Exploring of Serum Biomarkers of Delirium After Cardiovascular Surgery
Study Details
Study Description
Brief Summary
The incidence of postoperative delirium in patients after cardiovascular surgery is very high, which seriously affects the short-term and long-term prognosis of patients, but its mechanism is not clear. Recent studies have found that lactic acid participates in the process of sepsis by inducing histone lactatation in macrophages. histone H3 lysine 18 lactylation (H3K18la) is significantly associated with the severity of disease and inflammatory response. Inflammation plays an important role in postoperative delirium. We therefore hypothesized that macrophage H3K18la also plays a role in postoperative delirium.At the same time, the latest literature shows that the early markers of Alzheimer's disease (AD), such as exosomes and phosphorylated tau396, 404, etc. [5], can also be detected in the serum of AD patients. Given the obvious correlation between Alzheimer's disease and postoperative delirium [6], we hypothesized that serum phosphorylated exosome and phosphorylated tau396,404 could also be used as serum biomarkers for postoperative delirium.
The objectives of this study were to investigate the correlation between H3K18 in serum monocytes and postoperative delirium and its severity in patients undergoing cardiovascular surgery under cardiopulmonary bypass. Meanwhile, we also detect the serum levels of exosome and phosphorylated tau396,404 in patients undergoing major cardiac surgery. We aim to find the serum biomarkers of delirium after major cardiac surgery, so as to provide a more convenient diagnostic basis for the prevention of postoperative delirium.
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Study Design
Outcome Measures
Primary Outcome Measures
- Association of H3K18 with postoperative delirium and its severity in patients undergoing cardiovascular surgery under cardiopulmonary bypass [Perioperative data]
Eligibility Criteria
Criteria
Inclusion Criteria:
patients who receive elective cardiovascular surgery under cardiopulmonary bypass
- Patients participated voluntarily and signed informed consent
Exclusion Criteria:
- past medical history of neurological and psychiatric diseases; severe visual or hearing impairment;
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Huazhong University of Science and Technology
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- TJMZK202301