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Evaluation of FFR, WSS, and TPF Using CCTA

Sponsor
Seoul National University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT01857687
Collaborator
(none)
100
Enrollment
2
Locations
50
Patients Per Site

Study Details

Study Description

Brief Summary

To assess the feasibility of CT-derived computed fractional flow reserve (FFRCT), wall shear stress and total plaque force on coronary atherosclerotic plaque and to collect the preliminary data to apply those parameters for the prediction of clinical outcomes in patients with coronary artery stenosis.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Noninvasive Evaluation of Ischemia Causing Coronary Stenosis, Wall Shear Stress, and Total Plaque Force Using Coronary CT Angiography (CCTA) and Physics-based Analytic Model Derived From Conservation of Energy
    Study Start Date :
    May 1, 2013
    Anticipated Primary Completion Date :
    May 1, 2014

    Arms and Interventions

    Arm Intervention/Treatment
    patients with coronary artery stenosis

    Outcome Measures

    Primary Outcome Measures

    1. CT-derived computed fractional flow reserve [at time of evaulation]

    Secondary Outcome Measures

    1. wall shear stress [at time of evaulation]

    2. total plaque force [at time of evaulation]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Consecutive patients with available CCTA within 3 months of invasive angiography and invasive imaging methods (IVUS or OCT)
    Exclusion Criteria:
    • Poor CT images (unable to reconstruct 3 dimensional coronary artery model)

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Seoul National University hospital Seoul Korea, Republic of 110744
    2 Seoul National University Hospital Seoul Korea, Republic of

    Sponsors and Collaborators

    • Seoul National University Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    Bon-Kwon Koo, Associate Professor of Medicine / Cardiology, Seoul National University Hospital
    ClinicalTrials.gov Identifier:
    NCT01857687
    Other Study ID Numbers:
    • SNUH CT-FFR WSS TPF
    First Posted:
    May 20, 2013
    Last Update Posted:
    Nov 27, 2013
    Last Verified:
    Nov 1, 2013
    Additional relevant MeSH terms:
    Plaque, Atherosclerotic

    Study Results

    No Results Posted as of Nov 27, 2013