GREFFE: Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Sponsor

University of Burgundy (Other)

Overall Status

Recruiting

CT.gov ID

NCT02931812

Collaborator

(none)

Enrollment

Location

103

Duration (Months)

0.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients

Condition or Disease	Intervention/Treatment	Phase
Cirrhosis Food Preferences Taste Disorders Protein-Energy Malnutrition Chronic Renal Failure

Detailed Description

Background and Aims: Protein-energy malnutrition is associated to cirrhosis with a high prevalence and greatly increases the morbidity and mortality of the disease. Malnutrition results of numerous causes including intestinal malabsorption, increased energy resting expenditure, metabolism disturbances, impaired sensory taste and changes in food preferences which might participate to a reduction in food intake. The aim of this study was to determine the relationships that may exist between taste sensitivity and food preferences on the one hand, eating habits, nutritional status, energy balance and biological parameters including amino acids on the other hand in patients with end-stage cirrhosis and in patients with renal failure.

Fifteen end-stage cirrhotic patients and 15 renal failure patients will be included and matched with 30 healthy subjects. The following parameters will be evaluated during a morning testing session: gustatory sensitivity using a triangular detection threshold method for sweet, salty and umami solutions; preferences for fat- and carbohydrate-rich foods using the PrefQuest score; liking for six foods (protein-, carbohydrate- and fat-rich foods) and wanting for 18 foods (photographs); hunger sensation; energy intake (24 h ingested food); body composition (BMI and impedancemetry); resting energy expenditure (indirect calorimetry) and physical activity (questionnaire). Several plasmatic parameters (amino-acids, leptin, ghrelin, lipid profile) will be also determined.

Study Design

Study Type:

Observational

Anticipated Enrollment :

60 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Study Start Date :

May 1, 2014

Anticipated Primary Completion Date :

May 1, 2020

Anticipated Study Completion Date :

Dec 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Cirrhotic subjects 15 cirrhotic patients in end-stage in waiting a graft
Chronic kidney disease subjects 15 chronic kidney disease patients in end-stage in waiting a graft
Healthy subjects 30 healthy subjects to compare

Outcome Measures

Primary Outcome Measures

Energy expenditure [two years]
evice: indirect calorimetry (sensormedics)
body composition [2 years]
Device: Multifrequency bio-impedancemetry (aminostats)
amino acids profil in plasma [2 years]
Biological measurments
Food preferences [2 years]
Device: Treshold taste detection