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Explanted Lung Tissues With Pulmonary Fibrosis

Sponsor
University of Chicago (Other)
Overall Status
Unknown status
CT.gov ID
NCT00515567
Collaborator
(none)
90
Enrollment
1
Location
190
Duration (Months)
0.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of this study is to use the tissues from the explanted lungs in order to better study the cause of pulmonary fibrosis at a cellular level.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. The most current thinking is that the fibrotic process is a reaction to tiny injury to the lung. When the scar forms, the tissue becomes thicker causing a permanent loss of the tissue's ability to carry oxygen into the bloodstream.

    We need to obtain lung tissue from patients without pulmonary fibrosis and compare it to lung tissue from patients with pulmonary fibrosis.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    90 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Utilization of Explanted Lungs for Isolation of Tissue Samples and Primary Cell Lines to Study Pulmonary Fibrosis
    Study Start Date :
    Feb 1, 2006
    Anticipated Primary Completion Date :
    Dec 1, 2020
    Anticipated Study Completion Date :
    Dec 1, 2021

    Outcome Measures

    Primary Outcome Measures

    1. assess fibroblasts and cytokines associated with pulmonary fibrosis [12/2013]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • all patients awaiting lung transplant
    Exclusion Criteria:
    • all who will not give consent

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 The University of Chicago Chicago Illinois United States 60637

    Sponsors and Collaborators

    • University of Chicago

    Investigators

    • Principal Investigator: Robert Guzy, MD, University of Chicago

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    University of Chicago
    ClinicalTrials.gov Identifier:
    NCT00515567
    Other Study ID Numbers:
    • 14514A
    First Posted:
    Aug 13, 2007
    Last Update Posted:
    Apr 2, 2020
    Last Verified:
    Apr 1, 2020
    Keywords provided by University of Chicago
    explanted lungs
    pulmonary fibrosis
    Additional relevant MeSH terms:
    Pulmonary Fibrosis
    Fibrosis

    Study Results

    No Results Posted as of Apr 2, 2020