Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes
Sponsor
Harvard School of Public Health (HSPH) (Other)
Overall Status
Completed
CT.gov ID
NCT03348566
Collaborator
(none)
22,000
12.9
Study Details
Study Description
Brief Summary
the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Actual Enrollment
:
22000 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Change
Actual Study Start Date
:
Feb 1, 2015
Actual Primary Completion Date
:
Mar 1, 2016
Actual Study Completion Date
:
Mar 1, 2016
Outcome Measures
Primary Outcome Measures
- weight changes [6-10 years]
long term weight changes: this study measured body weight at baseline (1990) and follow up body weight in 2000. The long term body weight was defined as changes from baseline to follow up endpoint
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
11,323 women of European ancestry.
-
Informed consent was obtained from all participants. The DNA extraction methods, quality control measures,
-
SNPs genotyping and imputation data are available .
-
Both cases and controls with genotyping data are available based on GWASs
Exclusion Criteria:
- participants without genetic data
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Harvard School of Public Health (HSPH)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Heianza Y, Qi L. Gene-Diet Interaction and Precision Nutrition in Obesity. Int J Mol Sci. 2017 Apr 7;18(4). pii: E787. doi: 10.3390/ijms18040787. Review.
- Qi Q, Chu AY, Kang JH, Huang J, Rose LM, Jensen MK, Liang L, Curhan GC, Pasquale LR, Wiggs JL, De Vivo I, Chan AT, Choi HK, Tamimi RM, Ridker PM, Hunter DJ, Willett WC, Rimm EB, Chasman DI, Hu FB, Qi L. Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ. 2014 Mar 19;348:g1610. doi: 10.1136/bmj.g1610.
Responsible Party:
Tao Huang,
Assistant professor,
Harvard School of Public Health (HSPH)
ClinicalTrials.gov Identifier:
NCT03348566
Other Study ID Numbers:
- NHS25487541
First Posted:
Nov 21, 2017
Last Update Posted:
Jan 17, 2018
Last Verified:
Jan 1, 2018
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: