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Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT04334941
Collaborator
(none)
94
Enrollment
564
Locations
2
Arms
65.5
Anticipated Duration (Months)
0.2
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase II trial studies whether atezolizumab in combination with talazoparib works better than atezolizumab alone as maintenance therapy for patients with SLFN11-positive extensive-stage small cell lung cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. PARPs are proteins that help repair damage to DNA, the genetic material that serves as the body's instruction book. Changes (mutations) in DNA can cause tumor cells to grow quickly and out of control, but PARP inhibitors like talazoparib may keep PARP from working, so tumor cells can't repair themselves, and they stop growing. Giving atezolizumab in combination with talazoparib may help lower the chance of extensive-stage small cell lung cancer growing and spreading compared to atezolizumab alone.

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare progression free survival (PFS) among participants with Schlafen family member 11 (SLFN11) positive extensive stage small cell lung cancer (ES-SCLC) randomized to atezolizumab or atezolizumab plus talazoparib as maintenance therapy.
SECONDARY OBJECTIVES:

  1. To compare overall survival (OS) between the arms. II. To compare objective response rate (ORR) among participants with measurable disease between the arms, including complete response (CR) and partial response (PR) (confirmed and unconfirmed) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

  2. To evaluate the frequency and severity of adverse events within each treatment arm.

TRANSLATIONAL MEDICINE OBJECTIVE:
  1. To bank specimens for future correlative studies.

OUTLINE: Patients are screened for SLFN11 biomarker during Step 1: Screening Registration by submitting tumor tissue to MDACC. Patients with SLFN11 biomarker are registered to Step 2: Randomization and are randomized to 1 or 2 arms.

ARM I: Patients receive atezolizumab intravenously (IV) over 30-60 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive atezolizumab IV over 30-60 minutes on day 1 and talazoparib orally (PO) once daily (QD) on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 6 months for 2 years and at the end of 3 years from randomization.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
94 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Phase II Randomized Study of Maintenance Atezolizumab Versus Atezolizumab in Combination With Talazoparib in Patients With SLFN11 Positive Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Actual Study Start Date :
Jun 15, 2020
Anticipated Primary Completion Date :
Nov 30, 2025
Anticipated Study Completion Date :
Nov 30, 2025

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Arm I (atezolizumab)

Patients receive atezolizumab IV over 30-60 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Drug: Atezolizumab
Given IV
Other Names:
  • MPDL 3280A
  • MPDL 328OA
  • MPDL-3280A
  • MPDL3280A
  • MPDL328OA
  • RG7446
  • RO5541267
  • Tecentriq

    		•
    Experimental: Arm II (atezolizumab, talazoparib)

    Patients receive atezolizumab IV over 30-60 minutes on day 1 and talazoparib PO QD on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

    Drug: Atezolizumab
    Given IV
    Other Names:
  • MPDL 3280A
  • MPDL 328OA
  • MPDL-3280A
  • MPDL3280A
  • MPDL328OA
  • RG7446
  • RO5541267
  • Tecentriq

    • Drug: Talazoparib
    Given PO
    Other Names:
  • BMN 673
  • BMN-673

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Progression free survival [From the date of maintenance randomization to the date of first document of progression or symptomatic deterioration, or death due to any cause, assessed up to 18 months]

      Analysis will be done using a 1-sided 10% level stratified log-rank test. Will be estimated using the Kaplan-Meier method. Associated confidence intervals around the median will be performed using the Brookmeyer-Crowley method.

    Secondary Outcome Measures

    1. Overall survival [From the date of maintenance randomization until death from any cause, with participants last known to be alive censored at the date of last contact, assessed up to 3 years from randomization]

      Will be estimated using the Kaplan-Meier method. Associated confidence intervals around the median will be performed using the Brookmeyer-Crowley method.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • STEP 1: SCREENING REGISTRATION: Participants must have histologically or pathologically confirmed diagnosis of extensive stage small cell lung cancer (ES-SCLC) at the time of protocol entry. Participants who have transformed to SCLC from lung non-small cell carcinoma (NSCLC) or have SCLC with mixed histology are not eligible

    • STEP 1: SCREENING REGISTRATION: Participants must have completed at least day 3 of cycle 1 dosing of frontline induction treatment with platinum plus etoposide plus atezolizumab prior to Step 1 Screening Registration. Cycle 1 of frontline induction treatment may or may not contain atezolizumab

    • NOTE: Participants may be screened while receiving consolidation thoracic radiation or during prophylactic cranial irradiation (PCI) at the time of Step 1 Screening Registration. Participants may or may not receive consolidation thoracic radiation and/or PCI per the discretion of their treating investigator

    • STEP 1: SCREENING REGISTRATION: Participants must not have received any immunotherapy for SCLC prior to starting the frontline induction treatment for ES-SCLC

    • STEP 1: SCREENING REGISTRATION: Participants must not have received any investigational agent for the treatment of ES-SCLC

    • STEP 1: SCREENING REGISTRATION: Participants must have adequate tumor tissue available from a core biopsy or fine needle aspiration (FNA) defined as:

    • At least two (3-5 microns) (three slides preferred) unstained slides, or;

    • One (3-5 microns) (two slides preferred) unstained slide plus one H&E stained slide

    • Participants must agree to have this tissue submitted to M.D. Anderson Cancer Center (MDACC) for SLFN11 immunohistochemistry (IHC) testing. Note: A histologic review will be performed at MDACC to confirm adequate cellularity for the testing. If inadequate cellularity, additional unstained slides from the same participant may be submitted if it doesn't exceed the window of starting maintenance therapy

    • STEP 1: SCREENING REGISTRATION: Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines

    • STEP 1: SCREENING REGISTRATION: As a part of the Oncology Participant Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    • STEP 1: SCREENING REGISTRATION: Participants with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator)

    • STEP 2: RANDOMIZATION: Site must have received notification from the SWOG Statistics and Data Management Center (SDMC) that the participant's tumor sample is SLFN11 positive

    • STEP 2: RANDOMIZATION: Participants must have their disease assessed either by computed tomography (CT) of chest/abdomen/pelvis (with contrast, unless contraindicated) within 28 days prior to Step 2 Registration for measurable disease or by positron emission tomography (PET)PET/CT of chest/abdomen/pelvis (with contrast, unless contraindicated) within 42 days prior to Step 2 Registration for non-measurable disease. Participants may have a complete response to induction therapy. All known sites of disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1). Study participants will not be considered eligible if a non-diagnostic PET/CT of chest/abdomen/pelvis is used to assess measurable disease prior to Step 2 Registration

    • STEP 2: RANDOMIZATION: Patients must have a CT or magnetic resonance imaging (MRI) scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to Step 2 randomization. Patient must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment, and prior to Step 2 randomization, AND (2) participant has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to Step 2 randomization

    • STEP 2: RANDOMIZATION: Participants must not have had disease progression based on post induction imaging in the opinion of treating investigator

    • STEP 2: RANDOMIZATION: Participants must be registered to Step 2 Randomization prior to the start of maintenance atezolizumab

    • STEP 2: RANDOMIZATION: Participants must have received no fewer than 2 cycles and no more than 4 cycles of induction treatment with platinum/etoposide/atezolizumab

    • STEP 2: RANDOMIZATION: Participant must not have received radiation treatment (RT) or prophylactic cranial irradiation (PCI) within 14 days prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants must not be taking strong P-glycoprotein (P-gp) inhibitors (e.g., dronedarone, quinidine, ranolazine), P-gp inducers (e.g., rifampin), or breast cancer resistance protein (BCRP) inhibitors (e.g., elacridar) within 7 days prior to randomization. Participants must not plan to receive the therapies listed above while on protocol treatment)

    • STEP 2: RANDOMIZATION: Participants must not have experienced the following during induction treatment:

    • Any grade 3 or worse immune-related adverse event (irAE) in the opinion of the treating investigator. Exception: asymptomatic nonbullous/nonexfoliative rash

    • Any unresolved grade 2 irAE

    • Any toxicity that led to permanent discontinuation of prior anti-PD-1/PD-L1 immunotherapy. Exception to the above: Toxicities of any grade that require replacement therapy and have stabilized on therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) are allowed

    • STEP 2: RANDOMIZATION: History and physical exam must be obtained within 28 days prior to Step 2 randomization

    • STEP 2: RANDOMIZATION: Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function and be considered class 2B or better on the New York Heart Association Functional Classification

    • STEP 2: RANDOMIZATION: Participants must have Zubrod performance status 0-2 documented within 28 days prior to Step 2 Randomization.

    • STEP 2: RANDOMIZATION: Leukocytes >= 3 x 10^3/mL (within 28 days prior to Step 2 Randomization)

    • STEP 2: RANDOMIZATION: Absolute neutrophil count >= 1.5 x 10^3/mL (within 28 days prior to Step 2 Randomization)

    • STEP 2: RANDOMIZATION: Platelets >= 100 x 10^3/mL (within 28 days prior to Step 2 Randomization)

    • STEP 2: RANDOMIZATION: Total bilirubin =< institutional upper limit of normal (ULN) (within 28 days prior to Step 2 Randomization)

    • STEP 2: RANDOMIZATION: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x institutional ULN (within 28 days prior to Step 2 Randomization)

    • STEP 2: RANDOMIZATION: Creatinine =< institutional ULN OR estimated creatinine clearance > 30 mL/min (within 28 days prior to Step 2 Randomization)

    • STEP 2: RANDOMIZATION: Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within in 6 months prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment must have an undetectable HCV viral load within in 6 months prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants with known human immunodeficiency virus (HIV) infection must be on effective anti-retroviral therapy and must have undetectable viral load at their most recent viral load test and within 6 months prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants must be able to swallow capsule whole

    • STEP 2: RANDOMIZATION: Participants with known diabetes must not have uncontrolled diabetes. (Uncontrolled diabetes is defined as glycosylated hemoglobin [HgA1C] > 7%)

    • STEP 2: RANDOMIZATION: Participants must not have any known clinically significant liver disease, including cirrhosis, fatty liver, or inherited liver disease

    • STEP 2: RANDOMIZATION: Participants must not have end stage renal or other serious medical illness that may limit survival or the ability to participate in this study

    • STEP 2: RANDOMIZATION: Participants must not have a history of idiopathic pulmonary fibrosis, pneumonitis (including drug induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on screening chest computed tomography (CT) scan. History of radiation pneumonitis in the radiation field (fibrosis) is permitted

    • STEP 2: RANDOMIZATION: Participants must not have known active tuberculosis (TB)

    • STEP 2: RANDOMIZATION: Participants must not have undergone prior allogeneic bone marrow transplantation or prior solid organ transplantation

    • STEP 2: RANDOMIZATION: Participants must not have history of allergic reaction attributed to compounds of similar chemical or biological composition to atezolizumab and/or talazoparib

    • STEP 2: RANDOMIZATION: Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen

    • STEP 2: RANDOMIZATION: Participants must not be on corticosteroids at doses greater than prednisone 10 mg daily or equivalent within 7 days prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants must not receive any live attenuated vaccines within 28 days prior to Step 2 Randomization or at any time during the study and until 5 months after the last dose of protocol treatment

    • STEP 2: RANDOMIZATION: Participants must not have severe infections in the form of severe sepsis or septic shock including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia within 14 days prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants must not be pregnant due to the potential teratogenic side effects of the protocol treatment. Women of reproductive potential and men must have agreed to use an effective contraception method for the duration of protocol treatment, and for 7 months after the last dose of protocol treatment. A woman is considered to be of "reproductive potential" if she has had a menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with atezolizumab, breastfeeding must be discontinued prior to Step 2 Randomization

    • STEP 2: RANDOMIZATION: Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the SWOG Specimen Tracking System

    • STEP 2: RANDOMIZATION: Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines

    • STEP 2: RANDOMIZATION: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    • STEP 2: RANDOMIZATION: Participants with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator)

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Kingman Regional Medical Center Kingman Arizona United States 86401
    10 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    11 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    12 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    13 NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro Arkansas United States 72401
    14 University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
    15 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    16 PCR Oncology Arroyo Grande California United States 93420
    17 Tower Cancer Research Foundation Beverly Hills California United States 90211
    18 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    19 21st Century Oncology - El Segundo El Segundo California United States 90245
    20 Loma Linda University Medical Center Loma Linda California United States 92354
    21 Cedars Sinai Medical Center Los Angeles California United States 90048
    22 Fremont - Rideout Cancer Center Marysville California United States 95901
    23 Providence Queen of The Valley Napa California United States 94558
    24 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    25 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    26 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    27 Providence Medical Foundation - Santa Rosa Santa Rosa California United States 95403
    28 Providence Santa Rosa Memorial Hospital Santa Rosa California United States 95405
    29 Cedars-Sinai Cancer - Tarzana Tarzana California United States 91356
    30 Torrance Memorial Physician Network - Cancer Care Torrance California United States 90505
    31 Torrance Memorial Medical Center Torrance California United States 90509
    32 Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee California United States 96161
    33 University of Colorado Hospital Aurora Colorado United States 80045
    34 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    35 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    36 UCHealth Memorial Hospital Central Colorado Springs Colorado United States 80909
    37 Memorial Hospital North Colorado Springs Colorado United States 80920
    38 Saint Francis Cancer Center Colorado Springs Colorado United States 80923
    39 Porter Adventist Hospital Denver Colorado United States 80210
    40 Mercy Medical Center Durango Colorado United States 81301
    41 Southwest Oncology PC Durango Colorado United States 81301
    42 Poudre Valley Hospital Fort Collins Colorado United States 80524
    43 Cancer Care and Hematology-Fort Collins Fort Collins Colorado United States 80528
    44 Grand Valley Oncology Grand Junction Colorado United States 81505
    45 UCHealth Greeley Hospital Greeley Colorado United States 80631
    46 Saint Anthony Hospital Lakewood Colorado United States 80228
    47 Littleton Adventist Hospital Littleton Colorado United States 80122
    48 UCHealth Lone Tree Health Center Lone Tree Colorado United States 80124
    49 Longmont United Hospital Longmont Colorado United States 80501
    50 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    51 Medical Center of the Rockies Loveland Colorado United States 80538
    52 Parker Adventist Hospital Parker Colorado United States 80138
    53 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    54 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    55 Beebe Medical Center Lewes Delaware United States 19958
    56 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    57 Helen F Graham Cancer Center Newark Delaware United States 19713
    58 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    59 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    60 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    61 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    62 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    63 GenesisCare USA - Aventura FP Aventura Florida United States 33180
    64 GenesisCare USA - Aventura Aventura Florida United States 33180
    65 Mount Sinai Comprehensive Cancer Center at Aventura Aventura Florida United States 33180
    66 GenesisCare USA - Boca Raton FP02 Boca Raton Florida United States 33428
    67 GenesisCare USA - Boca Ration FP06 Boca Raton Florida United States 33431
    68 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    69 GenesisCare USA - Key West Key West Florida United States 33040
    70 GenesisCare USA - Lakewood Ranch Lakewood Ranch Florida United States 34202
    71 Mount Sinai Medical Center Miami Beach Florida United States 33140
    72 GenesisCare USA - Palm Beach Gardens Palm Beach Gardens Florida United States 33410
    73 GenesisCare USA - Plantation Plantation Florida United States 33324
    74 Good Samaritan Medical Center West Palm Beach Florida United States 33401
    75 Augusta University Medical Center Augusta Georgia United States 30912
    76 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    77 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    78 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    79 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    80 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    81 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    82 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    83 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    84 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    85 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    86 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    87 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    88 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    89 Saint Anthony's Health Alton Illinois United States 62002
    90 Rush - Copley Medical Center Aurora Illinois United States 60504
    91 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    92 Loyola Center for Health at Burr Ridge Burr Ridge Illinois United States 60527
    93 Illinois CancerCare-Canton Canton Illinois United States 61520
    94 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    95 SIH Cancer Institute Carterville Illinois United States 62918
    96 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    97 Centralia Oncology Clinic Centralia Illinois United States 62801
    98 Northwestern University Chicago Illinois United States 60611
    99 Jesse Brown Veterans Affairs Medical Center Chicago Illinois United States 60612
    100 University of Illinois Chicago Illinois United States 60612
    101 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    102 Carle on Vermilion Danville Illinois United States 61832
    103 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    104 Decatur Memorial Hospital Decatur Illinois United States 62526
    105 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    106 Carle Physician Group-Effingham Effingham Illinois United States 62401
    107 Crossroads Cancer Center Effingham Illinois United States 62401
    108 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    109 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    110 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    111 Ingalls Memorial Hospital Harvey Illinois United States 60426
    112 Loyola Medicine Homer Glen Homer Glen Illinois United States 60491
    113 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    114 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    115 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    116 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    117 Loyola University Medical Center Maywood Illinois United States 60153
    118 Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park Illinois United States 60160
    119 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    120 UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois United States 60451
    121 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    122 University of Chicago Medicine-Orland Park Orland Park Illinois United States 60462
    123 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    124 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    125 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    126 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    127 Illinois CancerCare-Peru Peru Illinois United States 61354
    128 Valley Radiation Oncology Peru Illinois United States 61354
    129 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    130 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    131 Springfield Clinic Springfield Illinois United States 62702
    132 Memorial Medical Center Springfield Illinois United States 62781
    133 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    134 Carle Cancer Center Urbana Illinois United States 61801
    135 The Carle Foundation Hospital Urbana Illinois United States 61801
    136 Illinois CancerCare - Washington Washington Illinois United States 61571
    137 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    138 Reid Health Richmond Indiana United States 47374
    139 Mary Greeley Medical Center Ames Iowa United States 50010
    140 McFarland Clinic PC - Ames Ames Iowa United States 50010
    141 McFarland Clinic PC-Boone Boone Iowa United States 50036
    142 Saint Anthony Regional Hospital Carroll Iowa United States 51401
    143 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    144 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    145 Jennie Edmundson Memorial Hospital Council Bluffs Iowa United States 51502
    146 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    147 Heartland Oncology and Hematology LLP Council Bluffs Iowa United States 51503
    148 Greater Regional Medical Center Creston Iowa United States 50801
    149 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    150 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    151 Broadlawns Medical Center Des Moines Iowa United States 50314
    152 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    153 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    154 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    155 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    156 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    157 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    158 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    159 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    160 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    161 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    162 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    163 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    164 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    165 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    166 Saint Joseph Hospital East Lexington Kentucky United States 40509
    167 Saint Joseph London London Kentucky United States 40741
    168 Jewish Hospital Louisville Kentucky United States 40202
    169 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    170 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    171 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    172 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    173 Our Lady of The Lake Baton Rouge Louisiana United States 70808
    174 Louisiana Hematology Oncology Associates LLC Baton Rouge Louisiana United States 70809
    175 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    176 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    177 Northshore Oncology Associates-Covington Covington Louisiana United States 70433
    178 Terrebonne General Medical Center Houma Louisiana United States 70360
    179 Ochsner LSU Health Monroe Medical Center Monroe Louisiana United States 71202
    180 LSU Health Sciences Center at Shreveport Shreveport Louisiana United States 71103
    181 Greater Baltimore Medical Center Baltimore Maryland United States 21204
    182 Beverly Hospital Beverly Massachusetts United States 01915
    183 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    184 Addison Gilbert Hospital Gloucester Massachusetts United States 01930
    185 Lahey Medical Center-Peabody Peabody Massachusetts United States 01960
    186 Winchester Hospital Winchester Massachusetts United States 01890
    187 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    188 Bronson Battle Creek Battle Creek Michigan United States 49017
    189 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    190 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    191 Henry Ford Cancer Institute-Downriver Brownstown Michigan United States 48183
    192 Saint Joseph Mercy Canton Canton Michigan United States 48188
    193 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    194 Caro Cancer Center Caro Michigan United States 48723
    195 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    196 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    197 GenesisCare USA - Clarkston Clarkston Michigan United States 48346
    198 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    199 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    200 Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan United States 48038
    201 Henry Ford Medical Center-Fairlane Dearborn Michigan United States 48126
    202 Henry Ford Hospital Detroit Michigan United States 48202
    203 Ascension Saint John Hospital Detroit Michigan United States 48236
    204 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    205 GenesisCare USA - Farmington Hills Farmington Hills Michigan United States 48334
    206 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    207 Genesee Hematology Oncology PC Flint Michigan United States 48503
    208 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    209 Hurley Medical Center Flint Michigan United States 48503
    210 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    211 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    212 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    213 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    214 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    215 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    216 Allegiance Health Jackson Michigan United States 49201
    217 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    218 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    219 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    220 Borgess Medical Center Kalamazoo Michigan United States 49048
    221 Sparrow Hospital Lansing Michigan United States 48912
    222 Hope Cancer Clinic Livonia Michigan United States 48154
    223 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    224 GenesisCare USA - Macomb Macomb Michigan United States 48044
    225 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    226 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    227 GenesisCare USA - Madison Heights Madison Heights Michigan United States 48071
    228 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    229 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    230 Lakeland Hospital Niles Niles Michigan United States 49120
    231 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    232 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    233 Henry Ford Medical Center-Columbus Novi Michigan United States 48377
    234 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    235 Hope Cancer Center Pontiac Michigan United States 48341
    236 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    237 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    238 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    239 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    240 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    241 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    242 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    243 Henry Ford Macomb Health Center - Shelby Township Shelby Michigan United States 48315
    244 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    245 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    246 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    247 Munson Medical Center Traverse City Michigan United States 49684
    248 GenesisCare USA - Troy Troy Michigan United States 48098
    249 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    250 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    251 Macomb Hematology Oncology PC Warren Michigan United States 48093
    252 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    253 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    254 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
    255 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    256 Henry Ford Wyandotte Hospital Wyandotte Michigan United States 48192
    257 Metro Health Hospital Wyoming Michigan United States 49519
    258 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    259 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    260 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    261 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    262 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    263 Cambridge Medical Center Cambridge Minnesota United States 55008
    264 Mercy Hospital Coon Rapids Minnesota United States 55433
    265 Fairview Southdale Hospital Edina Minnesota United States 55435
    266 Unity Hospital Fridley Minnesota United States 55432
    267 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    268 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    269 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    270 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    271 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    272 Health Partners Inc Minneapolis Minnesota United States 55454
    273 Monticello Cancer Center Monticello Minnesota United States 55362
    274 New Ulm Medical Center New Ulm Minnesota United States 56073
    275 Fairview Northland Medical Center Princeton Minnesota United States 55371
    276 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    277 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    278 Regions Hospital Saint Paul Minnesota United States 55101
    279 United Hospital Saint Paul Minnesota United States 55102
    280 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    281 Lakeview Hospital Stillwater Minnesota United States 55082
    282 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    283 Ridgeview Medical Center Waconia Minnesota United States 55387
    284 Rice Memorial Hospital Willmar Minnesota United States 56201
    285 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    286 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    287 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    288 Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi United States 39705
    289 Baptist Cancer Center-Grenada Grenada Mississippi United States 38901
    290 Jackson Oncology Associates PLLC Jackson Mississippi United States 39202
    291 University of Mississippi Medical Center Jackson Mississippi United States 39216
    292 Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi United States 38652
    293 Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi United States 38655
    294 Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi United States 38671
    295 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    296 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    297 Cox Cancer Center Branson Branson Missouri United States 65616
    298 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    299 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    300 Parkland Health Center - Farmington Farmington Missouri United States 63640
    301 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    302 Freeman Health System Joplin Missouri United States 64804
    303 Mercy Hospital Joplin Joplin Missouri United States 64804
    304 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    305 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    306 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    307 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    308 Mercy Hospital South Saint Louis Missouri United States 63128
    309 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    310 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    311 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    312 Mercy Hospital Springfield Springfield Missouri United States 65804
    313 CoxHealth South Hospital Springfield Missouri United States 65807
    314 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    315 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    316 Mercy Hospital Washington Washington Missouri United States 63090
    317 Community Hospital of Anaconda Anaconda Montana United States 59711
    318 Billings Clinic Cancer Center Billings Montana United States 59101
    319 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    320 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    321 Great Falls Clinic Great Falls Montana United States 59405
    322 Kalispell Regional Medical Center Kalispell Montana United States 59901
    323 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    324 Community Medical Hospital Missoula Montana United States 59804
    325 Nebraska Medicine-Bellevue Bellevue Nebraska United States 68123
    326 CHI Health Saint Francis Grand Island Nebraska United States 68803
    327 CHI Health Good Samaritan Kearney Nebraska United States 68847
    328 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    329 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    330 Oncology Associates PC Omaha Nebraska United States 68114
    331 Nebraska Medicine-Village Pointe Omaha Nebraska United States 68118
    332 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    333 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    334 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    335 Creighton University Medical Center Omaha Nebraska United States 68131
    336 University of Nebraska Medical Center Omaha Nebraska United States 68198
    337 Midlands Community Hospital Papillion Nebraska United States 68046
    338 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    339 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    340 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    341 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    342 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    343 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    344 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    345 GenesisCare USA - Henderson Henderson Nevada United States 89074
    346 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    347 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    348 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    349 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    350 Desert West Surgery Las Vegas Nevada United States 89102
    351 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    352 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    353 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    354 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    355 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    356 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    357 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    358 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    359 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    360 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    361 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    362 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    363 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    364 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    365 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    366 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    367 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    368 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    369 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    370 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    371 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    372 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    373 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    374 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    375 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    376 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    377 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    378 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    379 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    380 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    381 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    382 University Cancer Center Las Vegas Nevada United States 89169
    383 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    384 Renown Regional Medical Center Reno Nevada United States 89502
    385 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    386 Radiation Oncology Associates Reno Nevada United States 89509
    387 Inspira Medical Center Mullica Hill Mullica Hill New Jersey United States 08062
    388 Inspira Medical Center Vineland Vineland New Jersey United States 08360
    389 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    390 Mount Sinai Chelsea New York New York United States 10011
    391 Mount Sinai Hospital New York New York United States 10029
    392 Stony Brook University Medical Center Stony Brook New York United States 11794
    393 Atrium Health Stanly/LCI-Albemarle Albemarle North Carolina United States 28002
    394 Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina United States 28203
    395 Atrium Health Pineville/LCI-Pineville Charlotte North Carolina United States 28210
    396 Wake Forest University at Clemmons Clemmons North Carolina United States 27012
    397 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    398 Atrium Health Cabarrus/LCI-Concord Concord North Carolina United States 28025
    399 Levine Cancer Institute-Gaston Gastonia North Carolina United States 28054
    400 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    401 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    402 Atrium Health Lincoln/LCI-Lincolnton Lincolnton North Carolina United States 28092
    403 Atrium Health Union/LCI-Union Monroe North Carolina United States 28112
    404 FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina United States 28374
    405 Wake Forest University Health Sciences Winston-Salem North Carolina United States 27157
    406 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    407 Sanford South University Medical Center Fargo North Dakota United States 58103
    408 Southpointe-Sanford Medical Center Fargo Fargo North Dakota United States 58103
    409 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    410 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    411 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    412 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    413 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    414 Cleveland Clinic Mercy Hospital Canton Ohio United States 44708
    415 Mercy Hematology and Oncology Associates Inc Canton Ohio United States 44708
    416 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    417 Miami Valley Hospital South Centerville Ohio United States 45459
    418 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    419 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    420 Bethesda North Hospital Cincinnati Ohio United States 45242
    421 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    422 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    423 Miami Valley Hospital Dayton Ohio United States 45409
    424 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    425 Miami Valley Hospital North Dayton Ohio United States 45415
    426 Armes Family Cancer Center Findlay Ohio United States 45840
    427 Blanchard Valley Hospital Findlay Ohio United States 45840
    428 Orion Cancer Care Findlay Ohio United States 45840
    429 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    430 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    431 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    432 Wayne Hospital Greenville Ohio United States 45331
    433 Greater Dayton Cancer Center Kettering Ohio United States 45409
    434 First Dayton Cancer Care Kettering Ohio United States 45420
    435 Kettering Medical Center Kettering Ohio United States 45429
    436 Springfield Regional Cancer Center Springfield Ohio United States 45504
    437 Springfield Regional Medical Center Springfield Ohio United States 45505
    438 Trinity's Tony Teramana Cancer Center Steubenville Ohio United States 43952
    439 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    440 Upper Valley Medical Center Troy Ohio United States 45373
    441 Saint Joseph Warren Hospital Warren Ohio United States 44484
    442 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    443 Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma United States 73505
    444 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    445 Integris Southwest Medical Center Oklahoma City Oklahoma United States 73109
    446 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    447 Integris Cancer Institute of Oklahoma Oklahoma City Oklahoma United States 73142
    448 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    449 Saint Charles Health System Bend Oregon United States 97701
    450 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    451 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    452 Bay Area Hospital Coos Bay Oregon United States 97420
    453 Providence Newberg Medical Center Newberg Oregon United States 97132
    454 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    455 Providence Portland Medical Center Portland Oregon United States 97213
    456 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    457 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    458 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    459 UPMC Altoona Altoona Pennsylvania United States 16601
    460 UPMC-Heritage Valley Health System Beaver Beaver Pennsylvania United States 15009
    461 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    462 UPMC Camp Hill Camp Hill Pennsylvania United States 17011
    463 Carlisle Regional Cancer Center Carlisle Pennsylvania United States 17015
    464 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    465 Chambersburg Hospital Chambersburg Pennsylvania United States 17201
    466 WellSpan Medical Oncology and Hematology Chambersburg Pennsylvania United States 17201
    467 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    468 Ephrata Cancer Center Ephrata Pennsylvania United States 17522
    469 Ephrata Community Hospital Ephrata Pennsylvania United States 17522
    470 UPMC Hillman Cancer Center Erie Erie Pennsylvania United States 16505
    471 UPMC Cancer Center at UPMC Horizon Farrell Pennsylvania United States 16121
    472 Adams Cancer Center Gettysburg Pennsylvania United States 17325
    473 UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania United States 15601
    474 Oncology Hematology Associates Greenville Pennsylvania United States 16125
    475 Cherry Tree Cancer Center Hanover Pennsylvania United States 17331
    476 UPMC Pinnacle Harrisburg Harrisburg Pennsylvania United States 17101
    477 UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania United States 17109
    478 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    479 UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown Pennsylvania United States 15901
    480 Sechler Family Cancer Center Lebanon Pennsylvania United States 17042
    481 UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania United States 15132
    482 UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania United States 17050
    483 UPMC Hillman Cancer Center - Part of Frick Hospital Mount Pleasant Pennsylvania United States 15666
    484 Arnold Palmer Cancer Center Medical Oncology Norwin N. Huntingdon Pennsylvania United States 15642
    485 Oncology Hematology Association Pittsburgh Pennsylvania United States 15215
    486 UPMC-Saint Margaret Pittsburgh Pennsylvania United States 15215
    487 UPMC-Mercy Hospital Pittsburgh Pennsylvania United States 15219
    488 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    489 UPMC-Passavant Hospital Pittsburgh Pennsylvania United States 15237
    490 UPMC-Saint Clair Hospital Cancer Center Pittsburgh Pennsylvania United States 15243
    491 UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania United States 16346
    492 UPMC Cancer Center-Uniontown Uniontown Pennsylvania United States 15401
    493 UPMC Cancer Center-Washington Washington Pennsylvania United States 15301
    494 UPMC West Mifflin-Cancer Center Jefferson West Mifflin Pennsylvania United States 15122
    495 UPMC Susquehanna Williamsport Pennsylvania United States 17701
    496 Divine Providence Hospital Williamsport Pennsylvania United States 17754
    497 Cancer Care Associates of York York Pennsylvania United States 17403
    498 WellSpan Health-York Cancer Center York Pennsylvania United States 17403
    499 WellSpan Health-York Hospital York Pennsylvania United States 17403
    500 UPMC Memorial York Pennsylvania United States 17408
    501 Carolina Regional Cancer Center Myrtle Beach South Carolina United States 29577
    502 Levine Cancer Institute-Rock Hill Rock Hill South Carolina United States 29732
    503 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    504 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    505 Bristol Regional Medical Center Bristol Tennessee United States 37620
    506 Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee United States 38017
    507 Ballad Health Cancer Care - Kingsport Kingsport Tennessee United States 37660
    508 Wellmont Holston Valley Hospital and Medical Center Kingsport Tennessee United States 37660
    509 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    510 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    511 M D Anderson Cancer Center Houston Texas United States 77030
    512 Wellmont Medical Associates-Bristol Bristol Virginia United States 24201
    513 Sovah Health Martinsville Martinsville Virginia United States 24115
    514 Southwest VA Regional Cancer Center Norton Virginia United States 24273
    515 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    516 Overlake Medical Center Bellevue Washington United States 98004
    517 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    518 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    519 Harrison Medical Center Bremerton Washington United States 98310
    520 Highline Medical Center-Main Campus Burien Washington United States 98166
    521 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    522 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    523 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    524 Providence Regional Cancer Partnership Everett Washington United States 98201
    525 Saint Francis Hospital Federal Way Washington United States 98003
    526 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    527 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    528 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    529 Saint Clare Hospital Lakewood Washington United States 98499
    530 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    531 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    532 Valley Medical Center Renton Washington United States 98055
    533 Pacific Gynecology Specialists Seattle Washington United States 98104
    534 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    535 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    536 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    537 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    538 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    539 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    540 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    541 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    542 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    543 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    544 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    545 Langlade Hospital and Cancer Center Antigo Wisconsin United States 54409
    546 HSHS Sacred Heart Hospital Eau Claire Wisconsin United States 54701
    547 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    548 Bellin Memorial Hospital Green Bay Wisconsin United States 54301
    549 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    550 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    551 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    552 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    553 Aspirus Medford Hospital Medford Wisconsin United States 54451
    554 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    555 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    556 Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin United States 54154
    557 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    558 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    559 Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin United States 54235-1495
    560 Aspirus Regional Cancer Center Wausau Wisconsin United States 54401
    561 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    562 Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin United States 54494
    563 Billings Clinic-Cody Cody Wyoming United States 82414
    564 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Nagla Abdel Karim, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT04334941
    Other Study ID Numbers:
    • NCI-2020-02093
    • NCI-2020-02093
    • S1929
    • S1929
    • U10CA180888
    First Posted:
    Apr 6, 2020
    Last Update Posted:
    Aug 24, 2022
    Last Verified:
    Apr 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Small Cell Lung Carcinoma
    Carcinoma, Small Cell
    Atezolizumab
    Talazoparib
    Antibodies, Monoclonal

    Study Results

    No Results Posted as of Aug 24, 2022