Frequency and Origin of Dysnatremias in the Emergency Department

Sponsor

University Hospital Inselspital, Berne (Other)

Overall Status

Withdrawn

CT.gov ID

NCT01326429

Collaborator

Steering committee of the NCCR (Other)

Enrollment

Duration (Months)

Study Details

Study Description

Brief Summary

Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in the prevalence of the electrolyte disorders. Only little data is available on the frequency and the mechanisms leading to hypo-/hypernatremia.

Thus, the investigators aim to A.) determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital and B.) explore the mechanisms leading to the development of dysnatremias by detailed clinical and laboratory examinations.

Condition or Disease	Intervention/Treatment	Phase
Hyponatremia Hypernatremia

Study Design

Study Type:

Observational

Actual Enrollment :

0 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Frequency and Origin of Dysnatremias in the Emergency Department

Study Start Date :

Oct 1, 2011

Actual Primary Completion Date :

Mar 1, 2013

Actual Study Completion Date :

Mar 1, 2013

Arms and Interventions

Arm	Intervention/Treatment
Hypernatremia Patients admitted to the emergency department with a serum sodium exceeding 145 mmol/L.
Hyponatremia Patients admitted to the emergency room with a serum sodium below 135 mmol/L.

Outcome Measures

Primary Outcome Measures

Frequency of hypo- and hypernatremia in the emergency department [approx. 6 months]
The investigators aim to determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital.

Secondary Outcome Measures

Origin of hypo- and hypernatremia in the emergency department [approx. 6 months]
The investigators try to investigate the mechanisms leading to the development of hypo- and hypernatremia in patients admitted to the emergency department.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Serum sodium below 135 mmol/L (i.e. hyponatremia); serum sodium exceeding 145 mmol/L (hypernatremia)

Exclusion Criteria:

Patients below age 18 years; patients declining study participation.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

University Hospital Inselspital, Berne
Steering committee of the NCCR

Investigators

Principal Investigator: Gregor Lindner, M.D., Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
Study Chair: Felix J Frey, M.D., Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern