VOCs: Exploratory Study of Volatile Organic Compounds in Alveolar Breath
Study Details
Study Description
Brief Summary
The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Individuals with metabolic disorders may sporadically produce malodors despite good hygiene. Analysis of volatile organic compounds (VOCs) helps to gain insights into medical conditions arising due to metabolic dysfunction as different metabolic pathways emit and or consume various VOCs. These VOCs can be detected via the exhaled breath collected and analyzed with a portable breath collection apparatus. VOC profiles will be compared with self-reported symptoms and other observations of participating subjects.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Body odor individuals self-reporting idiopathic body odor with or without bad breath |
Other: Breath test
Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.
Other Names:
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Breath odor individuals self-reporting idiopathic bad breath but no body odor |
Other: Breath test
Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.
Other Names:
|
Outcome Measures
Primary Outcome Measures
- VOCs detected [2 years]
Expired air sample drawn principally from alveolar breath is analyzed by gas chromatography-mass spectrometry. Chromatograms are searched against the NIST library. The response for each analyte is normalized by using internal standards containing 1-bromo-4-fluoro-benzene.
Secondary Outcome Measures
- Correlations between breath biomarkers and self-reported observations (questionnaires) [1 year]
VOC profiles will be compared with self-reported symptoms, observed exposures and other observations of participating subjects. Volatile organic compounds differentiating the disease activity will be identified.
Eligibility Criteria
Criteria
Inclusion Criteria:
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good general health
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willing and able to travel to one of the participating sites
Exclusion Criteria:
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medical conditions that, in the opinion of the investigator, would prevent participation
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elect not to participate in the study
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | MeBO Research | Miami | Florida | United States | 33175 |
2 | MeBO Research LTD | London | England | United Kingdom | W10 5LE |
Sponsors and Collaborators
- Mebo Research, Inc.
- Menssana Research, Inc.
- Aurametrix
Investigators
- Principal Investigator: Irene Gabashvili, PhD, MeBO Research
Study Documents (Full-Text)
None provided.More Information
Publications
- 20111001005MEBO