The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients
Study Details
Study Description
Brief Summary
The evolution of systemic microvascular reactivity may aid in the comprehension of cardiovascular physiology in heart transplantation patients, and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Introduction: Systemic microvascular reactivity (MR) is an essential component of cardiovascular physiology, being studied through non-invasive techniques in readily accessible body regions, such as the skin surface. Heart transplant (HT) is a treatment considered to selected patients, with advanced heart failure. The main cause of long-term mortality after HT is graft vascular disease (GVD), a condition which starts with endothelial dysfunction. To know the evolution of systemic MR in patients subjected to HT can help to find prognostic factors. Objective: The present study aims to perform the prospective evaluation of systemic MR in adult patients, before and two years after HT, at a quaternary hospital, correlating the findings with clinical variables. Methods: Systemic MR will be evaluated in the skin of the forearm using laser speckle contrast imaging with acetylcholine (ACh) iontophoresis, followed by postocclusive reactive hyperemia (PORH), before and after HT. Measurements will be correlated to patient clinical profile, hemodynamic and echocardiographic data. Expected results: The evolution of systemic MR may aid in the comprehension of cardiovascular physiology in HT patients, and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| heart transplantation
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Diagnostic Test: skin microvascular reactivity
Laser-based method for evaluating non-invasive, operator-independent systemic microvascular function that detects microvascular flow in the skin for the evaluation of systemic vascular endothelial function.
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Outcome Measures
Primary Outcome Measures
- Baseline and post-iontophoresis of acetylcholine endothelium-dependent skin microvascular reactivity [Microvascular reactivity will be evaluated 20-minute rest in the supine position in a temperature-controlled room.]
Evaluation of systemic microvascular reactivity induced by endothelium-dependent agents. Microvascular reactivity will be evaluated using a non-invasive and operator -independent methodology, named laser speckle contrast imaging, coupled with skin iontophoresis of vasodilator agents. Cutaneous microvascular flow will be measured in arbitrary perfusion units, divided by mean arterial pressure, to yield cutaneous vascular conductance.
Eligibility Criteria
Criteria
Inclusion Criteria:
- capability to understand the objectives of the research and to fulfill the Term of Consent
Exclusion Criteria:
- Pregnancy, acute infection diagnosis, use of circulatory assistance devices
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Eduardo Tibiriçá | Rio de Janeiro | Brazil | 22240006 |
Sponsors and Collaborators
- National Institute of Cardiology, Laranjeiras, Brazil
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 45581521.0.0000.5272