REACH-PD: Flexible Reaching Control in Parkinson Disease

Sponsor
Université Catholique de Louvain (Other)
Overall Status
Recruiting
CT.gov ID
NCT05908266
Collaborator
(none)
100
1
54
1.9

Study Details

Study Description

Brief Summary

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

Condition or Disease Intervention/Treatment Phase
  • Other: Reaching movements
  • Other: Disease Assessment

Study Design

Study Type:
Observational
Anticipated Enrollment :
100 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
Behavioural Study of Reaching Control in Healthy Volunteers and Volunteers With Parkinson Disease in Dynamical Context
Actual Study Start Date :
May 1, 2023
Anticipated Primary Completion Date :
Oct 31, 2027
Anticipated Study Completion Date :
Oct 31, 2027

Arms and Interventions

Arm Intervention/Treatment
PD

Patients with Parkinson disease

Other: Reaching movements
Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.

Other: Disease Assessment
Disease stage assessed by trained professionals

Control

Healthy volunteers

Other: Reaching movements
Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.

Outcome Measures

Primary Outcome Measures

  1. Kinematics [Measured during the entire experiment (an average of 4.5 years)]

    Position of the handle as a function of time. Units are millimetres

  2. Surface Electromyogram [Measured during the entire experiment (an average of 4.5 years)]

    Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts

  3. Applied forces [Measured during the entire experiment (an average of 4.5 years)]

    Forces applied by participants on the robotic handle. Units are Newtons

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 99 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Ability to perform the task (assessed during the experiment)
Exclusion Criteria:
  • Inability to perform the task (motor) or to understand the task requirements (cognitive)

Contacts and Locations

Locations

Site City State Country Postal Code
1 Université catholique de Louvain Louvain-la-Neuve Belgium 1348

Sponsors and Collaborators

  • Université Catholique de Louvain

Investigators

  • Study Director: Frédéric Crevecoeur, PhD, Université Catholique de Louvain

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Université Catholique de Louvain
ClinicalTrials.gov Identifier:
NCT05908266
Other Study ID Numbers:
  • REACH-PD
First Posted:
Jun 18, 2023
Last Update Posted:
Jun 18, 2023
Last Verified:
Jun 1, 2023
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jun 18, 2023