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Examining Common Substrates of Eating and Alcohol Use Disorders

Sponsor
New York State Psychiatric Institute (Other)
Overall Status
Completed
CT.gov ID
NCT01172210
Collaborator
(none)
61
Enrollment
1
Location
59
Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. Individuals with BN and alcohol use disorders appear to share some behavioral traits, and therefore, the primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on measures assessing an individual's mood and ability to perform certain tasks. Participants will be asked to complete computer-administered and paper-and-pencil assessments and two laboratory test meals on separate days. By probing the underpinnings of BN and alcohol use disorders, the investigators can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co-occurring alcohol use disorder, an exploratory aim of the current study is evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance our understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. The primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on computer-administered and paper-and-pencil assessments and in two laboratory test meals (a binge meal and a normal meal) on separate days. Participants will also complete self-report and interview measures of eating disorder symptoms and alcohol consumption. By probing the underpinnings of BN and alcohol use disorders, we can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co occurring alcohol use disorder, an exploratory aim of the current study is to evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    61 participants
    Official Title:
    Examining Common Substrates of Eating and Alcohol Use Disorders
    Study Start Date :
    Jul 1, 2009
    Actual Primary Completion Date :
    Jun 1, 2014
    Actual Study Completion Date :
    Jun 1, 2014

    Arms and Interventions

    Arm Intervention/Treatment
    Bulimia Nervosa
    Bulimia Nervosa w/ Alcohol Use Disorder
    Healthy Controls

    Outcome Measures

    Primary Outcome Measures

    1. Eating Behavior [Baseline]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 45 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Age 18-45

    • Diagnosis of bulimia nervosa with or without a co-occurring alcohol use disorder

    • English speaking

    • Weight above 80% of ideal

    Exclusion Criteria:

    • Other significant psychiatric conditions requiring treatment or a significant medical condition

    • Pregnancy

    • Current use of psychotropic medication

    • History of neurological disorder (e.g., dementia, stroke seizure)

    • Food allergy to items in the lunch buffet

    • Positive urine drug screen

    • Current or post eating disorder diagnosis or history of binge eating or vomiting

    • Current or past alcohol or substance abuse or dependence

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 New York State Psychiatric Institute New York New York United States 10032

    Sponsors and Collaborators

    • New York State Psychiatric Institute

    Investigators

    • Principal Investigator: Robyn Sysko, Ph.D., New York State Psychiatric Institute

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    New York State Psychiatric Institute
    ClinicalTrials.gov Identifier:
    NCT01172210
    Other Study ID Numbers:
    • #5973/6951R
    First Posted:
    Jul 29, 2010
    Last Update Posted:
    Aug 21, 2014
    Last Verified:
    Apr 1, 2013
    Additional relevant MeSH terms:
    Bulimia
    Alcoholism
    Alcohol Drinking
    Bulimia Nervosa

    Study Results

    No Results Posted as of Aug 21, 2014