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Effect of Resistant Wheat Starch on Subjective Appetite and Food Intake in Healthy Adults

Sponsor
Iowa State University (Other)
Overall Status
Completed
CT.gov ID
NCT02689791
Collaborator
(none)
31
Enrollment
2
Arms
31
Duration (Months)

Study Details

Study Description

Brief Summary

A randomized, single-blind, cross-over study was conducted to determine the effect of replacing standard wheat flour (SWF) with resistant wheat starch (RWS) on markers of appetite and food intake in healthy adults.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Resistant Starch Type 4
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
31 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Single (Participant)
Official Title:
Effect of Resistant Wheat Starch on Subjective Appetite and Food Intake in Healthy Adults
Study Start Date :
Jan 1, 2012
Actual Primary Completion Date :
Jan 1, 2013
Actual Study Completion Date :
Aug 1, 2014

Arms and Interventions

Arm Intervention/Treatment
No Intervention: Control (SWF)

Standard Wheat Flour (SWF) Muffins
Experimental: Resistant Starch Type 4

Resistant Wheat Starch Muffins

Dietary Supplement: Resistant Starch Type 4
single dose 26g fiber given at the breakfast meal
Other Names:
  • Fibersym

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Caloric intake [Single Day]

      calories consumed at post-treatment lunch meal and total calories consumed on the treatment day

    Secondary Outcome Measures

    1. Visual analogue scale measures of subjective appetite [Single Day]

      0-100mm scale to assess hunger, fullness, thirst, desire to eat and prospective consumption

    2. Serum concentrations of biomarkers of appetite [150 minutes]

      CCK, ghrelin, PYY3-36 and GLP-1

    3. Plasma concentrations of biomarkers of glycemic response [150 minutes]

      Glucose, Insulin, GLP-1

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 35 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • BMI 18.5-29.9 kg/m2

    • Regular breakfast consumers (>5 days/week)

    Exclusion Criteria:

    • not weight stable (?3 kg weight change in previous 3 months)

    • use/used tobacco products

    • presence of acute or chronic illness

    • restrained eater (>13 on the restraint section of the three-factor eating questionnaire)

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Iowa State University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    James Hollis, Assistant Professor, Iowa State University
    ClinicalTrials.gov Identifier:
    NCT02689791
    Other Study ID Numbers:
    • IowaSU
    First Posted:
    Feb 24, 2016
    Last Update Posted:
    Feb 24, 2016
    Last Verified:
    Feb 1, 2016
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Keywords provided by James Hollis, Assistant Professor, Iowa State University
    Appetite
    Food Intake
    Satiety Hormones

    Study Results

    No Results Posted as of Feb 24, 2016