Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio in Juvenile Idiopathic Arthritis

Sponsor

Assiut University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT06024486

Collaborator

(none)

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)

Condition or Disease	Intervention/Treatment	Phase
Juvenile Idiopathic Arthritis	Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)

Detailed Description

The JADAS27 includes a selected count of the following joints: cervical spine, elbows, wrists, metacarpophalangeal joints (from first to third), proximal interphalangeal joints, hips, knees and ankles.

Study Design

Study Type:

Observational

Anticipated Enrollment :

50 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Correlation of Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio With Disease Activity in Juvenile Idiopathic Arthritis

Anticipated Study Start Date :

Sep 1, 2023

Anticipated Primary Completion Date :

Mar 1, 2024

Anticipated Study Completion Date :

May 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
JIA cases juvenile idiopathic arthritis cases	Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR) measurement of serum albumin, fibrinogen and CRP
CONTROL age and sex matched healthy controls	Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR) measurement of serum albumin, fibrinogen and CRP

Arm

Intervention/Treatment

JIA cases

juvenile idiopathic arthritis cases

Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)

measurement of serum albumin, fibrinogen and CRP

CONTROL

age and sex matched healthy controls

Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)

measurement of serum albumin, fibrinogen and CRP

Outcome Measures

Primary Outcome Measures

The fibrinogen to albumin ratio [3 months]
measurement of serum fibrinogen and albumin
The CRP to albumin ratio [3 MONTHS]
measurement of serum CRP and albumin
Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side [3 MONTHS]
correlation of these ratios with JADAS27

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A to 16 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects

Exclusion Criteria:

Other systemic inflammatory or autoimmune disorders.
History of corticosteroid medication in the last 6 months.
Liver diseases.
Malignancy.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Assiut University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Maha Sayed Ibrahim Abdelrahman, principal investigator, Assiut University

ClinicalTrials.gov Identifier:

NCT06024486

Other Study ID Numbers:

Juvenile arthritis assiut u

First Posted:

Sep 6, 2023

Last Update Posted:

Sep 6, 2023

Last Verified:

Aug 1, 2023

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Arthritis

Arthritis, Juvenile

Study Results

No Results Posted as of Sep 6, 2023