refractive index, CCT) obtained by CASIA2 and Pentacam.Finally, the ultimate outcome（such ad：K1 K2 KMax CCT） indicates that the P-value between the two devices is less than 0.05 and ICC-value is more than 0.75.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Best corrected visual acuity (BCVA) ≥ 20/20;
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No other eye diseases except myopia and astigmatism;
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The cornea was transparent, and there was no cloud or pannus;
Exclusion Criteria:
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The presence of ocular diseases other than myopia and keratoconus;
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Ocular trauma;
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Previous ocular surgery; 4 Patients were required to stop wearing soft contact lenses for at least 2 weeks and rigid contact lenses for at least 4 weeks before examination;
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Pregnant and lactating women;
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Tiajin Eye Hospital | Tianjin | Tianjin | China |
Sponsors and Collaborators
- Tianjin Eye Hospital
Investigators
- Study Chair: Yan Wang, Prof, Tiajin Eye Hospita
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- KY2023063