Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)

Sponsor

University Hospital, Tours (Other)

Overall Status

Recruiting

CT.gov ID

NCT02423499

Collaborator

(none)

Enrollment

Location

72.2

Anticipated Duration (Months)

1.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.

Condition or Disease	Intervention/Treatment	Phase
Autism Spectrum Disorder Bipolar Disorder

Study Design

Study Type:

Observational

Anticipated Enrollment :

90 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder

Actual Study Start Date :

May 19, 2015

Anticipated Primary Completion Date :

May 26, 2021

Anticipated Study Completion Date :

May 26, 2021

Arms and Interventions

Arm	Intervention/Treatment
Autism Spectrum Disorder Autism Spectrum Disorder adults without intellectual disability
Bipolar Disorder Bipolar Disorder adults during normothymic phase of illness
Healthy Volonteers Healthy adults

Outcome Measures

Primary Outcome Measures

Physiological emotional response during emotion elicitation in a laboratory session (Pupil size measured by eye tracking, heart rate, electrodermal response, breath rate) during emotion elicitation in a laboratory session [average 1 hour]

Secondary Outcome Measures

Subjective emotional response during emotion elicitation in a laboratory session [average 1 hour]
Facial emotional response during emotion elicitation in a laboratory session [average 1 hour]
Experience sampling method in real life during a week (emotions, activities, social context, burden) [within the first 7 days after inclusion]
Physiological emotional response in real life (heart rate, electrodermal response, breath rate, actimetry) [within the first 24h approx. after inclusion]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 50 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

For all participants:
Age between 18 and 50 years
Normal vision (or corrected)
Absence of neurological disorder (epilepsy , head trauma, ... )
Ability to understand information about the protocol
Informed and signed consent
normal mood (euthymia)
normal or high intelligence
Subjects with ASD:
Subjects with an autism spectrum disorder according to the DSM-5
The diagnosis is confirmed by diagnostic interviews: ADI- R (Autism Diagnostic Interview-Revised) and / or ADOS (Autism Diagnostic Observation Schedule ) .
Subjects with bipolar disorder:
Diagnosis of bipolar disorder according to DSM-IV-TR or DSM -5
The diagnosis is confirmed by the MINI 6.0 (The Mini-International Neuropsychiatric Interview) .
Healthy volunteers:
Inclusion after checking the national register of healthy volunteers
No history of disease of the central nervous system or psychiatric disorder
No family history of ASD or BD in the first degree
Lack of psychotropic medication or current cardiotropic
Lack of psychiatric disorder on Axis I MINI 6.0
AQ Score < 32

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	LEMAIRE	Tours		France	37044

Sponsors and Collaborators

University Hospital, Tours

Investigators

Principal Investigator: Frédérique BONNET- BRILHAULT, Pr, University Center of Child and Adolescent Psychiatry, University Hospital of Tours
Principal Investigator: Wissam EL-HAGE, Pr, University Psychiatric Clinic, University Hospital of Tours
Principal Investigator: Valérie GISSOT, MD-PHD, Clinical Investigation Center, INSERM 14 15, University Hospital of Tours
Study Director: Mathieu LEMAIRE, MD-PHD, University Center of Child and Adolescent Psychiatry, University Hospital of Tours