The Patients' Experience After Stem Cell Transplant
Study Details
Study Description
Brief Summary
In this study, the investigators are looking to understand: 1) how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; 2) whether these changes affect day-to-day activities and quality of life; and 3) how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Participants will undergo neurocognitive testing along with the collection of a saliva sample and completing a battery of questionnaires and assessments.
Study Design
Outcome Measures
Primary Outcome Measures
- Assess differences with cognitive function in older patients undergoing allogeneic or autologous stem cell transplant at 4 timepoints. [Before transplant; Post Transplant at 100 days, 6 months, and 12 months]
Cognition will be measured using a neuropsychological battery.
Secondary Outcome Measures
- Assess quality of life of of older patients undergoing allogeneic and autologous transplant at 4 timepoints. [Before transplant; Post Transplant at 100 days, 6 months, and 12 months]
Quality of life will be measured with the EORTC Quality of Life-30C questionnaire.
- Assess activity engagement of older patients undergoing allogeneic and autologous transplant at 4 timepoints. [Before transplant; Post Transplant at 100 days, 6 months, and 12 months]
Activity engagement will be measured with the Activity Card Sort-modified.
- Describe genetic variations in genes potentially involved in cognitive function and cancer treatment. [1 time collection: Before transplant]
A saliva sample will be collected to look at genetic variations.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Between the ages of 60-85
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Diagnosed with a hematological malignancy
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Is considering an autologous or allogeneic stem cell transplant OR has undergone stem cell transplant in the past 12 months and seen by the PI for pre-transplant evaluation.
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Is able to read, write, speak, and understand English
Exclusion Criteria:
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As per self report or medical record, history of central nervous system involvement and/or history of cranial irradiation or intrathecal chemotherapy except for patients with history of prophylactic intrathecal chemotherapy.
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As per self report or medical record, history of stroke, head injury, neurosurgery, seizure disorder, or demyelinating disorder.
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As per self report or medical record, history of substance use disorder.
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As per self report or in the judgement of the consenting professional, uncorrected vision loss.
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As per self report or medical record, primary psychiatric disorder necessitating inpatient treatment in the last 12 months.
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As per self report or medical record, history of allogeneic and or autologous stem cell transplant.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
Sponsors and Collaborators
- University of Nebraska
Investigators
- Principal Investigator: Thuy Koll, MD, University of Nebraska
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 431-17-EP