Familial Hyperlipidemia Family Registry

Sponsor

Poudre Valley Health System (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05814419

Collaborator

(none)

104

Enrollment

22.8

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The aim of the study is to identify children and families that are at risk for cardiovascular disease because of a condition known as familial hyperlipidemia. This condition may increase the risk of cardiac events such as hardening of the arteries anywhere in the body which can result in heart attacks, strokes, and death over ten fold.

Children have already been assessed in the Healthy Hearts screening program and identified as having elevated cholesterol. A buccal smear will identify whether the familial hyperlipidemia condition exist in your child.

If the child's test shows that they have the specific gene for familial hyperlipidemia and shows a genetic tendency towards premature heart disease, we would encourage genetic testing for as many blood family members as possible.

The study plan is to determine whether the Healthy Hearts screening program is a more effective way of identifying students at risk since it is estimated that less than 10% of those individuals with the problem have been identified. If it is effective, then it will be incorporated as part of the standard screening process in the Healthy Hearts program.

Aim 1: Is a school screening program a more effective method to identifying those at risk for familial hyperlipidemia? Aim 2: What percent of children with elevated cholesterol ≥ 200 mg/dl have familial hyperlipidemia?

Condition or Disease	Intervention/Treatment	Phase
Familial Hyperlipidemia

Study Design

Study Type:

Observational [Patient Registry]

Anticipated Enrollment :

104 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Familial Hyperlipidemia Family Registry

Anticipated Study Start Date :

Jun 1, 2023

Anticipated Primary Completion Date :

Apr 26, 2025

Anticipated Study Completion Date :

Apr 26, 2025

Outcome Measures

Primary Outcome Measures

FH Determination for Family members of School children with elevated Cholesterol and docmented FH variant [Evaluation of family members over a defined 5 year period]
Genetic evaluation for FH variants in family member of children with elevate Cholesterol on baseline screening