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Exercise Changes to Peripheral Blood Mononuclear Cells in Children

Sponsor
University of California, Irvine (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00585403
Collaborator
(none)
0
Enrollment
1
Location

Study Details

Study Description

Brief Summary

The goal of this research is to determine how the peripheral immune system is altered by exercise and differences related to gender, pubertal status and health.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    SPECIFIC AIMS:

    1. To systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on:

    2. Numbers of circulating PMBCs, their subsets and key intercellular adhesion molecules (ICAMs).

    3. PBMC gene regulation of stress, inflammatory, and growth/repair mediators [including: interleukin-4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma), growth hormone (GH), insulin-like growth factor-I (IGF-I), heat shock proteins (Hsp)].

    4. Circulating (serum) and intracellular PBMC levels of key mediators by flow cytometry and cell culture techniques.

    5. Circulating endogenous triggers of PBMC mediator responses-soluble Hsp, IL-6, and F2-isoprostanes.

    6. To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).

    7. To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    0 participants
    Observational Model:
    Cohort
    Time Perspective:
    Cross-Sectional
    Official Title:
    PBMC, Exercise and Children: Initial Mechanisms
    Study Start Date :
    Dec 1, 2004
    Actual Primary Completion Date :
    Dec 1, 2004
    Actual Study Completion Date :
    Dec 1, 2004

    Arms and Interventions

    Arm Intervention/Treatment
    Children

    Early and late pubertal girls and boys

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      8 Years to 18 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • appropriate Tanner Stage

      • No evidence of disease or disability

      Exclusion Criteria:

      • no use of antiinflammatory medications, alcohol, illegal drugs or bronchodilators

      • elite children participating in extensive exercise or dance programs

      • pregnant

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 General Clinical Research Center Orange California United States 92868

      Sponsors and Collaborators

      • University of California, Irvine

      Investigators

      • Principal Investigator: Dan M Cooper, M.D., Univ. California, Irvine, CA

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      University of California, Irvine
      ClinicalTrials.gov Identifier:
      NCT00585403
      Other Study ID Numbers:
      • PBMC Exercise [2004-3967]
      • HL-80947
      First Posted:
      Jan 3, 2008
      Last Update Posted:
      Jan 25, 2021
      Last Verified:
      Jan 1, 2021

      Study Results

      No Results Posted as of Jan 25, 2021