The Effect of Acute Resistance Exercise on Inhibitory Control

Sponsor
National Taiwan Normal University (Other)
Overall Status
Recruiting
CT.gov ID
NCT05311202
Collaborator
(none)
175
1
5
9
19.4

Study Details

Study Description

Brief Summary

The current study is a five-arm, single bout program aiming to assess the effects of training volume and intensity of acute resistance exercise on inhibitory control on neurocognitive function with respect to event-related potential in adults aged 20 - 26 years.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: low-volume moderate-intensity group
  • Behavioral: moderate-volume moderate-intensity group
  • Behavioral: high-volume moderate-intensity group
  • Behavioral: moderate-volume low-intensity group
  • Behavioral: Control group
N/A

Detailed Description

The current study is expected that 175 healthy adults will be recruited and randomly assigned to control group, low volume-moderate intensity, moderate volume-moderate intensity, high volume-moderate intensity, or moderate volume-low intensity group, with 35 participants in each group. Participants will be required to conduct two experiments. The first was the familiarity experiment, which consisted of the experiment description, the familiarity test, and the 6 Repetition Maximum (RM) test. The process lasted about 3 hours. The exercise group was given a warm-up exercise before the intervention, followed by resistance exercise, including Bench Press, Rowing, Deadlift, and Squat, all completed on the Smith machine. After the exercise, the group was given a cool down, while the control group was given 30 minutes of reading. Before and after the intervention, Stroop, event-related potential and fingertip blood lactate were measured, and another fingertip blood lactate was measured 10 minutes after the intervention, which lasted about 3 hours.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
175 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Health Services Research
Official Title:
The Effect of Training Volume and Intensity of Acute Resistance Exercise on Inhibitory Control: An Event-Related Potential Study
Actual Study Start Date :
Apr 1, 2022
Anticipated Primary Completion Date :
Sep 30, 2022
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
Experimental: low-volume moderate-intensity group

Participants will attend the trainer-supervised resistance exercise program for 30 minutes

Behavioral: low-volume moderate-intensity group
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 20 minutes of two sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down

Experimental: moderate-volume moderate-intensity group

Participants will attend the trainer-supervised resistance exercise program for 40 minutes

Behavioral: moderate-volume moderate-intensity group
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 30 minutes of three sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down

Experimental: high-volume moderate-intensity group

Participants will attend the trainer-supervised resistance exercise program for 50 minutes

Behavioral: high-volume moderate-intensity group
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 40 minutes of four sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down

Experimental: moderate-volume low-intensity group

Participants will attend the trainer-supervised resistance exercise program for 45 minutes

Behavioral: moderate-volume low-intensity group
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 35 minutes of four sets of low intensity resistance exercise with 20 repetitions; (3) 5 minutes of cool down

Experimental: Control group

Reading for 40 minutes

Behavioral: Control group
Reading a book related to cognitive function & exercise for 40 minutes

Outcome Measures

Primary Outcome Measures

  1. Changes In Inhibitory Control [30 minutes each before & after intervention]

    The computerized Stroop test will be administrated to assess participants' inhibitory function, and the changes in Emotional Stroop test performance (i.e., response time and accuracy) before (pre-test) and after (post-test) intervention will be examined.

  2. Changes In Neuroelectrical Activities: Event-Related Potential Recording and Analysis [30 minutes each before & after intervention]

    The continuous electroencephalogram (EEG) activity of each participant will be recorded throughout the entire Stroop task using a Neuroscan Quick-Cap, with 32 Ag/AgCl electrodes arranged following the international 10-20 system (NeuroScan Inc., El Paso, TX, USA). Changes in the neuroelectrical activities before and after the intervention will be examined. The time windows for each ERP component will be determined based on a visual inspection of the averaged grand waveform.

Secondary Outcome Measures

  1. Changes In Positive & Negative Affect [5 minutes after pre-test and post-test of Stroop test]

    The changes in the Positive & Negative affect after pre-and post-test will be assessed by The Positive and Negative Affect Schedule (PANAS) questionnaire, which is made up of two 10-item scales that assess both positive and negative emotions. Each item is scored on a scale of 1 (not at all) to 5 (very much).

  2. Muscular Fitness Measurements (1RM)-Deadlift [2 hours on the first day]

    The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 10-20% for lower body exercises. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. The 1RM will be caculated by the results of 6-RM protocol.

  3. Muscular Fitness Measurements (1RM)-Bench Press [2 hours on the first day]

    The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 5-10%. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. 1RM will be caculated by the results of 6-RM protocol.

  4. Muscular Fitness Measurements (1RM)-Squat [2 hours on the first day]

    The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 10-20% for. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. 1RM will be caculated by the results of 6-RM protocol.

  5. Muscular Fitness Measurements (1RM)-Rowing [2 hours on the first day]

    The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 5-10%. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. 1RM will be caculated by the results of 6-RM protocol.

  6. Changes In Concentration Of Blood Lactate [2 minutes of each time point (Before the pre-test of cognitive test, after the intervention and before the post-test of cognitive test)]

    Fingertip Blood samples will be collected using Lactate Analyzer in three times point: before the pre-test of cognitive test, after the intervention and before the post-test of cognitive test, and analysed the change in concentration of blood lactate between the three time points.

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years to 26 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • The dominant hand is right-handed

  • 18.5 < BMI < 26

  • Can cooperate with fingertip blood collection

  • No color blindness and epilepsy

  • Not taking medications that affect brain function

  • Irregular exercise (more than 150 minutes per week for 3 months)

Exclusion Criteria:
  • The participants who do not meet the inclusion or The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) Criteria.

Contacts and Locations

Locations

Site City State Country Postal Code
1 National Taiwan Normal University Taipei Taiwan 106

Sponsors and Collaborators

  • National Taiwan Normal University

Investigators

  • Principal Investigator: Yu-Kai Chang, Ph.D., Department of Physical Education and Sport Sciences, National Taiwan Normal University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Yu-Kai Chang, Research Chair professor, National Taiwan Normal University
ClinicalTrials.gov Identifier:
NCT05311202
Other Study ID Numbers:
  • PACNL_202201HM012
First Posted:
Apr 5, 2022
Last Update Posted:
May 13, 2022
Last Verified:
May 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Yu-Kai Chang, Research Chair professor, National Taiwan Normal University

Study Results

No Results Posted as of May 13, 2022