Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?
Study Details
Study Description
Brief Summary
Sprint interval exercise training refers to brief repeated bouts of vigorous effort that are separated by short periods of recovery. Cardiac output refers to the amount of blood that is pumped out of the heart each minute. Research has shown that sprint interval exercise training can increase peak cardiac output - or the highest cardiac output that is achieved during strenuous exercise - but this response may be influenced by biological sex. The primary goal of this study is to determine whether the peak cardiac output response to 12 weeks of sprint interval exercise training differs between males and females. Cardiac output will be estimated using a non-invasive technique that involves breathing in a mixture of standardized gases. This research will help to determine whether biological sex influences the response of the heart to brief vigorous cycle exercise training.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The primary purpose of this study is to determine whether biological sex influences the peak cardiac output response to 12 weeks of sprint interval exercise training. Peak cardiac output will be determined non-invasively using an inert gas rebreathing technique. Each session of sprint interval exercise training will involve a 10-minute period of cycling on a stationary ergometer. The protocol will consist of a two-minute warm-up; three, 20-second 'all out' efforts that are separated by two minutes of recovery; and a three-minute cool down. Three sessions of training will be performed each week for a total of 12 weeks. Groups of male and female participants will be recruited and tested using best practice guidelines for sex-based comparisons of exercise responses. The study will advance knowledge regarding the potential for biological sex to influence the cardiovascular response to brief vigorous cycle exercise training.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Females Female participant group |
Other: Sprint interval exercise training
A 10-minute sprint interval exercise training protocol that is performed three times per week for a total of 12 weeks.
|
| Experimental: Males Male participant group |
Other: Sprint interval exercise training
A 10-minute sprint interval exercise training protocol that is performed three times per week for a total of 12 weeks.
|
Outcome Measures
Primary Outcome Measures
- Peak cardiac output [Change from baseline after 12 weeks of sprint interval exercise training]
Peak cardiac output measured during exercise
Secondary Outcome Measures
- Peak oxygen uptake [Change from baseline after 12 weeks of sprint interval exercise training]
Peak oxygen uptake measured during exercise
- Flow mediated dilation [Change from baseline after 4 and 12 weeks of sprint interval exercise training]
Brachial artery flow mediated dilation
- Pulse wave velocity [Change from baseline after 4 and 12 weeks of sprint interval exercise training]
Central and peripheral pulse wave velocity
Eligibility Criteria
Criteria
Inclusion Criteria:
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Being untrained based on a self-report of engaging in < 1 h of weekly moderate to vigorous physical activity based on the Canadian Society for Exercise Physiology Get Active Questionnaire.
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Having an estimated cardiorespiratory fitness in the lower 50% of adults in the specified age range based on the online fitness calculator available at: www.worldfitnesslevel.org.
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Females who are naturally cycling (i.e., not using any form of hormonal contraceptive) or are using a 2nd generation oral contraceptive.
Exclusion Criteria:
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Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.
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Females with a positive pregnancy test.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | McMaster University | Hamilton | Ontario | Canada | L8S4K1 |
Sponsors and Collaborators
- McMaster University
Investigators
- Principal Investigator: Martin Gibala, PhD, McMaster University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 14279