Comparing Eye Pressure Using Maximal Tolerated Local Therapy or Systemic Acetazolamide
Study Details
Study Description
Brief Summary
Local therapy for glaucoma is known to induce a conjunctival inflammation. Because of this, trabeculectomy is more likely to fail. The investigators exchange the local therapy by systemic therapy using acetazolamide and measure the eye pressure using local therapy and systemic therapy using acetazolamide. The investigators suspect an elevated eye pressure using acetazolamide compared to local therapy. In summary acetazolamide could be a better choice in reference to conjunctival inflammation, but a worse choice in reference to controlling eye pressure.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patient with a trabeculectomy planed
|
Drug: Acetazolamide for glaucoma patients to lower eye pressure
Acetazolamide tablets 3 times daily for 3 to 4 weeks
|
Outcome Measures
Primary Outcome Measures
- Eye pressure [Once at the beginning of the study and once 3 to 4 weeks later]
The eye pressure is measured at the beginning of the study, when the patient is using the maximal tolerated local therapy and 3 to 4 weeks later, when using systemic acetazolamide treatment.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients with uncontrolled intraocular eye pressure
-
Patients with planed trabeculectomy in 3 to 4 weeks
Exclusion Criteria:
-
Patients not meeting the inclusion criteria
-
Patients with known intolerance to acetazolamide
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Cologne | Cologne | Germany | 50924 |
Sponsors and Collaborators
- University of Cologne
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AcetazolamideTrialCologne