Efficacy of Vitamin C Injection on Fatigue in Workers After Work
Study Details
Study Description
Brief Summary
Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2/Phase 3 |
Detailed Description
Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: 1 Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes. |
Dietary Supplement: Ascorbic acid (Vitamin C)
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
Other Names:
|
| Placebo Comparator: 2 Intravenous injections of 120ml of normal saline over 30 minutes. |
Dietary Supplement: Normal saline
Single intravenous injection of 120ml of normal saline over 30 minutes
|
Outcome Measures
Primary Outcome Measures
- Degree of fatigue at the point of time with visual analogue scale from 0 to 10 [Before intravenous vitamin C injection and right after completing injections, and one day later]
Secondary Outcome Measures
- Reactive oxygen species [Before intravenous vitamin C injections, right after completing injections, and one day later]
- Plasma vitamin C level [Before intravenous vitamin C injections and right after completing injections]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Company workers working at least 5 days a week from morning to evening
-
Volunteers who provided written informed consent
Exclusion Criteria:
-
Acute illness
-
Chronic disease such as diabetes, hypertension, liver disease, or renal disease
-
Previous history of renal stone or gout
-
Pregnant or lactating women
-
Hypersensitivity to vitamins or intravenous injections
-
History of vitamin supplements orally or parenterally within 2 days
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | DongGuk University International Hospital | Goyang-si | Gyeonggi-do | Korea, Republic of | 410-773 |
Sponsors and Collaborators
- DongGuk University
- Korean Association For Vitamin Research
Investigators
- Principal Investigator: Chang H Yeom, MD, PhD, KwanDong University Myungji Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
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- Bryer SC, Goldfarb AH. Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. Int J Sport Nutr Exerc Metab. 2006 Jun;16(3):270-80.
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- Powers SK, Hamilton K. Antioxidants and exercise. Clin Sports Med. 1999 Jul;18(3):525-36. Review.
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- Weijl NI, Elsendoorn TJ, Lentjes EG, Hopman GD, Wipkink-Bakker A, Zwinderman AH, Cleton FJ, Osanto S. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur J Cancer. 2004 Jul;40(11):1713-23.
- DUIH 2008-1-1