Exercise Induced Asthma and Airway Reactivity in Athletes

Sponsor

Skane University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT00798564

Collaborator

Swedish Heart Lung Foundation (Other)

300

Enrollment

Duration (Months)

Study Details

Study Description

Brief Summary

The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid related inflammatory response. The investigators also wish to compare indirect testing done as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise challenge.

Condition or Disease	Intervention/Treatment	Phase
Respiratory Function Tests

Detailed Description

By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:

explore the prevalence of positive mannitol reactivity among swimmers and tennis player and how this relates to symptoms, disease history and to a sport specific exercise provocation test.
compare the results from sport specific testing with a standardized eucapnic hyperventilation test (EHV)
compare the overall reactivity to mannitol or EHV among swimmers and tennis players compared to aged matched controls.
explore the role by CC16 in airway reactivity to different provocative stimuli and to see whether there is a difference between different sport activities, different test protocols and between athletes and controls.
explore evidence of eicosanoid related inflammatory reaction in athletes and controls in relation to different provocative stimuli

The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.

Study Design

Study Type:

Observational

Actual Enrollment :

300 participants

Observational Model:

Other

Time Perspective:

Cross-Sectional

Official Title:

Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"

Study Start Date :

Mar 1, 2008

Actual Primary Completion Date :

Jul 1, 2009

Actual Study Completion Date :

Dec 1, 2009

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

16 Years to 25 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Subjects aged 16-19 from Skåne.
All should approve attendance in the study by signing an informed consent. Igf they are aged under 18, parents should also sign.
Three groups are included
Elite aspiring swimmers with an average training intensity of at least hours per week the last year.

Exclusion Criteria:

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Skane University Hospital
Swedish Heart Lung Foundation

Investigators

Principal Investigator: Leif H Bjermer, MD, PhD, Lund University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Leif Bjermer, Professor, MD, Skane University Hospital

ClinicalTrials.gov Identifier:

NCT00798564

Other Study ID Numbers:

34797

First Posted:

Nov 26, 2008

Last Update Posted:

Mar 18, 2021

Last Verified:

Mar 1, 2021

Keywords provided by Leif Bjermer, Professor, MD, Skane University Hospital

Exercise

Mannitol

Additional relevant MeSH terms:

Asthma, Exercise-Induced

Study Results

No Results Posted as of Mar 18, 2021