Examining the Link Between Obesity, Inflammation, and Response to Asthma Medications
Study Details
Study Description
Brief Summary
Asthma is a common, long-term disease that is caused by inflammation of the airways. Inflammation also plays a role in obesity and may affect the way a person responds to asthma medication. This study will examine the relationship between obesity and inflammation and the effect they have on response to corticosteroid asthma medications.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Asthma affects 20 million people in the United States. It can be caused by many factors, including exposure to tobacco smoke, infections, and other allergens. Recent research suggests that there may be a relationship between obesity and asthma. It is not fully understood how these two conditions are linked, but inflammation may play a role. Obesity-related inflammation may increase the risk of airway inflammation, thereby elevating the risk of developing asthma. Increased inflammation related to obesity may also reduce the effectiveness of inhaled steroid asthma medications, including glucocorticoids. Compared with people of normal weight, people who are overweight or obese may have a higher risk of developing glucocorticoid insensitivity, resulting in intolerance to glucocorticoid medications. The purpose of this study is to examine the effect that obesity has on glucocorticoid insensitivity and inflammation. This study will also examine differences in the response to asthma steroid medications between people who are overweight or obese and those who are not.
This study will use previously collected data from participants in two clinical trials of the NHLBI-funded Asthma Clinical Research Network (ACRN): the Best Adjustment Strategy for Asthma in Long Term (BASALT) study (NCT00495157) and the Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC) study. There will be no additional study visits specifically for this study. Researchers will examine blood samples collected at participants' first BASALT or TALC study visit to analyze levels of inflammation biomarkers (including tumor necrosis factor-alpha [TNF-α], interleukin-6 [IL-6], and leptin) and proinflammatory cytokines levels, which influence glucocorticoid insensitivity. Additional BASALT and TALC study data, including lung function, asthma symptoms, and asthma exacerbations, will also be analyzed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| BASALT Participants in the ACRN BASALT study |
Drug: Beclomethasone dipropionate HFA
Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation
Other Names:
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| TALC Participants in the ACRN TALC study |
Drug: Tiotropium bromide
Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation
Other Names:
Drug: Salmeterol xinafoate
Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation
Other Names:
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Outcome Measures
Primary Outcome Measures
- Measures of lung function; asthma symptoms and exacerbations; quality of life; rescue medication usage; inflammation and oxidative stress biomarkers; and the effect these factors have on glucocorticoid insensitivity [Measured at Week 36 for BASALT participants and Week 46 for TALC participants]
Eligibility Criteria
Criteria
Inclusion Criteria:
Participation in either the BASALT or TALC studies of the Asthma Clinical Research Network. Inclusion and exclusion criteria are as determined by those studies, NCT00495157, NCT00565266.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of California, San Diego | San Diego | California | United States | 92093 |
| 2 | University of California, San Francisco | San Francisco | California | United States | 94143 |
| 3 | National Jewish Medical & Research Center | Denver | Colorado | United States | 80206 |
| 4 | Brigham & Women's Hospital | Boston | Massachusetts | United States | 02115 |
| 5 | Washington University | Saint Louis | Missouri | United States | 63130 |
| 6 | Columbia University Medical Center | New York | New York | United States | 10032 |
| 7 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 8 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 9 | University of Texas Medical Branch | Galveston | Texas | United States | 77555 |
| 10 | University of Wisconsin | Madison | Wisconsin | United States | 53706 |
Sponsors and Collaborators
- National Jewish Health
- National Heart, Lung, and Blood Institute (NHLBI)
Investigators
- Principal Investigator: E. R. Sutherland, MD, MPH, National Jewish Medical & Research Center
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- 1423
- R01HL090982