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The Expression of TLR2 and TLR4 in the Lung of Chronic Obstructive Pulmonary Disease (COPD) Patients

Sponsor
Seoul National University Bundang Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT01226199
Collaborator
(none)
60
Enrollment
1
Location
17
Duration (Months)
3.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Smoking is the most important risk factor of COPD, but only a fourth of smokers had COPD in their life. There are also healthy smokers without evidence of COPD. Investigators hypothesize that innate immunity may affect this difference between COPD patients and healthy smokers, because TLR4 is the receptor of LPS, which is the one of important substance in cigarette. Investigators will measure TLR2 and TLR4 expression in lung tissue of patients whose lung will be resected. Investigators will compare the level of expression between COPD patients and healthy smokers.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    60 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    The Expression of TLR2 and TLR4 in the Lung of COPD Patients
    Study Start Date :
    Oct 1, 2010
    Anticipated Primary Completion Date :
    Dec 1, 2011
    Anticipated Study Completion Date :
    Mar 1, 2012

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • All patients who will have lung resection for the therapeutic cause.
      Exclusion Criteria:
      • Patients who do not agree with our study protocol

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Seoul National University Bundang Hospital Seongnam Gyeongi Korea, Republic of 482 060

      Sponsors and Collaborators

      • Seoul National University Bundang Hospital

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT01226199
      Other Study ID Numbers:
      • TLR2 and TLR4 in COPD tissue
      First Posted:
      Oct 22, 2010
      Last Update Posted:
      Jun 8, 2011
      Last Verified:
      Jun 1, 2011

      Study Results

      No Results Posted as of Jun 8, 2011