Blood Flow Restriction Training in Pre-frail and Frail Older Adults
Study Details
Study Description
Brief Summary
Frailty is most often defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes. Intervention such as exercise, especially resistance exercise, has proven to be effective to improve frail condition in the elderly in the previous literature. However, blood flow restriction (BFR) training, a new resistance exercise training method, need merely lower resistance power and shorter training duration compared with traditional resistance exercise. Previous researches also demonstrated BFR can increase muscle mass and muscle strength in the healthy elderly but the effect of BFR training on the pre-frail or frail elderly is unknown. The aim of this study will test the effect of BFR training on muscle strength and functional performance in pre-frail or frail elderly. Participants aged over 60 years old with clinical frailty score between 3 to 5 will be recruited. Participants will be assigned to two groups using randomized block design with BFR training and control group. Structured questionnaire and physical function measurement will be used to assess the pre-intervention condition and outcome of different interventions. The participants will be assessed before training (pre-test), 3 weeks after training, and 6 weeks after training (post-test), and followed up at one and three months after training. Physical function measurement will include hand grip, muscle mass over trunk and extremity, muscle strength of lower extremity, gait speed and timed up and go test. Two-way repeated measures analysis of variance will be used to test the pre-test, 3-week, post-test and follow-ups difference between the two groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Blood flow restriction resistance training
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Other: Blood flow restriction resistance training
The participants will carry weights and perform certain resistance exercises, such as step-up, sit-to-stand, and tip-toe-standing. The experimental group will execute the training with blood flow restriction.
|
| Active Comparator: Resistance training
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Other: Resistance training
The participants will carry weights and perform certain resistance exercises, such as step-up, sit-to-stand, and tip-toe-standing. The control group will execute the training without blood flow restriction.
|
Outcome Measures
Primary Outcome Measures
- Change of muscle strength of the lower extremities [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
Bilateral hip flexors, knee extensors, ankle dorsiflexors and ankle plantarflexors
- Change of 30 seconds sit to stand [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
30 seconds sit to stand
- Change of timed-up-and-go test [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
Timed-up-and-go test
Secondary Outcome Measures
- Change of one-repetition maximum [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
One-repetition maximum of step-ups
- Change of muscle mass [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
Muscle mass of the upper and lower extremities and trunk
- Change of hand grip [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
Bilateral hand grip strength
- Change of physical activity level [Before training, 3 and 6 weeks after training, and one and two months follow-ups]
The International Physical Activity Questionnaire (IPAQ)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Aged over 60 years old
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Fried frailty index fulfill 1-2 criteria
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Able to walk 6 meters independently
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Able to understand and follow ≥ 3 instructions
Exclusion Criteria:
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Severe hypertension (>180/110mmHg)
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Peripheral neuropathy
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History of deep-vein thrombosis (DVT)
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Cardiovascular diseases (i.e. Heart failure NYHA Classification III or IV, myocardial infarction, pulmonary hypertension, coronary artery stenosis)
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Neuromuscular diseases (i.e. Stroke, Parkinsons' disease)
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History of resisted exercise training program within the last 6 months before screening
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Cheng Kung University Hospital | Tainan city | Taiwan |
Sponsors and Collaborators
- National Cheng Kung University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- A-BR-108-111-T