Clinical Research for the Diagnosis of Tick-borne Diseases in Patients With Unexplained Acute Fever
Study Details
Study Description
Brief Summary
The study will use several laboratory diagnoses in the diagnosis of patients with fever，to find out which will be more helpful for making an accurate diagnosis in the early period of Tickborne Diseases.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Tickborne Diseases(TBDs) spread throughout many countries and regions. In recent years, the incidence has a tendency to rise continuously. The clinical symptoms and laboratory features of tick-borne diseases are always of no specific, and the diagnostic methods available, such as observing the pathogen after cultivation or by the method of Gimenez、serological tests for antibody always can't make a timely diagnosis, especially in the early period of the disease. The development of polymerase chain reaction(PCR) has been applied for pathogen detection, and showed high sensitivity and specificity,and may contribute to early diagnose，but no standardized method of PCR has been as yet proposed. This study mean to explore several laboratory diagnoses to find out which will be more helpful for making an accurate diagnosis in the early period of TBDs.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Fever，none definite diagnosis Those who have fever，but the doctor can not make definite diagnoses with the diagnostic methods available. |
Other: diagnostic methods
explore several laboratory diagnostic methods to find out which will be more helpful for making an accurate diagnosis in the early period of TBDs.
|
Outcome Measures
Primary Outcome Measures
- Evidence of immunoglobulin M and immunoglobulin G titres in acute and convalescent serum or a fragment of the specific gene from patients' whole blood [within the first 14 days in hospital]
Secondary Outcome Measures
- the sensitivity and specificity of the laboratory diagnostic methods Related to the reserach [up to three years]
compare the sensitivity and specificity of all the laboratory diagnostic methods, using statistical methods, to find out the most helpful one for making an accurate diagnosis in the early period of TBDs.
Eligibility Criteria
Criteria
Inclusion Criteria:
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patients have fever more than one week
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temperature is higher than 38℃ Celsius degree
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full of physical examination and laboratory examination have been carried out after one week，but still cannot make a definite diagnosis
Exclusion Criteria:
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fever for non-infectious diseases such as rheumatic autoimmune disease or with tumor
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we find that the patient selected does not meet the selection criteria within the observation period
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patients leave with automatic discharge
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Organization Name Beijing Friendship Hospital,Capital Medical University | Beijing | Beijing | China | 100050 |
Sponsors and Collaborators
- Beijing Friendship Hospital
- Beijing Chao Yang Hospital
Investigators
- Study Director: wenjie Qi, archiater, Beijing Friendship Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Z151100004015029