Clincosm LogoSign in Get a demo

The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

Sponsor
University of British Columbia (Other)
Overall Status
Completed
CT.gov ID
NCT02825823
Collaborator
(none)
10
Enrollment
1
Location
2
Arms
11
Duration (Months)
0.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Ketone Salt
  • Dietary Supplement: Placebo
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
10 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Basic Science
Official Title:
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
Study Start Date :
Jul 1, 2016
Actual Primary Completion Date :
Jun 1, 2017
Actual Study Completion Date :
Jun 1, 2017

Arms and Interventions

Arm Intervention/Treatment
Experimental: Ketone Salts

Acute dose of beta-hydroxybutyrate potassium/sodium salt (0.2g beta-hydroxybutyrate/kg, 0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)

Dietary Supplement: Ketone Salt
Placebo Comparator: Placebo

Acute dose of taste-matched placebo (0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)

Dietary Supplement: Placebo

Outcome Measures

Primary Outcome Measures

  1. Respiratory Exchange Ratio (RER) during cycling exercise [0-18 minutes]

    The RER during 18 minutes of steady-state exercise

Secondary Outcome Measures

  1. 10 km Cycling Time Trial Performance [Following 18 minutes of steady-state exercise]

    10 km time trial performed on a stationary bicycle following 18 minutes of steady-state exercise

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 40 Years
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Males aged 18-40

  • Ability to understand and communicate in English to answer questionnaires and interact with the research assistant

  • Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

Exclusion Criteria:

  • Diagnosed with diabetes or any other medical conditions that could affect metabolism.

  • Diagnosed with heart disease or taking anti-hypertensive medications.

  • Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)

  • Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet

  • Current consumption of ketone supplements

  • Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])

Contacts and Locations

Locations

Site City State Country Postal Code
1 University of British Columbia, Okanagan. Kelowna British Columbia Canada V1V 1V7

Sponsors and Collaborators

  • University of British Columbia

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Jonathan Little, Assistant Professor, University of British Columbia
ClinicalTrials.gov Identifier:
NCT02825823
Other Study ID Numbers:
  • H1601260
First Posted:
Jul 7, 2016
Last Update Posted:
Oct 13, 2017
Last Verified:
Oct 1, 2017

Study Results

No Results Posted as of Oct 13, 2017