Exercise Oxygen Kinetic and Cardiac Output in Hypertrophic Cardiomyopathy
Study Details
Study Description
Brief Summary
Fatigue and dyspnea that reduce exercise performance are common symptoms in patients with hypertrophic cardiomyopathy. Since the cause of this functional limitation has not yet been described, this study aims to evaluate the cardiopulmonary parameters measured at cardiopulmonary exercise test in combination with those obtained by non-invasive measurement of cardiac output by impedance (Physioflow) and echocardiography. These results will help to better define the mechanisms underlying limitation in these patients, also in relation to the degree of LVOT obstruction.
The aim of the present study is to assess the cardiopulmonary response to exercise in patients with hypertrophic cardiomyopathy, based on the degree of LVOT obstruction, by adding non-invasive measurement of cardiac output by Physioflow and echocardiographic parameters to the cardiopulmonary exercise test parameters associated with stroke volume and cardiac output (ie. VO2/WR, O2pulse) Consecutive patients with a previous diagnosis of hypertrophic cardiomyopathy on optimised medical therapy will be enrolled to perform a cardiopulmonary exercise test with simultaneous measurement of cardiac output and an exercise echocardiogram for clinical routine.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- cardiac output measurement [immediately after the evaluation]
Evaluate cardiopulmonary exercise test parameters associated with stroke volume and cardiac output (ie. VO2/WR, O2pulse) with the addition of non-invasive measurement of cardiac output using Physioflow.
Secondary Outcome Measures
- Correlation with echocardiographic variables [immediately after the evaluation]
Correlate functional and metabolic data with echocardiographic variables collected at rest and under stress.
Eligibility Criteria
Criteria
Inclusion Criteria:
- hypertrophic cardiomyopathy diagnosis
Exclusion Criteria:
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use of long-term oxygen therapy;
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presence of comorbidities affecting the ability to perform cardiopulmonary exercise test or interfering with exercise performance;
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concomitant at least moderate chronic obstructive pulmonary disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centro Cardiologico Monzino, Irccs | Milano | Italy | 20138 | |
| 2 | Azienda Ospedaliera Sant'Andrea | Rome | Italy | ||
| 3 | Azienda Sanitaria Universitaria Giuliano Isontina [ASUGI] | Trieste | Italy |
Sponsors and Collaborators
- Centro Cardiologico Monzino
- Azienda Sanitaria Universitaria Giuliano Isontina [ASUGI], Università di Trieste, Italy
- Azienda Ospedaliera "Sant'Andrea"
Investigators
- Principal Investigator: Piergiuseppe Agostoni, Prof., Centro Cardiologico Monzino
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CCM 1750