MuSIFe: Febrile Illness in Guinea
Study Details
Study Description
Brief Summary
To date, the underlying causes of community-acquired fever, particularly non-malarial fever, are insufficiently documented in Guinea. Moreover, diagnostic capacity is limited, leading to inadequate prescription of antibiotics and antimalarials, as well as substantial delay in outbreak recognition. Thus, the investigators undertook a prospective observational multi-centric cohort study of febrile patients presenting at the emergency and outpatient department of selected health centers, districts and regional hospitals in four ecologically distinct sentinel health districts in Guinea.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- Pattern of symptoms and laboratory results at presentation and during follow-up [Day 0 and day 21]
Proportion will be estimated
- Syndromic and/or etiologic diagnoses as established at day 21 [Day 0]
Proportion will be estimated
- Pattern and duration of antibiotic use (and other treatments) [Day 0]
Proportion and mean or median will be estimated
- Immediate or secondary hospital admissions and of secondary/unscheduled visits [Day 0 and day 21]
Proportion will be estimated
- Participants alive (with or without symptoms) or dead at day 21. [Day 21]
Survival or mortality rate will be estimated
Secondary Outcome Measures
- White blood cells and C-reactive protein levels at baseline and association with syndromic/etiologic diagnoses and with patient outcome at day 21 [Day 0]
Mean or median level will be estimated
- Association of seasonal, geographical, demographic, clinical and first-line laboratory variables (malaria RDT and smear, biochemistry) with presenting syndromes/main etiologies [Day 0]
OR or RR will be estimated as appropriate
- Confirmed arboviral pathogens and identification of epidemiological/clinical/laboratory predictors [Day 0]
Proportions will be estimated
- Cases fulfilling any of the case definitions of the 20 epidemic-prone infections under surveillance as compared to the final diagnosis and proportion of them timely reported to health authorities [Day 0]
Proportions will be estimated
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age ≥2 months old
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Documented fever (axillary temperature >37.5°C) at presentation or fever reported within the prior 24 hours
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Availability for follow-up for 21 days
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Willingness and ability of the patient or culturally acceptable representative to give informed consent for participation in the study
Exclusion Criteria:
- History of hospitalization (for > 48 hours within the last 14 days) at any health facility
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centre National de Formation et de Recherche en Santé Rurale | Maférinya | Forécariah | Guinea | 2649 |
Sponsors and Collaborators
- Centre National de Formation et de Recherche en Sante Rurale
- Institute of Tropical Medicine, Belgium
Investigators
- Study Director: Emmanuel Bottieau, MD, MSc, PhD, Institute of Tropical Medicine, Antwerp, Belgium
Study Documents (Full-Text)
None provided.More Information
Publications
- IRB/RR/AC/041_1616/22_ITM
- 139/CNERS/23
- IRB/RR/AC/041_1616/22