Effects of a Caffeine- and Protein-Containing Coffee Beverage on Metabolism and Muscular Performance

Sponsor
Texas Tech University (Other)
Overall Status
Completed
CT.gov ID
NCT04180787
Collaborator
Vital Pharmaceuticals, Inc. (Other)
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Study Details

Study Description

Brief Summary

The purpose of this randomized, double-blind, crossover study is to investigate the effects of Bang® Keto Coffee on resting and post-exercise metabolism and muscular performance during lower body resistance exercise.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Beverage Consumption
N/A

Detailed Description

Resistance-trained males and females will be recruited for participation in a randomized, double-bind, crossover trial. After providing informed consent, each participant will undergo a familiarization session to become accustomed to the study procedures. Following familiarization, each participant will complete two laboratory visits consisting of metabolism and exercise performance assessments. In both visits, a baseline assessment of resting metabolic rate (RMR) and respiratory exchange ratio (RER) will be conducted using indirect calorimetry. Following the initial RMR assessment, each participant will ingest a coffee flavored beverage, either VPX Bang® Keto Coffee or a flavor-matched placebo. After beverage consumption, the participant will return to the supine position and rest prior to initiation of the second RMR assessment. Immediately following the second RMR assessment, the participant will begin a 5-minute dynamic bodyweight warm up. Participants will then begin squat testing procedures on a mechanized squat device. After completing the squat testing, participants will complete a standard 1-repetition maximum and repetitions to failure using a plate-loaded hip sled machine. Following the hip sled testing, participants will repeat the mechanized squat testing. Following completion of the exercise testing, a third and final RMR assessment will be performed. Following successful completion of the first condition, each participant will enter a wash out period, after which the visit will be repeated with ingestion of the alternative beverage.

Study Design

Study Type:
Interventional
Actual Enrollment :
19 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose:
Other
Official Title:
Effects of a Caffeine- and Protein-Containing Coffee Beverage on Metabolism and Muscular Performance
Actual Study Start Date :
Dec 5, 2019
Actual Primary Completion Date :
Mar 9, 2020
Actual Study Completion Date :
Mar 9, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: Keto Coffee

VPX Bang® Keto Coffee beverage

Dietary Supplement: Beverage Consumption
Participants will consume either VPX Bang® Keto Coffee beverage or flavor-matched placebo beverage in each condition.

Placebo Comparator: Placebo

Flavor-matched placebo beverage

Dietary Supplement: Beverage Consumption
Participants will consume either VPX Bang® Keto Coffee beverage or flavor-matched placebo beverage in each condition.

Outcome Measures

Primary Outcome Measures

  1. Isometric Force Production [Assessed approximately 45 minutes after beverage ingestion]

    Isometric force production on mechanized squat device

  2. Isometric Force Production [Assessed approximately 80 minutes after beverage ingestion]

    Isometric force production on mechanized squat device

  3. Isokinetic Force Production [Assessed approximately 45 minutes after beverage ingestion]

    Isokinetic force production on mechanized squat device

  4. Isokinetic Force Production [Assessed approximately 80 minutes after beverage ingestion]

    Isokinetic force production on mechanized squat device.

  5. Maximal Lower Body Strength [Assessed approximately 75 minutes after beverage ingestion]

    One-repetition maximum on hip sled machine

  6. Maximal Lower Body Endurance [Assessed approximately 75 minutes after beverage ingestion (following maximal lower body strength testing)]

    Repetitions to failure on hip sled machine

  7. Change in Metabolic Rate [Change in metabolic rate between: 1) before beverage ingestion (baseline) and 2) beginning approximately 10 minutes after completion of beverage ingestion]

    Metabolic rate assessed via indirect calorimetry

  8. Change in Metabolic Rate [Change in metabolic rate between: 1) before beverage ingestion (baseline) and 2) beginning approximately 5 minutes after completion of all exercise testing]

    Metabolic rate assessed via indirect calorimetry

  9. Change in Respiratory Exchange Ratio [Change in respiratory exchange ratio between: 1) before beverage ingestion (baseline) and 2) beginning approximately 10 minutes after completion of beverage ingestion]

    Respiratory exchange ratio as assessed via indirect calorimetry

  10. Change in Respiratory Exchange Ratio [Change in respiratory exchange ratio between: 1) before beverage ingestion (baseline) and 2) beginning approximately 5 minutes after completion of all exercise testing.]

    Respiratory exchange ratio as assessed via indirect calorimetry

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 40 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Between the ages of 18 and 40

  • Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplement of performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).

  • Resistance-trained, defined as completing 3+ resistance training sessions per week for at least one year and including at least weekly training of the lower body through a multi-joint exercise such as the squat or leg press.

  • Regular caffeine consumption, defined as an average self-reported daily intake of 200+ mg of caffeine, which is equivalent to approximately 2 cups of coffee.

Exclusion Criteria:
  • Failing to meet any of the aforementioned inclusion criteria.

  • Pregnant or breastfeeding (for female participants)

  • Taking prescription medication which could reasonably make participation unsafe for the participant or influence study outcomes

  • An inability to complete lower body resistance exercise due to injury or medical condition

  • Self-reported caffeine sensitivity, as indicated by unwanted side effects when caffeine is consumed.

  • Allergy to any of the ingredients in the commercially available dietary supplement

  • Self-reported claustrophobia (due to metabolism testing)

Contacts and Locations

Locations

Site City State Country Postal Code
1 Department of Kinesiology & Sport Management Lubbock Texas United States 79409

Sponsors and Collaborators

  • Texas Tech University
  • Vital Pharmaceuticals, Inc.

Investigators

  • Principal Investigator: Grant M Tinsley, PhD, Texas Tech University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Texas Tech University
ClinicalTrials.gov Identifier:
NCT04180787
Other Study ID Numbers:
  • 20-0130
First Posted:
Nov 29, 2019
Last Update Posted:
May 7, 2020
Last Verified:
May 1, 2020
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of May 7, 2020