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FTO Gene Variants and Diet in Obesity

Sponsor
Hacettepe University (Other)
Overall Status
Completed
CT.gov ID
NCT04205318
Collaborator
University of Reading (Other), The Scientific and Technological Research Council of Turkey (Other)
400
Enrollment
1
Location
22
Actual Duration (Months)
18.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. The study included 200 obese and 200 non-obese individuals from Turkey. Our study suggests that the effect of the SNPs on obesity traits is likely to be influenced by lifestyle factors in this Turkish population.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    400 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    Impact of FTO Gene Variants and Lifestyle Factors on Obesity Traits in a Turkish Population
    Actual Study Start Date :
    Mar 1, 2017
    Actual Primary Completion Date :
    Feb 1, 2018
    Actual Study Completion Date :
    Dec 31, 2018

    Arms and Interventions

    Arm Intervention/Treatment
    study

    obese (BMI ≥25.00 kg/m2, n=200)
    control

    non-obese (BMI= 18.50-24.99 kg/m2, n=200)

    Outcome Measures

    Primary Outcome Measures

    1. Genetic analysis of two SNPs at FTO gene [up to 36 weeks]

      FTO SNPs rs9939609 and rs10163409

    2. Anthropometric measurements [up to 36 weeks]

      Body mass index, waist circumference, hip circumference, body composition

    3. Biochemical measurements [up to 36 weeks]

      lipid profile, glucose, insulin, adiponectin

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    24 Years to 50 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    1. attending routine outpatient visits,

    2. aged 24 to 50 years,

    3. having a BMI ≥ 18.50 kg/m2

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Zehra Buyuktuncer Ankara Turkey 06100

    Sponsors and Collaborators

    • Hacettepe University
    • University of Reading
    • The Scientific and Technological Research Council of Turkey

    Investigators

    • Principal Investigator: Zehra Buyuktuncer, Hacettepe University, Department of Nutrition and Dietetics, Ankara, TURKEY
    • Principal Investigator: Vimales Karani Santhanakrishnan, Department of Food and Nutritional Sciences, University of Reading, UK

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    ZEHRA BUYUKTUNCER, Professor, Hacettepe University
    ClinicalTrials.gov Identifier:
    NCT04205318
    Other Study ID Numbers:
    • GO15/612-11
    First Posted:
    Dec 19, 2019
    Last Update Posted:
    Dec 19, 2019
    Last Verified:
    Aug 1, 2019
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by ZEHRA BUYUKTUNCER, Professor, Hacettepe University
    obesity
    gene-diet interaction
    FTO gene variant
    Additional relevant MeSH terms:
    Obesity
    Disease Susceptibility
    Genetic Predisposition to Disease

    Study Results

    No Results Posted as of Dec 19, 2019