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Family Study of Lymphoproliferative Disorders

Sponsor
Mayo Clinic (Other)
Overall Status
Recruiting
CT.gov ID
NCT00626496
Collaborator
National Cancer Institute (NCI) (NIH)
3,000
Enrollment
1
Location
309
Anticipated Duration (Months)
9.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Blood and lymph node cancers can begin in either the lymphatic tissues (as in the case of lymphoma) or in the bone marrow (as with leukemia and myeloma), and they all are involved with the uncontrolled growth of white blood cells. There are many subtypes of these cancers, e.g., chronic lymphocytic leukemia and non-Hodgkin lymphoma. Since there is evidence that these cancers cluster in families, this study aims to understand how genetics and environmental exposures contribute to the development of these cancers.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    3000 participants
    Observational Model:
    Family-Based
    Time Perspective:
    Prospective
    Official Title:
    Genetic Epidemiology of Lymphoproliferative Disorders
    Actual Study Start Date :
    Apr 1, 2004
    Anticipated Primary Completion Date :
    Dec 31, 2025
    Anticipated Study Completion Date :
    Dec 31, 2029

    Outcome Measures

    Primary Outcome Measures

    1. Risk of blood or lymphoma [Ongoing]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 100 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes

    At least 2 living, blood related relatives, affected with a lymphoproliferative disorder.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Mayo Clinic Rochester Minnesota United States 55905

    Sponsors and Collaborators

    • Mayo Clinic
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Susan Slager, Ph.D., Mayo Clinic

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    Susan Slager, Professor, Mayo Clinic
    ClinicalTrials.gov Identifier:
    NCT00626496
    Other Study ID Numbers:
    • 489-04
    • U01CA118444
    First Posted:
    Feb 29, 2008
    Last Update Posted:
    Sep 1, 2021
    Last Verified:
    Aug 1, 2021
    Additional relevant MeSH terms:
    Lymphoma
    Multiple Myeloma
    Lymphoma, Non-Hodgkin
    Lymphoma, B-Cell
    Leukemia, Lymphoid
    Leukemia, Lymphocytic, Chronic, B-Cell
    Lymphoproliferative Disorders
    Lymphocytosis

    Study Results

    No Results Posted as of Sep 1, 2021