Expression of Steroid Receptors in Endometrium

Sponsor

Aristotle University Of Thessaloniki (Other)

Overall Status

Completed

CT.gov ID

NCT00436462

Collaborator

(none)

Enrollment

Location

Duration (Months)

1.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Expression of steroid receptors in endometrium during ovarian stimulation.

Condition or Disease	Intervention/Treatment	Phase
Endometrium

Detailed Description

The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.

Study Design

Study Type:

Observational

Anticipated Enrollment :

30 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Expression of Steroid Receptors in Endometrium During the Early Follicular Phase in Stimulated Cycles

Study Start Date :

Dec 1, 2005

Actual Primary Completion Date :

Dec 1, 2007

Actual Study Completion Date :

Dec 1, 2007

Outcome Measures

Primary Outcome Measures

Steroid receptors expression in endometrium during early follicular phase [3 months]

Secondary Outcome Measures

In which day:day o+2, day 0+4 or day HCG [1 month]

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 39 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Inclusion Criteria:

Treatment by IUI,
BMI:18-29KGR/M2,
No previous ovarian surgery,
Normal hysterosalpingography,
Estradiol < 80pg/ml and progesterone < 1.6ng/ml on day 2 of the cycle

Exclusion Criteria:

Endometriosis,
Severe male factor

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital	Thessaloniki		Greece	56429

Sponsors and Collaborators

Aristotle University Of Thessaloniki

Investigators

Study Director: Basil C Tarlatzis, MD,PhD, Unit of Human Reproduction, 1st Department of Obst & Gyn, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece